Abstract: Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as Alzheimer's disease. For example, compounds of Formula I, compositions containing the compounds, and methods for using the compounds and compositions are provided herein: wherein X is absent, CH2, or C(O); R1 is H, OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino; R2 is H or C1-6 alkyl; R3 is H, C1-6 alkyl, —C(O)(C1-3 alkyl), or —C(O)O(C1-3 alkyl); R4 is C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, or 5-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 independently selected R5 groups; and R5 is OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino.

Abstract: A powder bed containment system for use with a rotating direct metal laser melting (DMLM) system includes an annular build plate, which includes an inner wall, an outer wall concentric with the inner wall and spaced radially apart from the inner wall, and a substantially planar build surface extending between the inner wall and the outer wall, where the substantially planar build surface is arranged to receive a weldable powder for manufacture of an object.

Abstract: Described herein are systems, devices, methods, and media for emergency spatiotemporal analysis. One or more emergency response resources may be returned, transmitted and displayed. In some embodiments, emergency metrics may be determined and displayed.

Abstract: An animal decoy device is presented. The animal decoy device comprises a panel or panels with a realistic representation of a turkey tail fan imprinted thereon and a plurality of pockets located on a central area substantially on a lower portion of the decoy, wherein each pocket is configured to retain a quill of a feather.

Abstract: In an embodiment, a headset display device includes a central processor and multiple projector integrated circuits each coupled to the central processor and configured to process image data. Each projector integrated circuit includes multiple first integrated circuits, each including a light emitter array. Each projector integrated circuit includes a second integrated circuit coupled to the multiple first integrated circuits. The second integrated circuit includes a graphics processor configured to generate transformed image data correcting for geometrical or brightness distortions and (2) is configured to provide the transformed image data to the multiple first integrated circuits for display.

Abstract: Methods, apparatuses, and systems for making prepregs are disclosed. A method may include depositing a resin material onto a surface of a fiber bed and forming a number of discrete resin regions thereon. A distance between the resin regions may be measured to provide desired exposed portions of the surface to facilitate permeation of air through the exposed portions of the surface in a direction perpendicular to a plane of the fiber bed during a curing process of the prepreg.

Abstract: A device for dispensing consumables includes a housing, a drawer, a cap, a latch, and a tooth. The housing may define a volume. The drawer defines a cavity and may be disposed in the volume. The cap may be along the housing. The latch may be securable to hold the cap in a closed position enclosing the volume. In response to a force exceeding a threshold force on the latch, the cap may be movable from the closed position to an open position exposing the volume. The tooth may be mechanically coupled to the latch and, in response to the force exceeding the threshold force on the latch, the tooth may movable in the cavity in a direction directing a consumable unit out of the volume with the cap in the open position.

Abstract: A radiation shield assembly is described, configured to block radiation emanating from a radiation source from reaching a user. Two shields are supported by a support arm, and are configured to rotate and translate relative to one another about the support arm's longitudinal axis. This allows the shield to be easily configured and reconfigured as necessary to visualize various parts of a patients body via radiography.

Abstract: The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties.

Abstract: In some aspects, a method of authoring an interactive presentation includes defining a sequence of two or more primary content items within a presentation, and associating a link to additional content with a primary content item of the sequence in a non-transitory computer-readable medium. In additional aspects, a method of delivering an interactive presentation includes accessing the sequence of two or more primary content items, delivering the primary content items to a presentation device, and delivering, to applications operating on mobile devices of audience members, the primary content items with the additional content and/or one or more links thereto. In further aspects, a method of interacting with an interactive presentation includes receiving, by a mobile device of an audience member, a sequence of primary content items with additional content and/or one or more links thereto, and displaying the received primary content items and the additional content.

Abstract: A system can include a tractor bucket adapter configured to be removably attached to a bucket of a tractor, and a component configured to be removably attached to the tractor bucket adapter. The component may be a digging tool or a sod removal tool. The system can also include an intermediary component to facilitate removable attachment between the tractor bucket adapter and the component.

Abstract: A portable exercise apparatus in the shape of a square having a handle at either side, which handles are arranged rotatable on spindles such that the user can impart movement on said apparatus without changing his/her grip.

Abstract: Described herein are systems, devices, methods, and media for connecting a user for providing emergency assistance based on emergency alerts from triggering devices such as voice or sound triggered emergency alerts. In some cases, the location of the emergency is provided.

Abstract: A composition comprising at least one AAV vector formulated for intrathecal delivery to the central nervous system is described. The composition comprises at least one expression cassette which contains sequences encoding an immunoglobulin construct linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn).

Abstract: A method of forming a build in a powder bed includes providing a first diode laser fiber array and a second diode laser fiber array, emitting a plurality of laser beams from selected fibers of the second diode laser fiber array onto the powder bed, corresponding to a pattern of a layer of the build, simultaneously melting powder in the powder bed corresponding to the pattern of the layer of the build, scanning a first diode laser fiber array along an outer boundary of the powder bed and emitting a plurality of laser beams from selected fibers of the first diode laser fiber array and simultaneously melting powder in the powder bed corresponding to the outer boundary of the layer of the build to contour the layer of the build. An apparatus for forming a build in a powder bed including a first diode laser fiber array and a second diode laser fiber array is also disclosed. The first diode laser fiber array configured to contour the layer of the build.

Abstract: A “Concurrent Projector-Camera” uses an image projection device in combination with one or more cameras to enable various techniques that provide visually flicker-free projection of images or video, while real-time image or video capture is occurring in that same space. The Concurrent Projector-Camera provides this projection in a manner that eliminates video feedback into the real-time image or video capture. More specifically, the Concurrent Projector-Camera dynamically synchronizes a combination of projector lighting (or light-control points) on-state temporal compression in combination with on-state temporal shifting during each image frame projection to open a “capture time slot” for image capture during which no image is being projected. This capture time slot represents a tradeoff between image capture time and decreased brightness of the projected image.

Abstract: One example disclosed method involves a computing system determining that a first shared computing resource, included among a plurality of shared computing resources managed by a controller, is potentially faulty. The system may configure the controller to identify the first shared computing resource with a tag, the tag configured to cause the controller, in response to a client requesting the controller for access to a first application, to assign the first shared computing resource to deliver the first application to the client. The system may instruct the client to request the controller for access to the first application. The system may determine that the first shared computing resource is faulty based on the client being unable to access the first application at a time of application of the tag to the first shared computing resource. The system may take a corrective action with respect to the first shared computing resource.

Abstract: A cavity mold comprises two or more sub-molds; and one or more gasket disposed between two adjacent sub-molds; wherein the gasket seals heating and cooling mediums when the cavity mold is assembled; wherein each of the two or more sub-molds comprises an outer casing; an inner casing on which a molded item is formed, wherein the cavity mold is assembled, a cavity is formed in the space between the outer casing and the inner casing; at least one heating/cooling mediums input pipe that is fluidly coupled with heating and cooling medium sources and the cavity, wherein heating and cooling mediums are pumped or compressed via the at least one heating/cooling mediums input pipe into the cavity, thereby the heating and cooling mediums pass through the cavity of the cavity mold; and at least one heating/cooling mediums return pipe that is fluidly coupled with the heating and cooling medium sources and the cavity, wherein the heating and cooling mediums are pumped via the at least one heating/cooling mediums return pip

Abstract: Methods of manufacturing or repairing a turbine blade or vane are described. The airfoil portions of these turbine components are typically manufactured by casting in a ceramic mold, and a surface made up of the cast airfoil and at the least the ceramic core serves as a build surface for a subsequent process of additively manufacturing the tip portions. The build surface is created by removing a top portion of the airfoil and the core, or by placing an ultra-thin shim on top of the airfoil and the core. The overhang projected by the shim is subsequently removed. These methods are not limited to turbine engine applications, but can be applied to any metallic object that can benefit from casting and additive manufacturing processes. The present disclosure also relates to finished and intermediate products prepared by these methods.