Abstract: The present invention relates to synergistic combinations of the compound 5,6 -dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites and topoisomerase II inhibitors, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from carboplatin, gemcitabine, cisplatin, 5-fluorouracil, cyclophosphamide, etoposide, vincristine, doxorubicin and irinotecan. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing such combinations. The invention further provides for methods of preparing the combinations of the invention.

Abstract: This invention provides compounds defined by Formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of treating osteo- and rheumatoid arthritis.

Abstract: The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.

Abstract: Recovery apparatus for recovering radio frequency tags from solid support devices in the form of cans (2) which include such tags and also resin on which chemical compounds are synthesized includes a stack of cans (2) which are fed into the apparatus wherein they are received within a port (28) of a rotating disc (26). The disc rotates to a position adjacent to a magnet 32 and blade (34). In this position, the magnet attracts the radio frequency device so that it is raised upwardly towards the lid end of the can, whereafter the blade (34) is able to slice through the lower end of the can to open it, whereupon the solid support resin falls out of the can into a receptacle (36). The disc continues to move until the remains of the can are over a receptacle (40), whereupon the magnetic force is released so the tag falls into receptacle (40) from which it may be retrieved, for re-use.

Abstract: In order to reduce the area of a charge pump PLL, one may separate proportional component and integral component of the loop filter voltage, and add additional circuitry so as to make the integral component appear as though it is affected by a much larger value of capacitance than is actually used. In an aspect, a current mirror may be used to subtract a portion of the integral component of the loop filter voltage from the total loop filter voltage. The difference signal is then used to drive an oscillator in the charge pump PLL. In another aspect, a third integrator or auto-calibration loop is used to set a center frequency of the oscillator.

Abstract: A semiconductor laser device, with a semiconductor laser element operable to oscillate and output a laser beam, is provided with a heat generation unit operable to generate heat so as to regulate the temperature of the semiconductor laser element, a laser beam splitting unit operable to split a laser beam, oscillated and output from the semiconductor laser element, into first and second beams each forming an optical path different from each other, and a heat generation control unit operable to control the amount of heat generated by the heat generation unit so as to maintain constant a fringe spacing between interference fringes with a plurality of fringes obtained as a result of the interference between the first and second beams.

Abstract: A suspension system for supporting fore-and aft extending frame members of a vehicle chassis on a hollow axle, the system on one side of the vehicle being duplicated on the opposite side. Included in the suspension on each side are: (1) a frame bracket for pivotally supporting the fore or leading end of an asymmetric leaf spring; (2) a spring end support mounted on the frame side member for supporting the aft or trailing end of the leaf spring, and (3) a suitable assembly for attaching the leaf spring at a location intermediate its opposite ends to the axle so that the spring is divided into two cantilever limbs extending in opposite directions from the center line of the axle. The spring is formed so that one of the cantilever limbs has a stiffness substantially greater than the stiffness of the other limb. In all forms, at least one leaf of the asymmetric spring extends the full length of the spring.

Abstract: A vehicle leaf spring suspension having a low spring rate is disclosed. The suspension has an axle seat secured to a vehicle axle. The leaf spring is clamped at its spring seat area to the axle seat at the clamp group mounting surface of the axle seat and with certain of the disclosed axle seats, can be clamped such that the spring seat area is asymmetrically positioned with respect to the vehicle axle centerline. Also, an active clamp group arrangement can be used to utilize the entire physical length of the leaf spring.

Abstract: Apparatus and method for making circuitized substrates using a continuous roll format in which layers of conductor and dielectric are fed into the apparatus, bonded, and passed on to other nearby work stations in which various processes such as hole formation, circuitization and, finally, segmentation occur. The resulting substrates can then be individually bonded to other, like substrates to form a larger multi-layered substrate with a plurality of conductive thru-holes, conductive and dielectric layers as part thereof.

Abstract: A stacking support for at least one row of wine bottles is of sheet-like form with indentations (10) shaped to receive and locate at least one row of bottles in parallel relationship in a first layer. The indentations (10) are so arranged that when a second like support for carrying a second layer will be laterally offset with respect to those of the first layer so that the bottles of the second layer will be supported by the bottles of the first layer. The support is so configured that when it is used in conjunction with the second like support (16) the two supports (16) cooperate to ensure anti-sagging support in the zone of the endmost bottle-carrying indentation (10e) of the second layer only partially supported by the first layer.

Abstract: The present invention relates to a system, as well as articles and holographic recording medium comprising the system, where the system comprises: a polymerizable component comprising at least one photoactive polymerizable material; and a photoinitiator component comprising at least one photoinitiator for causing the polymerizable component to polymerize to thereby form a plurality of holographic gratings when activated by exposure to a photoinitiating light source; wherein when a portion of the polymerizable component has been polymerized to form at least one holographic grating, the unpolymerized portion of the polymerizable component is resistant to further polymerization when not exposed to the photoinitiating light source. The present invention also provides methods for forming at least one holographic grating in a holographic recording medium having such a photopolymerizable system.

Abstract: A comparator circuit includes a reference generator connecting to a first source providing a first voltage. The reference generator is operative to generate a reference signal and includes a control circuit selectively operable in at least a first mode or a second mode in response to a first control signal, wherein in the first mode the reference signal is not generated, and in the second mode the reference generator is operative to generate the reference signal. The comparator circuit further includes a comparator connecting to a second source providing a second voltage, the second voltage being less than the first voltage. The comparator is operative to receive the reference signal and an input signal, and to generate an output signal which is a function of a comparison between the input signal and the reference signal.

Abstract: This invention concerns the production of so called “hand tufted rugs”, carpets and wall hangings by use a “tufting machine” which employs a single hollow needle through which yarn is fed into a backing fabric, to form tufts of yarn. The machine comprises a yarn cutter, in the tufting head, which is selectively operable to cause the tufts to be cut or loop pile. A computer operated motion control system is operable under the control of a machine readable tufting design pattern comprising a series of vectors and associated control codes, to drive the tufting gun as follows: (a) to operate the mechanism and reciprocate the needle to insert tufts into backing fabric. (b) to operate the movement system and move the needle across a two-dimensional plane while inserting tufts, in accordance with the vectors. (c) to lift and lower the foot, in accordance with respective control codes. And, (d) to selectively operate the yarn cutter, in accordance with respective control codes.

Abstract: A method of facilitating biomolecular interaction measurements includes attaching an interaction species fluidic router to a substrate. A set of interaction species samples is routed through the interaction species fluidic router to produce a coated sensor surface with multiple reaction zones corresponding to the interaction species samples. The interaction species fluidic router is then removed from the substrate. A multi-sample fluidic router is then connected to the substrate. A set of fluidic samples is then directed through the multi-sample fluidic router to the multiple reaction zones. Optical signals corresponding to the resultant biomolecular interactions are then collected. The optical signals are subsequently processed to characterize the biomolecular interactions.

Abstract: Nanochannel electrophoretic and electrochemical devices having selectively-etched nanolaminates located in the fluid transport channel. The normally flat surfaces of the nanolaminate having exposed conductive (metal) stripes are selectively-etched to form trenches and baffles. The modifications of the prior utilized flat exposed surfaces increase the amount of exposed metal to facilitate electrochemical redox reaction or control the exposure of the metal surfaces to analytes of large size. These etched areas variously increase the sensitivity of electrochemical detection devices to low concentrations of analyte, improve the plug flow characteristic of the channel, and allow additional discrimination of the colloidal particles during cyclic voltammetry.

Abstract: Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydroxy, C1–C6 alkyl, C1–C6 alkoxy, C2–C6 alkenyl, C2–C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; R4 and R5 independently are H, C1–C6 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring containing carbon atoms and optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is an integer of from 0 to 6.

Abstract: An information processing system comprises a legacy application, a web services consumption copybook, and a set of application program interfaces for enabling the legacy application to access a selected web service via a web services consumption server. The web services consumption copybook represents data structures of the selected web service. The system can either connect to or include a set of web service proxies that each correspond to a web service available via a network connection. A web services consumption server is optionally used to route service requests from the application to the appropriate web service proxy. The system can also optionally include a developer tool for adapting legacy systems or environments to be able to consume web services using modern protocols thus allowing the migration of legacy subsystems to a networked loosely-coupled environment.

Abstract: Trailer tongue scale including a frame having at least one angularly disposed strut; a sleeve connected to and supported by the angularly disposed strut; and a force sensitive device connected to the frame such that the frame supports the force sensitive device; and a force indication device operable with the force sensitive device to reflect an amount of a force imposed upon the force sensitive device, the reflected amount being indicative of a force measurement; and a force transmission rod assembly disposed to move within the sleeve and disposed in operative communication with the force sensitive device and disposed to be operatively connected to a trailer tongue and thereby receive a force therefrom and transmit that force to the force sensitive device which provides for the force indication device to reflect the amount of that force. The scales may alternatively be disposed to provide an adjustable height.

Abstract: A method of forming a printed circuit card with a metal power plane layer between two photoimageable dielectric layers is provided. Photoformed metal filled vias and plated through holes are in the photopatternable material, and signal circuitry is on the surfaces of each of the dielectric materials connected to the vias and plated through holes. A border may be around the card including a metal layer terminating in from the edge of one of the dielectric layers. Copper foil with clearance holes is provided. First and second layers of photoimageable curable dielectric material are on opposite sides of the copper. Patterns are developed on the first and second layers of the photoimageable material to reveal the metal layer through vias. Through holes are developed where holes were patterned in both dielectric layers. The surfaces of the photoimageable material, vias and through holes are metallized by copper plating, preferably using photoresist.

Abstract: A novel inbred maize line designated PHB1V and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHB1V with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PHB1V through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the inbred line PHB1V or an introgressed trait conversion of PHB1V with another maize line. Inbred maize lines derived from inbred maize line PHB1V, methods for producing other inbred maize lines derived from inbred maize line PHB1V and the inbred maize lines and their parts derived by the use of those methods.