Abstract: The present invention is directed to dosing, dosage regimens, formulations, unit dosage forms, and related, of a PARP7 inhibitor for the treatment of cancer. The present invention is also directed to methods of treating cancer by administering the PARP7 inhibitor in combination with an antibody that binds to PD-1.

Abstract: The present disclosure describes a system (e.g., a self-checkout system) that includes a modifiable cabinet. The self-checkout system includes a cabinet, a scanner, a sleeve, and a panel. The cabinet includes a front side and a back side opposite the front side. The scanner is positioned on the cabinet. The scanner scans an item during checkout. The sleeve is positioned within the cabinet. The sleeve moves away from the front side of the cabinet and out the back side of the cabinet. The sleeve defines a chamber. The panel is positioned within the chamber. When the sleeve is moved away from the front side of the cabinet and out the back side of the cabinet, the panel folds down to create a shelf within the chamber.

Abstract: A substrate for a display article includes (a) a primary surface; and (b) a textured region on at least a portion of the primary surface, the textured region comprising: (i) one or more higher surfaces residing at a higher mean elevation parallel to a base-plane disposed below the textured region and extending through the substrate; (ii) one or more lower surfaces residing at a lower mean elevation parallel to the base-plane that is less than the higher mean elevation; and (iii) a high-index material disposed on each of the one or more lower surfaces residing at the lower mean elevation, the high-index material forming one or more intermediate surfaces residing at an intermediate mean elevation parallel to the base-plane that is greater than the lower mean elevation but less than the higher mean elevation.

Abstract: A method is performed at a server system associated with a media streaming service. The method includes providing, a first client device, playback of a first media content item; and receiving, from the first client device, a second media content item to be associated with the first media content item. The method includes, after receiving the second media content item from the first client device: providing, a second client device, a user interface that includes graphical representations of a plurality of media content items that have been uploaded by other users of the media streaming service as related to the first media content item; receiving, from the second client device, a user selection of a graphical representation of the second media content item; and in response, providing the second media content item concurrently with playback of the first media content item.

Abstract: The techniques described herein disclose a system that is configured to detect and track the three-dimensional pose of an object (e.g., a head-mounted display device) in a color image using an accessible three-dimensional model of the object. The system uses the three-dimensional pose of the object to repair pixel depth values associated with a region (e.g., a surface) of the object that is composed of material that absorbs light emitted by a time-of-flight depth sensor to determine depth. Consequently, a color-depth image (e.g., a Red-Green-Blue-Depth image or RGB-D image) can be produced that does not include dark holes on and around the region of the object that is composed of material that absorbs light emitted by the time-of-flight depth sensor.

Abstract: Techniques for steering overlay network traffic along specific paths through an underlay network. The techniques may include determining a path through an underlay network that is optimized for sending a packet from a first node of an overlay network to a second node of the overlay network. The techniques may also include determining a destination address for sending the packet along the path from the first node to the second node, the destination address including a micro segment identifier (uSID) corresponding with an underlay node that is disposed along the path through the underlay network and trailing bits representing a portion of an address that corresponds with the second node. The techniques may also include causing the packet to be modified to include the destination address such that the packet is sent from the first node to the second node along the path.

Abstract: Techniques for obtaining application network metadata from a service registry so that a network routing policy may be derived for traffic associated with the application are described herein. The techniques may include receiving, at a service registry, network metadata associated with traffic of an application hosted by a scalable application service platform. The techniques may also include obtaining, by a controller of a network and from the service registry, the network metadata associated with the traffic of the application. Based at least in part on the network metadata, the controller may determine a routing policy that is optimized for sending the traffic through the network. Additionally, the controller may send an indication of the routing policy to a node of the network or otherwise provision the network such that the traffic of the application is sent through the network according to the routing policy.

Abstract: Providing a foot orthotic (10) to a person including presenting a map of a foot and leg divided into predetermined regions to the person, receiving a selection from the person of one or more regions from the map corresponding to one or more locations where the person is experiencing pain or discomfort: defining a plurality of foot orthotic types. each foot orthotic type adapted to address pain or discomfort in the one or more regions where the person is experiencing pain or discomfort. and dispensing an orthotic (10) from the plurality of orthotic types such that the defined orthotic (10) is adapted to address pain or discomfort in the region where the person first experienced the pain or discomfort.

Abstract: A dual-chamber electrolysis vessel safely stores HHO gas for use by an internal combustion engine.

Abstract: Computing an image depicting a face having an expression with wrinkles is described. A 3D polygon mesh model of a face has a non-neutral expression. A tension map is computed from the 3D polygon mesh model. A neutral texture, a compressed wrinkle texture and an expanded wrinkle texture are computed or obtained from a library. The neutral texture comprises a map of the first face with a neutral expression. The compressed wrinkle texture is a map of the first face formed by aggregating maps of the first face with different expressions using the tension map, and the expanded wrinkle texture comprises a map of the first face formed by aggregating maps of the first face with different expressions using the tension map. A graphics engine may be used to apply the wrinkle textures to the 3D model according to the tension map; and render the image from the 3D model.

Abstract: Techniques for steering overlay network traffic along specific paths through an underlay network. The techniques may include determining a path through an underlay network that is optimized for sending a packet from a first node of an overlay network to a second node of the overlay network. The techniques may also include determining a destination address for sending the packet along the path from the first node to the second node, the destination address including a micro segment identifier (uSID) corresponding with an underlay node that is disposed along the path through the underlay network and trailing bits representing a portion of an address that corresponds with the second node. The techniques may also include causing the packet to be modified to include the destination address such that the packet is sent from the first node to the second node along the path.

Abstract: A multi-chamber assembly safely stores enhancement gas for efficient and complete combustion of a carbonaceous fuel is presented. The multi-chamber assembly safely stores the enhancement gas, for example, for use by the internal combustion engine such as an internal combustion engine of a vehicle and/or a generator.

Abstract: A system for efficient combustion of a carbonaceous fuel is presented. An ultra low quantity of enhancement gas may be introduced to an internal combustion engine to improve at least one operating metric of the internal combustion engine such as fuel economy and/or reduce engine-out emissions, for example in a vehicle or generator.

Abstract: Techniques for obtaining application network metadata from a service registry so that a network routing policy may be derived for traffic associated with the application are described herein. The techniques may include receiving, at a service registry, network metadata associated with traffic of an application hosted by a scalable application service platform. The techniques may also include obtaining, by a controller of a network and from the service registry, the network metadata associated with the traffic of the application. Based at least in part on the network metadata, the controller may determine a routing policy that is optimized for sending the traffic through the network. Additionally, the controller may send an indication of the routing policy to a node of the network or otherwise provision the network such that the traffic of the application is sent through the network according to the routing policy.

Abstract: Computing an image depicting a face having an expression with wrinkles is described. A 3D polygon mesh model of a face has a non-neutral expression. A tension map is computed from the 3D polygon mesh model. A neutral texture, a compressed wrinkle texture and an expanded wrinkle texture are computed or obtained from a library. The neutral texture comprises a map of the first face with a neutral expression. The compressed wrinkle texture is a map of the first face formed by aggregating maps of the first face with different expressions using the tension map, and the expanded wrinkle texture comprises a map of the first face formed by aggregating maps of the first face with different expressions using the tension map. A graphics engine may be used to apply the wrinkle textures to the 3D model according to the tension map; and render the image from the 3D model.

Abstract: A choke valve including a valve body defining an inlet defining a centrally disposed axis extending through the inlet, an outlet, and a chamber in fluidic communication with the inlet and the outlet, and a flow trim disposed within the chamber and having a side wall that defines a generally cylindrical shape, the flow trim defining a passage through the flow trim, a pair of diametrically opposing windows extending through the side wall, each window permitting fluid communication between the chamber and the passage in a direction orthogonal to the centrally disposed axis defined by the inlet, and a slot extending through the side wall, the slot being disposed substantially equidistantly between the pair of diametrically opposing windows orthogonal to the centrally disposed axis defined by the inlet and on a side of the flow trim opposite the inlet, the slot permitting containment of turbulence created by interaction of fluid flow through the windows.

Abstract: Techniques for dynamic routing based on application load are described herein. The techniques may include receiving load information associated with resources of an application orchestration system that are allocated to host an application, the resources associated with different geographical regions. Based at least in part on the load information, a network controller may determine that first resources of the application orchestration system are less constrained than second resources of the application orchestration system, the first resources associated with a first geographical region and the second resources associated with a second geographical region. Based at least in part on the first resources being less constrained than the second resources, application traffic may be routed through the network to the application hosted by the first resources in the first geographical region.

Abstract: Present disclosure describes techniques for determining document bias in a document set. The techniques include the step of receiving a document set comprising a plurality of documents, applying a Natural Language Processing (NLP) technique to the document set to identify one or more prevalent concepts in each document of the plurality of documents, and categorizing one or more concepts as a high prevalence concept and a low prevalence concept based on one or more parameters. The techniques further include the step of identifying one or more low prevalence concepts with negative sentiment and comparing the identified concepts with a plurality of keyword to determine at least one bias document/concept in the document set.

Abstract: Techniques for dynamic routing based on application load are described herein. The techniques may include receiving load information associated with resources of an application orchestration system that are allocated to host an application, the resources associated with different geographical regions. Based at least in part on the load information, a network controller may determine that first resources of the application orchestration system are less constrained than second resources of the application orchestration system, the first resources associated with a first geographical region and the second resources associated with a second geographical region. Based at least in part on the first resources being less constrained than the second resources, application traffic may be routed through the network to the application hosted by the first resources in the first geographical region.