Abstract: The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.

Abstract: Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of Notch3.

Abstract: Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.

Abstract: An application-operating organization may delegate a third-party server to serve as an automated contextual authentication responder and an authorization responder. The third-party server may manage a delegated section of the organization's namespace that includes the public identities of various devices controlled by the organization. The third-party server may also dynamically generate interaction control list that is tailored to a requesting device's context based on the interaction control policies set forth by the organization. The interaction control list may include information that determines the authorization of the requesting device to interact with another device. The third-party server may also automatically determine the role of a new device to which existing policies are inapplicable and provide guided workflow for the organization to set up new interaction control policies in governing the new device.

Abstract: The present injection apparatus is designed for replenishing embedded foundation preservation wraps with preservative whilst avoiding spillage. The injection apparatus comprises an injection bayonet having a lumen fluidly interfacing a plurality of preservative outlet nozzles along the injection bayonet and a preservative inlet fluidly interfacing the lumen. A portable preservative containing tank may be attached to the inlet via a flexible hose. The apparatus further comprises a syringe operating between the preservative inlet and the lumen. When replenishing the preservation wrap, the injection bayonet is inserted between the preservation wrap and the foundation so that preservative is configured to be supplied via the preservative inlet to flow out from the nozzles via the lumen to replenish the preservation wrap with the preservative. After replenishment, the lumen is purged of residual preservative using the syringe.

Abstract: A third-party server, delegated by organizations to manage application environment, may maintain a plurality of guided workflow plans. At least one of the guided workflow plans may include one or more steps associated with setting up an interaction control policy. The third-party server may receive an interaction report associated with the organization. The interaction report may include metadata of one or more devices that interacted with other devices. The third-party server may identify a particular device to which existing interaction control policies of the organization are inapplicable. The third-party server may search for additional out-of-band information of the particular device using the metadata in the interaction report. The third-party server may select an applicable guided workflow plan for setting up an applicable interaction control policy for the particular device. A guided workflow may be presented via a graphical user interface according to the applicable guided workflow plan.

Abstract: An application-operating organization may delegate a third-party server to serve as an automated contextual authentication responder and an authorization responder. The third-party server may manage a delegated section of the organization's namespace that includes the public identities of various devices controlled by the organization. The third-party server may also dynamically generate interaction control list that is tailored to a requesting device's context based on the interaction control policies set forth by the organization. The interaction control list may include information that determines the authorization of the requesting device to interact with another device. The third-party server may also automatically determine the role of a new device to which existing policies are inapplicable and provide guided workflow for the organization to set up new interaction control policies in governing the new device.

Abstract: A passive cathodic protection process for preservation of embedded metallic foundations entails embedding a wrap around a metallic foundation. The wrap has an outer sheath and an inner absorbent mat to be in direct contact with the metallic foundation. The is also mat hydrophobic. The wrap is subsumed such that an upper edge of the wrap is accessible. An oil-based metallic soap is injected via the upper edge to impregnate the mat. The metallic soap is selected from a set of metallic soaps such that the metal of the metallic soap is more electropositive than the metal of the metallic foundation such that the metallic soap acts as an anodic solution for galvanic exchange with metal within the embedded metallic foundation for the passive cathodic protection thereof. For example, zinc naphthenate may be selected for steel or aluminium foundations thereby allowing for both passive cathodic protection and biocidal action.

Abstract: A third-party server, delegated by organizations to manage application environment, may maintain a plurality of guided workflow plans. At least one of the guided workflow plans may include one or more steps associated with setting up an interaction control policy. The third-party server may receive an interaction report associated with the organization. The interaction report may include metadata of one or more devices that interacted with other devices. The third-party server may identify a particular device to which existing interaction control policies of the organization are inapplicable. The third-party server may search for additional out-of-band information of the particular device using the metadata in the interaction report. The third-party server may select an applicable guided workflow plan for setting up an applicable interaction control policy for the particular device. A guided workflow may be presented via a graphical user interface according to the applicable guided workflow plan.

Abstract: An application-operating organization may delegate a third-party server to serve as an automated contextual authentication responder and an authorization responder. The third-party server may manage a delegated section of the organization's namespace that includes the public identities of various devices controlled by the organization. The third-party server may also dynamically generate interaction control list that is tailored to a requesting device's context based on the interaction control policies set forth by the organization. The interaction control list may include information that determines the authorization of the requesting device to interact with another device. The third-party server may also automatically determine the role of a new device to which existing policies are inapplicable and provide guided workflow for the organization to set up new interaction control policies in governing the new device.

Abstract: A third-party server, delegated by organizations to manage application environment, may maintain a plurality of guided workflow plans. At least one of the guided workflow plans may include one or more steps associated with setting up an interaction control policy. The third-party server may receive an interaction report associated with the organization. The interaction report may include metadata of one or more devices that interacted with other devices. The third-party server may identify a particular device to which existing interaction control policies of the organization are inapplicable. The third-party server may search for additional out-of-band information of the particular device using the metadata in the interaction report. The third-party server may select an applicable guided workflow plan for setting up an applicable interaction control policy for the particular device. A guided workflow may be presented via a graphical user interface according to the applicable guided workflow plan.

Abstract: A third-party server, delegated by organizations to manage application environment, may maintain a plurality of guided workflow plans. At least one of the guided workflow plans may include one or more steps associated with setting up an interaction control policy. The third-party server may receive an interaction report associated with the organization. The interaction report may include metadata of one or more devices that interacted with other devices. The third-party server may identify a particular device to which existing interaction control policies of the organization are inapplicable. The third-party server may search for additional out-of-band information of the particular device using the metadata in the interaction report. The third-party server may select an applicable guided workflow plan for setting up an applicable interaction control policy for the particular device. A guided workflow may be presented via a graphical user interface according to the applicable guided workflow plan.

Abstract: The present disclosure relates generally to the field of mammalian prosthetics, and more specifically to prostheses for use in total or partial joint replacement, and to a method of use of these prostheses in arthroplasty. Thus, disclosed is a prosthesis for use in hip arthroplasty that comprises an artificial femoral head that includes a head portion constructed totally or partially of a polymeric material, and a connector means designed to connect said head portion in a non-articulating manner to a femoral stem portion. The head portion may be made solely of solid polymeric material or of an outer shell of polymeric material connected in a non-articulating manner to an embedded core. The polymeric material is preferably selected from ultra-high molecular weight polyethylene (UHMWPE) or radiation treated UHMWPE having substantially no detectable free radicals. The embedded core comprises, for example, one or more of solid non-polymeric material (e.g.

Abstract: A third-party server, delegated by organizations to manage application environment, may maintain a plurality of guided workflow plans. At least one of the guided workflow plans may include one or more steps associated with setting up an interaction control policy. The third-party server may receive an interaction report associated with the organization. The interaction report may include metadata of one or more devices that interacted with other devices. The third-party server may identify a particular device to which existing interaction control policies of the organization are inapplicable. The third-party server may search for additional out-of-band information of the particular device using the metadata in the interaction report. The third-party server may select an applicable guided workflow plan for setting up an applicable interaction control policy for the particular device. A guided workflow may be presented via a graphical user interface according to the applicable guided workflow plan.

Abstract: An application-operating organization may delegate a third-party server to serve as an automated contextual authentication responder and an authorization responder. The third-party server may manage a delegated section of the organization's namespace that includes the public identities of various devices controlled by the organization. The third-party server may also dynamically generate interaction control list that is tailored to a requesting device's context based on the interaction control policies set forth by the organization. The interaction control list may include information that determines the authorization of the requesting device to interact with another device. The third-party server may also automatically determine the role of a new device to which existing policies are inapplicable and provide guided workflow for the organization to set up new interaction control policies in governing the new device.

Abstract: An application-operating organization may delegate a third-party server to serve as an automated contextual authentication responder and an authorization responder. The third-party server may manage a delegated section of the organization's namespace that includes the public identities of various devices controlled by the organization. The third-party server may also dynamically generate interaction control list that is tailored to a requesting device's context based on the interaction control policies set forth by the organization. The interaction control list may include information that determines the authorization of the requesting device to interact with another device. The third-party server may also automatically determine the role of a new device to which existing policies are inapplicable and provide guided workflow for the organization to set up new interaction control policies in governing the new device.

Abstract: A passive cathodic protection process for preservation of em bedded metallic foundations entails embedding a wrap around a metallic foundation. The wrap has an outer sheath and an inner absorbent mat to be in direct contact with the metallic foundation. The is also mat hydrophobic. The wrap is subsumed such that an upper edge of the wrap is accessible. An oil-based metallic soap is injected via the upper edge to impregnate the mat. The metallic soap is selected from a set of metallic soaps such that the metal of the metallic soap is more electropositive than the metal of the metallic foundation such that the metallic soap acts as an anodic solution for galvanic exchange with metal within the em bedded metallic foundation for the passive cathodic protection thereof. For example, zinc naphthenate may be selected for steel or aluminium foundations thereby allowing for both passive cathodic protection and biocidal action.

Abstract: The present disclosure relates generally to the field of mammalian prosthetics, and more specifically to prostheses for use in total or partial joint replacement, and to a method of use of these prostheses in arthroplasty. Thus, disclosed is a prosthesis for use in hip arthroplasty that comprises an artificial femoral head that includes a head portion constructed totally or partially of a polymeric material, and a connector means designed to connect said head portion in a non-articulating manner to a femoral stem portion. The head portion may be made solely of solid polymeric material or of an outer shell of polymeric material connected in a non-articulating manner to an embedded core. The polymeric material is preferably selected from ultra-high molecular weight polyethylene (UHMWPE) or radiation treated UHMWPE having substantially no detectable free radicals. The embedded core comprises, for example, one or more of solid non-polymeric material (e.g.