Patents by Inventor William Alan Fox

William Alan Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200150008
    Abstract: An efficient manual method for preparing a cytology sample for staining. According to the method, a biological sample is provided, wherein the biological sample is a liquid-based cytology sample. A slide is placed in a holder adapted for receiving the slide. The slide is pre-coated with a composition that will cause cells to adhere to the slide. A settling chamber is placed over said slide and the settling chamber is locked onto the holder. The settling chamber has openings in both proximate and distal ends. The opening in the distal end of the settling chamber is positioned over the slide such that the slide is interposed between the holder and the settling chamber and the slide is in fluid communication with the settling chamber. A density reagent is then dispensed into the settling chamber. The liquid-based cytology sample is then dispensed into the settling chamber over the reagent. The assembly formed by the holder, slide and settling chamber (and its liquid contents) is placed in a centrifuge.
    Type: Application
    Filed: July 18, 2018
    Publication date: May 14, 2020
    Applicant: BECTON DICKINSON AND COMPANY
    Inventors: Ryan Callaghan, Clark M. Whitehead, William Alan Fox
  • Patent number: 10473034
    Abstract: According to an aspect, a system for a gas turbine engine includes a reduction gear train operable to drive rotation of a starter gear train that interfaces to an accessory gearbox of the gas turbine engine. The reduction gear train includes a starter interface gear that engages the starter gear train and a core-turning clutch operably connected to the starter interface gear. The reduction gear train also includes a geared rotary actuator including a primary planetary gear system, where the geared rotary actuator is operably connected to the core-turning clutch. The reduction gear train further includes a secondary planetary gear system operably connected to the primary planetary gear system and a core-turning input. The system also includes a mounting pad with an interface to couple a core-turning motor to the core-turning input of the reduction gear train.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: November 12, 2019
    Assignee: HAMILTON SUNDSTRAND CORPORATION
    Inventors: Benjamin T. Harder, Brian McMasters, James Vandung Nguyen, Dwayne Leon Wilson, Paul F. Fox, Richard Alan Davis, Richard R. Hergert, Jeffrey Todd Roberts, Jeff A. Brown, Daniel Richard Walker, Matthew Allen Slayter, William G. Sheridan
  • Publication number: 20180126343
    Abstract: A device for collecting a biological sample from a semi-solid surface. The device has a shaft with a proximate end and a distal end and a tip integrated with the shaft at the proximate end. The tip has a surface adapted to collect microorganisms thereon or release microorganism from, or both, wherein the adapted surface comprises at least one feature of a recess or extension to increase surface area of the tip and collect microorganisms thereon. Examples of such features include microfeatures with dimensions of about 1000 ?m or less. Other examples include a pipette tip.
    Type: Application
    Filed: April 8, 2016
    Publication date: May 10, 2018
    Applicant: Becton Dickinson and Company
    Inventors: Timothy Mark WILES, Dwight LIVINGSTON, Jennifer SINGELYN, William Alan FOX, Brian Reuben LANGHOFF, Vikram PATEL, Sean TUCKER, Ming-hsiung YEH, Michael A. BRASCH
  • Patent number: 9835528
    Abstract: A sample preparation device and associated method is provided for preparing samples according to an assay protocol. A cell deposition module deposits a sample on each of a plurality of assay devices supported by a support device. An epitope retrieval module deposits a reagent on each of the samples. Each of the samples is brought to a selected temperature. A heating device, corresponding to each of the assay devices, directly interacts with the corresponding assay device and may be used to heat each assay device to the selected temperature, in conjunction with the epitope retrieval module depositing the reagent on each of the samples. A staining module deposits a staining reagent on each of the samples, and removes excess staining reagent. The staining, epitope retrieval, and cell deposition modules cooperate with the support device and heating devices to form a unitary sample preparation device.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: December 5, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: William Alan Fox, Ryan Carl Williams, Brian Reuben Langhoff
  • Publication number: 20170307525
    Abstract: A nephelometer that measures turbidity of low volume suspensions using measurements of light transmitted through and/or scattered by the sample. The sample suspension is placed in a tiered cuvette adapted to facilitate measuring the turbidity of low volume samples. The lower portion of the cuvette has smaller dimensions, in horizontal cross section, than the top portion. Both lower and upper portions have angled surfaces. The lower, smaller portion of the cuvette is interrogated by the nephelometer.
    Type: Application
    Filed: September 29, 2015
    Publication date: October 26, 2017
    Applicant: BD Kiestra B.V.
    Inventors: Brian Reuben Langhoff, William Alan Fox, Kerry Lynn Smith
  • Patent number: 9770679
    Abstract: The invention provides a sequential centrifuge for centrifuging discrete samples. Methods of more efficiently centrifuging discrete samples sequentially are also provided. The apparatus and methods for sequentially centrifuging discrete samples provide improved operating efficiencies over conventional batch centrifuges. Such advantages include reducing dwell time, increasing system throughput, reducing sample processing system footprint, and improving precision of the analytical process. The sequential centrifuge further provides the capability of handling critical samples without compromising the operating efficiencies achieved in centrifuging discrete samples in a sequential manner.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: September 26, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: William Alan Fox, Charles L. Carrico
  • Publication number: 20170059457
    Abstract: A sample preparation device and associated method is provided for preparing samples according to an assay protocol. A cell deposition module deposits a sample on each a plurality of assay devices supported by a support device. An epitope retrieval module deposits a reagent on each of the samples. Each of the samples is brought to a selected temperature. A heating device, corresponding to each of the assay devices, directly interacts with the corresponding assay device may be used to heat each assay device to the selected temperature, in conjunction with the epitope retrieval module depositing the reagent on each of the samples. A staining module deposits a staining reagent on each of the samples, and removes excess staining reagent. The staining, epitope retrieval, and cell deposition modules cooperate with the support device and heating devices to form a unitary sample preparation device.
    Type: Application
    Filed: November 10, 2016
    Publication date: March 2, 2017
    Applicant: Becton, Dickinson and Company
    Inventors: William Alan Fox, Ryan Carl Williams, Brian Reuben Langhoff
  • Patent number: 9545634
    Abstract: A sample tube holder assembly may include a base comprising a base cavity defined therein. The sample tube holder assembly may include at least one first engagement member disposed within the base cavity and a plurality of sample tube holder racks configured to be received within the base cavity, at least one of the sample tube holder racks comprising at least one second engagement member, wherein each of the plurality of sample tube holder racks further comprises at least one sample tube cavity configured to receive a respective sample tube therein. The first and second engagement members may be configured to engage with one another when the plurality of sample tube holder racks are positioned within the base cavity such that the sample tube holder racks are offset at a different depth from one another within the base cavity.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: January 17, 2017
    Assignee: TriPath Imaging, Inc.
    Inventor: William Alan Fox
  • Patent number: 9528919
    Abstract: A sample preparation device and associated method is provided for preparing samples according to an assay protocol. A cell deposition module deposits a sample on each a plurality of assay devices supported by a support device. An epitope retrieval module deposits a reagent on each of the samples. Each of the samples is brought to a selected temperature. A heating device, corresponding to each of the assay devices, directly interacts with the corresponding assay device may be used to heat each assay device to the selected temperature, in conjunction with the epitope retrieval module depositing the reagent on each of the samples. A staining module deposits a staining reagent on each of the samples, and removes excess staining reagent. The staining, epitope retrieval, and cell deposition modules cooperate with the support device and heating devices to form a unitary sample preparation device.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: December 27, 2016
    Assignee: Becton, Dickinson and Company
    Inventors: William Alan Fox, Ryan Carl Williams, Brian Reuben Langhoff
  • Patent number: 9448246
    Abstract: The invention provides an integrated sequential sample preparation system using a sequential centrifuge for preparing samples for analysis. Methods of more efficiently preparing discrete samples sequentially for subsequent analysis are also provided. The apparatus and methods for sequentially preparing discrete samples provide improved operating efficiencies over conventional preparation processes that use batch centrifugation systems. Such advantages include reducing dwell time, increasing system throughput, reducing sample preparation system footprint, and improving precision of the analytical process. The integrated sequential preparation system with the integrated sequential centrifuge further provides the capability of handling critical or STAT samples without compromising the operating efficiencies achieved by preparing discrete samples in a sequential manner.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: September 20, 2016
    Assignee: TriPath Imaging, Inc.
    Inventors: William Alan Fox, Charles L. Carrico, Jr.
  • Publication number: 20160008745
    Abstract: The invention provides a sequential centrifuge for centrifuging discrete samples. Methods of more efficiently centrifuging discrete samples sequentially are also provided. The apparatus and methods for sequentially centrifuging discrete samples provide improved operating efficiencies over conventional batch centrifuges. Such advantages include reducing dwell time, increasing system throughput, reducing sample processing system footprint, and improving precision of the analytical process. The sequential centrifuge further provides the capability of handling critical samples without compromising the operating efficiencies achieved in centrifuging discrete samples in a sequential manner.
    Type: Application
    Filed: September 17, 2015
    Publication date: January 14, 2016
    Inventors: William Alan Fox, Charles L. Carrico
  • Publication number: 20150369708
    Abstract: The present subject matter is directed to a composition for staining cytological material comprising a cationic dye component, a hygroscopic polyol and optionally a water-soluble solvent, water or water-miscible solvent, methods of use of the compositions. Advantageously, the present compositions do not require the use of a cover slide as is required in known staining fixatives. The compositions are able to retain cell morphology for a period of time such that a cover slide is not required. Further, the compositions do not contain hazardous levels of organic components. Preferably, the compositions consist essentially of Azure C, glycerol and optionally water. In another aspect, the present subject matter is directed to a method of characterizing a cell sample comprising contacting the cell sample with a composition comprising a dye component and a hygroscopic polyol and subjecting the sample to analysis to determine the presence or absence of abnormal cells.
    Type: Application
    Filed: February 4, 2014
    Publication date: December 24, 2015
    Applicant: TriPath Imaging, Inc.
    Inventor: William Alan FOX
  • Patent number: 9211549
    Abstract: The invention provides a sequential centrifuge for centrifuging discrete samples. Methods of more efficiently centrifuging discrete samples sequentially are also provided. The apparatus and methods for sequentially centrifuging discrete samples provide improved operating efficiencies over conventional batch centrifuges. Such advantages include reducing dwell time, increasing system throughput, reducing sample processing system footprint, and improving precision of the analytical process. The sequential centrifuge further provides the capability of handling critical samples without compromising the operating efficiencies achieved in centrifuging discrete samples in a sequential manner.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: December 15, 2015
    Assignee: TriPath Imaging, Inc.
    Inventors: William Alan Fox, Charles L. Carrico
  • Publication number: 20150298131
    Abstract: A sample tube holder assembly may include a base comprising a base cavity defined therein. The sample tube holder assembly may include at least one first engagement member disposed within the base cavity and a plurality of sample tube holder racks configured to be received within the base cavity, at least one of the sample tube holder racks comprising at least one second engagement member, wherein each of the plurality of sample tube holder racks further comprises at least one sample tube cavity configured to receive a respective sample tube therein. The first and second engagement members may be configured to engage with one another when the plurality of sample tube holder racks are positioned within the base cavity such that the sample tube holder racks are offset at a different depth from one another within the base cavity.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 22, 2015
    Applicant: TRIPATH IMAGING, INC.
    Inventor: William Alan Fox
  • Publication number: 20150132798
    Abstract: The invention provides an integrated sequential sample preparation system using a sequential centrifuge for preparing samples for analysis. Methods of more efficiently preparing discrete samples sequentially for subsequent analysis are also provided. The apparatus and methods for sequentially preparing discrete samples provide improved operating efficiencies over conventional preparation processes that use batch centrifugation systems. Such advantages include reducing dwell time, increasing system throughput, reducing sample preparation system footprint, and improving precision of the analytical process. The integrated sequential preparation system with the integrated sequential centrifuge further provides the capability of handling critical or STAT samples without compromising the operating efficiencies achieved by preparing discrete samples in a sequential manner.
    Type: Application
    Filed: January 9, 2015
    Publication date: May 14, 2015
    Inventors: William Alan Fox, Charles L. Carrico, JR.
  • Patent number: 8956578
    Abstract: The invention provides an integrated sequential sample preparation system using a sequential centrifuge for preparing samples for analysis. Methods of more efficiently preparing discrete samples sequentially for subsequent analysis are also provided. The apparatus and methods for sequentially preparing discrete samples provide improved operating efficiencies over conventional preparation processes that use batch centrifugation systems. Such advantages include reducing dwell time, increasing system throughput, reducing sample preparation system footprint, and improving precision of the analytical process. The integrated sequential preparation system with the integrated sequential centrifuge further provides the capability of handling critical or STAT samples without compromising the operating efficiencies achieved by preparing discrete samples in a sequential manner.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: February 17, 2015
    Assignee: TriPath Imaging, Inc.
    Inventors: William Alan Fox, Charles L. Carrico, Jr.
  • Patent number: D808036
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: January 16, 2018
    Assignee: BD Kiestra B.V.
    Inventors: Brian Reuben Langhoff, William Alan Fox, Kerry Lynn Smith, Stefan Campbell Dehaseth
  • Patent number: D810959
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: February 20, 2018
    Assignee: BD Kiestra B.V.
    Inventors: Brian Reuben Langhoff, William Alan Fox, Kerry Lynn Smith, Stefan Campbell Dehaseth
  • Patent number: D831844
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 23, 2018
    Assignee: BD Kiestra B.V.
    Inventors: Brian Reuben Langhoff, William Alan Fox, Kerry Lynn Smith, Stefan Campbell Dehaseth
  • Patent number: D839448
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: January 29, 2019
    Assignee: BD Kiestra B.V.
    Inventors: Brian Reuben Langhoff, William Alan Fox, Kerry Lynn Smith, Stefan Campbell Dehaseth