Abstract: An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of o the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.

Abstract: Disclosed are fiber optic assemblies having at least one optical fiber and at least one water-swellable yarn disposed within a tube that preserves optical performance. Optical performance is preserved by selecting water-swellable yarns for the fiber optic assemblies that are softer and loftier since at least some of the filaments have a textured characteristic. In one embodiment, the water-swellable yarn has a stretch ratio of about 2 or more, where the stretch ratio is defined as the nominal unstretched diameter divided by the nominal stretched diameter. In another embodiment, the water-swellable yarn has a textured elongation factor of about 2% or more. Additionally, embodiments may position the optical fibers radially outward of the water swellable yarn(s), thereby further preserving optical performance.

Abstract: A global state management service manages replication in a distributed system. A distributed system can have several replica groups. The global state management service manages state associated with each replica group. Data replication is implemented without implementing an instance of a state machine on each device in a replica group. A replica group comprises a primary device and at least one secondary device. Each device in a replica group contains a replica of data of interest. The global state management service manages the allocation of primary and secondary devices. In the absence of a failure in either a primary device or a secondary device, read and write operations are performed without consulting the global state management service. When a failure is detected, the global state management service manages failover.

Abstract: A packetised data network includes IP telephones (ITs) and a network intelligence (NI). All of the keys of each IT are “soft” keys (i.e., they have no fixed function). The NI associates a configuration data structure with the IT which correlates the keys with functions, and, based on this, may control the display of the IT to indicate the current function of certain of the soft keys. Some of the functions are requests for data services at the telephone (e.g., video or programmed audio over the internet). When a user requests such a service with a key press, the NI sets up the service between the data source and the telephone. This may require associating a new configuration data structure with the keys of the IT. The IT user may activate multiple data services through the NI.

Abstract: A method is disclosed for preparing compounds of Formula 1 by combining compounds of Formulae 2 and 3 and a sulfonyl chloride. Also disclosed are compounds of Formula 3, which are useful as starting materials for this method.

Abstract: An electronic device is provided that includes a user-interface feature, a detection mechanism and one or more internal components. The user-interface feature is configurable to have a selected orientation about one or more axes. The detection mechanism can detect orientation information about the electronic device. The one or more components may select the orientation of the user-interface feature based on the detected orientation information.

Abstract: Disclosed herein is a polysiloxane/polyimide block copolymer having a siloxane content of 5 to 30 weight percent, based on the total weight of the block copolymer and comprising repeating units of Formula (I) wherein R1-6 are independently at each occurrence selected from the group consisting of substituted or unsubstituted, saturated, unsaturated or aromatic monocyclic and polycyclic groups having 5 to 30 carbon atoms, substituted or unsubstituted alkyl groups having 1 to 30 carbon atoms and substituted or unsubstituted alkenyl groups having 2 to 30 carbon atoms, V is a tetravalent linker selected from the group consisting of substituted or unsubstituted, saturated, unsaturated or aromatic monocyclic and polycyclic groups having 5 to 50 carbon atoms, substituted or unsubstituted alkyl groups having 1 to 30 carbon atoms, substituted or unsubstituted alkenyl groups having 2 to 30 carbon atoms and combinations comprising at least one of the foregoing linkers, g equals 1 to 30, and d is greater than or equ

Abstract: A steering column assembly includes a rake adjustment mechanism, and is attached to a vehicle by a mounting bracket. A rake bracket is coupled to the mounting bracket. A column jacket is collapsible in response to an emergency event and is supported by the mounting bracket and the rake bracket, and is rotationally moveable with the rake bracket about a rake axis relative to the mounting bracket. An instrument cluster is coupled to the rake bracket for movement along with the rake bracket and the column jacket to prevent obstruction of the instrument cluster by a steering wheel upon re-positioning the steering wheel, while not restricting movement of the column jacket during collapse of the column jacket in response to the emergency event. A dynamic absorber interconnects the instrument cluster and the rake bracket to reduce vibration of the steering column assembly caused by additional weight of the instrument cluster.

Abstract: A fractal fluid distribution system for use in a vessel is described wherein two phases are distributed separately and then finally mixed in a set of stacked fractal plates which are off set from one another by rotation around a central axis. Each of the two phases is fed from the top of the vessel. The flow paths of each individual phase have approximately the same length. A header is provided to allow feeding the two phases separately without interference with the final distribution outlets.

Abstract: A coprocessor (14) may be used to perform one or more specialized operations that can be off-loaded from a primary or general purpose processor (12). It is important to allow efficient communication and interfacing between the processor (12) and the coprocessor (14). In one embodiment, a coprocessor (14) generates and provides instructions (200, 220) to an instruction pipe (20) in the processor (12). Because the coprocessor (14) generated instructions are part of the standard instruction set of the processor (12), cache (70) coherency is easy to maintain. Also, circuitry (102) in coprocessor (14) may perform an operation on data while circuitry (106) in coprocessor (14) is concurrently generating processor instructions (200, 220).

Abstract: Embodiments of the present invention relate generally to regenerative vacuum generators for use on aircraft or other transportation vehicles. Embodiments of the invention further relate to modified regenerative vacuum generators that provide a larger area for air flow, as well as provide larger RPMs than typical regenerative vacuum generators. Further embodiments of the invention relate to modified regenerative vacuum generators for use on aircraft or other transportation vehicles. These features help generate high flow and vacuum in less time, which ensure a good vacuum system, and allow the generators to be much smaller than generators currently used in these applications.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: A filter bypass valve is disposed in parallel with an aircraft cabin air filtration system air filter. During normal operation, air is filtered through the air filter at an air flow that meets air flow requirements of the system. The bypass valve is designed to remain closed during normal use, and to open if the differential pressure across the air filter reaches a predetermined opening differential pressure to allow airflow to be partially or fully diverted around the air filter.

Abstract: Systems, methods and apparatus are provided for isolating a defect in a scan chain. The invention includes modifying a first test mode of a plurality of latches included in a scan chain, operating the latches in the modified first test mode, and operating the plurality of latches included in the scan chain in a second test mode. A portion of the scan chain adjacent and following a stuck-@-0 or stuck-@-1 fault in the scan chain may store and/or output a value complementary to the value on the output of the previous portion of the scan chain due to the fault. Such values may be unloaded from the scan chain and used for diagnosing (e.g., isolating a defect in) the defective scan chain. Numerous other aspects are provided.

Abstract: There is described in one embodiment an eye viewing device for viewing a structure of an eye such as a retina. The eye viewing device can include an image sensor. In one embodiment an eye viewing device can be adapted to facilitate both visual viewing of an eye structure and electronic image capture.

Abstract: There is described a fuel composition which is substantially free of alkoxylated compounds and is substantially free of long-chain alkyl alcohols having at least 6 C atoms, and contains at least 95% by volume of a hydrocarbon-based fuel and 0.1 to 5% by volume of an additive of the formula (I); R—CO—NR1R2 (I) in which R is a saturated or unsaturated, linear or branched alkyl radical having 6 to 21 C atoms; and R1 and R2, which may be the same or different, each represent a hydroxyalkyl radical having 1 to 4 atoms.

Abstract: An improved, load bearing, modular design container structure assembled from thermoformed FRTP sandwich panels in which is utilized the unique core-skin edge configuration of the present invention in consideration of improved load bearing performance, improved useful load volume, reduced manufacturing costs, structural weight savings, impact and damage tolerance and repair and replace issues.

Abstract: Battery life in portable entertainment devices that play fixed-length music or video files (e.g., MP3 music files) is extended by adaptively adjusting the speed of a processor in the device such that only a minimum number of MIPS are performed to playback the music or video files. Slowing the processor clock provides significant savings in power usage. A use profile containing required MIPS for each song may be stored on the device, or use profile information may be inserted into the data stream or embedded within the data file. Power savings occurs on every subsequent replay of the same entertainment data file or data stream by adaptively adjusting the processor clock to the desired speed as determined by the use profile information (plus design margin based on the particular playback device).