Abstract: Provided are anti-ABCB 1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB 1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies and multi-specific antibodies. Further included are uses and methods of treating conditions where inhibition of ABCB 1-mediated efflux transport is desirable, such as, cancer or multi-drug resistance mediated by the ABCB1 transporter, e.g., multi-drug resistant cancer. In particular, the disclosure provides humanized multi-specific, e.g. bispecific, IgG (IgG1) antibodies that bind ABCB1 and a TAA. Multi-specific IgG1 antibody molecules are provided with Fc substitutions in at least one of a first and a second heavy chain constant region.

Abstract: Various embodiments provide an integrated carbon capture, utilization and storage (CCUS) process that can convert CO2 to Group 2 carbonates and subsequent encapsulation and sequestration process to convert the carbonates to commercially useful aggregate, useful in plastics, building materials, mineral boards, concrete and road materials and make a feedstock of water useful for carbon neutral or carbon negative chloralkali and green hydrogen manufacture.

Abstract: Described herein are systems and methods for verifying the integrity of data, such as data used for training machine learning models. Some implementations are directed to verifying the provenance of datasets, the contents of datasets, or both. In some implementations, multiple filters are selected for verifying the contents of datasets. Filters can be selected based on rules, random selection, or using a machine learning model in some implementations. In some implementations, data cleaning is provided.

Abstract: A system and method for secure permissioning of access to user accounts, including secure distribution of aggregated user account data can include generating a financial report based on account information associated with one or more user accounts; receiving a financial report request for the financial report of the user account, wherein the financial report request is identified as being received from a third-party system; generating an audit report token associated with the financial report; sharing the audit token with the first third-party system in response to the financial report request; and providing the first third-party system account access to the financial report through the report token, where the audit report token can be shared with a second third-party system and provided by the second third-party system in order to confirm authorization to the report and integrity of the report.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a computer chip floorplan. One of the methods includes obtaining netlist data for a computer chip; and generating a computer chip floorplan, comprising placing a respective node at each time step in a sequence comprising a plurality of time steps, the placing comprising, for each time step: generating an input representation for the time step; processing the input representation using a node placement neural network having a plurality of network parameters, wherein the node placement neural network is configured to process the input representation in accordance with current values of the network parameters to generate a score distribution over a plurality of positions on the surface of the computer chip; and assigning the node to be placed at the time step to a position from the plurality of positions using the score distribution.

Abstract: A system may include a physically secure environment configured to receive precious metal thereto, to retain precious metal therein, and release precious metal therefrom. A system may include a registration system configured to record and maintain records containing unique precious metal identification information, physically secure location information of precious metal, lot identification information of precious metal, and one of certification information or de-processing information of precious metal. A system may include allocating a portion of a total quantity of certified standard uniform characteristic (SUC) precious metal units in a first location within the physically secure environment to be associated with a first lot and creating a first private registry with corresponding records associated with the allocated portion of certified SUC precious metal units in the first location.

Abstract: A method is provided for generating a dynamic image object (DIO), comprising: generating a synthetic image from a first image and a second image; storing the synthetic image within a DIO; and generating a display image based on the DIO and a viewing parameter.

Abstract: In one embodiment, a method may receive a first notification message associated with an instance of an edge application at an edge site of an edge network. The method may receive a subset of a unique identifier associated with the instance of the edge application from an application processing interface (API) router agent associated with the edge application. The method may use the subset of the unique identifier to determine a complete unique identifier associated with the instance of the edge application. The method may generate a second notification message corresponding to an API call using the complete unique identifier. The method may determine a network connection with the API router agent associated with the edge application. In response to determining the network connection is stable, the method may expose the second notification message to the API router agent associated with the edge application.

Abstract: A computer system, while displaying a first view of a three-dimensional environment that corresponds to a first viewpoint of a user, displays a first user interface object at a first position in the three-dimensional environment that has a first spatial relationship with the first viewpoint of the user. While displaying the first view of the three-dimensional environment including the first user interface object at the first position in the three-dimensional environment, the computer system, in response to detecting a first input that is directed to at least a first portion of the first user interface object, displays a second user interface object at a second position in the three-dimensional environment and moves the first user interface object from the first position to a third position in the three-dimensional environment that has a greater distance from the first viewpoint of the user than the first position in the three-dimensional environment.

Abstract: A system configured to characterize a physical motion performed by a user is disclosed herein. The system can include a wearable article including a first flexible circuit, that includes a first trace formed from a deformable conductor. The first flexible circuit is positioned in a first location of interest on the wearable article. The system can further include a computing device configured to receive a first signal generated by the first flexible circuit, determine a first electrical parameter based on the first signal, determine a physical condition of the first flexible circuit based on the first electrical parameter, compare the physical condition of the first flexible circuit to previously determined physical conditions associated with the wearable article, and characterize the physical motion performed by the user based on the comparison.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing a machine learning task on a network input to generate a network output. In one aspect, one of the systems includes a neural network configured to perform the machine learning task, the neural network including one or more switch layers.

Abstract: This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In some implementations, a heart valve leaflet clipping mechanism includes a delivery apparatus and clipping arms. The clipping arms are coupled to the delivery apparatus. The clipping arms are movable between an open position and a closed position. The two clipping arms are biased to the closed position. The delivery apparatus is configured to hold the clipping arms in the open position. The delivery apparatus is configured to allow the clipping arms to move to the closed position to engage native heart valve leaflet tissue.

Abstract: In one embodiment, a method by a runtime configuration service at an edge site comprises receiving a registration request from a particular application comprising a particular identifier associated with the particular application, establishing a connection to a control plane application programming interface (API) gateway located in an edge backend, sending a state request message to the API gateway comprising a site identifier and the particular identifier, receiving a state response message from the API gateway comprising a desired state for the particular application, storing a desired state for the particular application, and sending a notification to the particular application indicating an updated desired state for the particular application is available.

Abstract: Configurable product return determination includes maintaining product profiles indicating updated configurations of products and their components, building and training a set of models configured to identify products that are expected returns, predict retention times for such products, and determine, based on quality indicators of the products and on requirements for reusability of components, reusable components of the products, and, using the set of models and a product profile of a product in use, determining that the product in use is expected to be returned in the future and an expected timeframe of the return of the product in use, and determining one or more components, of a set of components of the product in use, that are reusable upon return of the product in the future.

Abstract: A system for improved remote processing and interaction with an artificial survey administrator is disclosed. The system has user-defined data storage containing lists of entities and attributes and correlation data with terms that correspond to the entities and attributes. An open-ended question generation module is present that provides an open-ended question over a network to a consumer of the specific good or service located remotely from the processor, the open-ended question being directed to the consumer's experience with said good or service A consumer response module is presented.

Abstract: A system and method for improved, non-intrusive material identification includes a vessel holding or transporting at least one quantity of a fluid. At least one acoustic transducer is positioned on an exterior surface of a sidewall of the vessel. At least one coupling layer is positioned between the at least one acoustic transducer and the exterior surface of the sidewall of the vessel, wherein the at least one coupling layer is formed, at least in part, from nanotubes, wherein the nanotubes improve a reflection of an acoustic signal emitted from the at least one acoustic transducer. A computerized device is in communication with the at least one acoustic signal. The computerized device has a processor and a memory, and determines a material identification of the quantity of fluid based on, at least in part, the reflection of the ultrasonic signal.

Abstract: A method relating to determining similarities between media, and systems and computer-readable media used to implement said method, includes determining an input image for comparison with a plurality of stored images in a media database; vectorising the input image to determine an input image vector representation; and comparing the input image with each of the plurality of stored images in a media database. The method further comprises outputting a set of direct matches and a set of exact matches as a detected comparison output for the input image. Further embodiments also relate to systems and methods for associating digital media with provenance information and creating verified copyright assets for attributing copyright ownership using the systems and methods disclosed herein.

Abstract: A method of obtaining a measurement of a part using depth data from a plurality of sensors comprises obtaining first depth data of a monument and a part from a first sensor and second depth data of the monument and the part from a second sensor. A plurality of planes is detected in the first depth data and the second depth data. Each plane of the plurality of planes corresponds to a corresponding face on the monument. The method comprises performing a rotational alignment of the plurality of planes. The method further comprises performing a translational alignment of the rotationally aligned plurality of planes. One or more transformations are determined that align the first depth data and the second depth data to a common coordinate system based upon the rotational alignment and the translational alignment. A measurement of the part is determined based upon aligned depth data.

Abstract: Methods and systems are described herein for enabling aerial vehicle navigation in GPS-denied areas. The system may use a camera to record images of terrain as the aerial vehicle is flying to a target location. The system may then detect (e.g., using a machine learning model) objects within those images and compare those objects with objects within an electronic map that was loaded onto the aerial vehicle. When the system finds one or more objects within the electronic map that match the objects detected within the recorded images, the system may retrieve locations (e.g., GPS coordinates) of the objects within the electronic map and calculate, based on the coordinates, the location of the aerial vehicle. Once the location of the aerial vehicle is determined, the system may navigate to a target location or otherwise adjust a flight path of the aerial vehicle.

Abstract: An apparatus comprises a vacuum chamber configured to produce a substantially atmospheric vacuum environment for plasma processing; a radio frequency (RF) power supply located outside of the vacuum chamber; an RF matching network operatively coupled to the RF power supply; and a plurality of electrodes mounted within the vacuum chamber, the plurality of electrodes configured to receive RF power signals from the RF power supply through the RF matching network. The RF power signals are simultaneously delivered to the plurality of electrodes during a sputtering operation. The plurality of electrodes and a set of electrical components are operative to manage the inductive and capacitive reactance for coupling the RF power signals to provide more desirable plasma coupling during the sputtering operation.