Abstract: A system for detecting EFL of a patient is provided. The system comprises an inhalation passage; an exhalation passage; a sensor for measuring flow-volume information of the exhaled air through an exhalation passage; a flow resistor positioned in the exhalation passage and being adjustable to provide an exhalation resistance in the exhalation passage; and a computer system. In one embodiment, one or more physical processors of the computer system are programmed with computer program instructions which, when executed cause the computer system to: determine a reference expiratory flow-volume curve using flow-volume information of the exhaled air through the exhalation passage when a reference exhalation resistance is provided by the flow resistor in the exhalation passage; and determine a perturbed expiratory flow-volume curve using flow-volume information of the exhaled air through the exhalation passage when a lowered exhalation resistance is provided by the flow resistor in the exhalation passage.

Abstract: The present disclosure pertains to a pressure support system configured to identify respiratory events of a subject. The system is configured to produce and analyze signals pertaining to one or more parameters of the pressurized flow of breathable gas to identify respiratory events. The respiratory events may include coughs and/or other respiratory events. The parameters may comprise a pressure, flow and/or volume of the pressurized flow of breathable gas. In some embodiments, cough detection may be based on a vibration in pressure, a negative spike in flow, a cessation in flow, and/or a large insufflation. In some embodiments, the system comprises one or more of a pressure generator, a subject interface, one or more sensors, a processor, a user interface, electronic storage, and/or other components.

Abstract: The present disclosure pertains to a mechanical ventilator system configured to deliver a pressurized flow of breathable gas to the airway of a subject. The system is configured to generate the pressurized flow of breathable gas according to a volume control mode therapy regime that delivers a target tidal volume to the subject during inhalation. During an individual inhalation, the system is configured to determine and/or adjust an inspiratory pressure level of the pressurized flow of breathable gas of the volume control mode therapy regime. The inspiratory pressure level is adjusted such that during the inhalation the inspiratory pressure level is not reduced to impede respiratory effort by the subject responsive to the target tidal volume being exceeded during the inhalation. The system comprises one or more of a pressure generator, a subject interface, one or more sensors, one or more processors, a user interface, electronic storage, and/or other components.

Abstract: A ventilator that is small, lightweight, and portable, yet capable of being quickly adapted to operate in a plurality of different modes and configurations to deliver a variety of therapies to a patent. A porting system having a plurality of sensors structured to monitor a number of parameters with respect to the flow of gas, and a number of porting blocks is used to reconfigure the ventilator so that it operates as a single-limb or dual limb ventilator. In the single-limb configuration, an active or passive exhaust assembly can be provided proximate to the patient. The ventilator is capable of operate in a volume or pressure support mode, even in a single-limb configuration. In addition, a power control mechanism controls the supply of power to the ventilator from an AC power source, a lead acid battery, an internal rechargeable battery pack, and a detachable battery pack.

Abstract: The present disclosure pertains to a system and a method for expiratory flow limitation (EFL) detection by controlling positive pressure (e.g., PEEP) applied during expiration for a subject. The technique is based on a temporary perturbation or adjustment of a pressure level of positive pressure during exhalation on selected breaths. The different response to such a perturbation that flow-limited breaths have compared to non-flow limited breaths is exploited to assess EFL in a subject. Adjustments of positive pressure applied to the patient are used in the disclosed algorithm to abolish EFL. The algorithm can be implemented in existing ventilators and other respiratory devices.

Abstract: The present disclosure pertains to a mechanical ventilator system configured to control a pressurized flow of breathable gas for delivery to a subject based on alveolar ventilation of the subject. The mechanical ventilator system comprises a pressure generator configured to generate the pressurized flow of breathable gas for delivery to the subject, the pressure generator configured to control one or more ventilation parameters of the pressurized flow of breathable gas according to a prescribed mechanical ventilation therapy regime; one or more sensors configured to generate output signals conveying information related to the alveolar ventilation of the subject; and one or more hardware processors configured by machine-readable instructions to: determine the alveolar ventilation of the subject based on the output signals; and cause the pressure generator to adjust the one or more ventilation parameters of the pressurized flow of breathable gas based on the determined alveolar ventilation.

Abstract: The present disclosure pertains to a method and system configured for detecting a gas delivery malfunction in a spontaneous mechanical ventilation mode. In some embodiments, the system comprises a pressure generator, a subject interface, one or more sensors, one or more processors, electronic storage, a user interface, and/or other components. The detection of a gas delivery malfunction in a spontaneous mechanical ventilation mode is implemented by generating a test flow of gas for delivery to an airway of a subject, and monitoring a responsive flow of gas in the subject interface. If one or more parameters associated with the responsive flow of gas demonstrate inconsistencies with a reference flow of gas responsive to the test flow under a condition that there is no gas delivery malfunction, the system determines that there is a gas delivery malfunction.

Abstract: Systems and methods to estimate, on a breath-by-breath basis, the fraction of inhaled oxygen during ventilation of a subject. The fraction of inhaled oxygen may be based on exhaled tidal volume, a volume of dead space within the subject interface, leaked exhalation volume, and subsequently inhaled tidal volume and leaked inhalation volume.

Abstract: The present disclosure pertains to a system for controlling a leak flow rate during respiratory therapy. The system is configured to determine a leak flow rate necessary for CO2 expulsion for an individual subject and facilitate control of the leak flow rate during therapy such that the system exhausts substantially the entire exhaled volume of gas during an expiration of the subject. The system facilitates control of the leak flow rate during therapy via an adjustable leak valve. Determining the leak flow rate for the subject and facilitating control of the leak rate may minimize noise from air flow in the system, minimize the power draw needed by a pressure generator of the system, reduce a loss of medicine added to the respiratory therapy gas, and/or have other advantages, while still expelling the desired amount of CO2.

Abstract: The present disclosure pertains to a system configured to detect slow waves in a subject during a sleep session. The system generates output signals conveying information related to brain activity of the subject. The system is configured to detect individual sleep stages of the subject, the individual sleep stages including a deep sleep stage; and, responsive to detecting the deep sleep stage, generate a harmonic representation of the output signals for a period of time during the sleep session that includes the deep sleep stage; identify two or more points of significance on the harmonic representation of the output signals; and analyze a shape of the harmonic representation of the output signals around the two or more points of significance to determine whether the shape of the harmonic representation of the output signals around the two or more points of significance corresponds to a shape of a slow wave.

Abstract: Systems and methods provide respiratory therapy to a subject through a pressurized flow of breathable gas. Timing and other characteristics of pressure and flow levels provided during inhalations and exhalations are adjusted in order to increase the volumetric rate of expulsion of CO2.

Abstract: A system (10) for measuring subject flow in a respiratory therapy device. The system may include a primary pressure generator (12) connected to a subject circuit (18), and a secondary pressure generator (30) connected to a sensor circuit (36). The sensor circuit and subject circuit may be in fluid communication such that gas form the sensor circuit is introduced into the subject circuit. A measurement of flow parameters of gas through the sensor circuit may convey information related to flow parameters of gas in the subject circuit. The system may be configured such that contaminates from subject flow in the subject circuit do not flow into the sensor circuit.

Abstract: A pressure control ventilation system (10) configured to provide airway release ventilation synchronous with a breathing subject that includes a pressure generator (12) configured to generate pressurized flow of breathable gas to a subject, one or more sensors (28) configured to generate output signals conveying information related to one or more gas parameters of the pressurized flow, one or more processors (14) configured to execute computer modules comprising: a synchronization module (16) configured to detect inspiratory (39, 45) and expiratory (40, 44, 59) flow phases of the subject based at least on the signals; an interval module (18) configured to define time intervals (54, 60); a control module (20) configured to control the generator to deliver flow fluctuating between a first pressure range (48) to maintain adequate lung volume and a second pressure range (50) to facilitate C02 exhalation, the control including: delivering the flow in the first range at the beginning (56) of a first time interval (

Abstract: The present disclosure pertains to a pressure support system (10) configured to deliver a pressurized flow of breathable gas to the airway of a subject (12), the pressure support system comprising: a pressure generator (14) configured to generate the pressurized flow of breathable gas; one or more sensors (18) configured to generate output signals conveying information related to whether the subject is ready to receive breath stacking therapy; and one or more processors (20) configured to execute computer program modules, the computer program modules comprising:—a control module (52) configured to control the pressure generator to generate the pressurized flow of breathable gas according to a pressure control therapy regime,—an event module (54) configured to determine breath stacking events responsive to the output signals indicating that the subject is ready to receive breath stacking therapy, and—a breath stacking module (56) configured to, responsive to the determination of a breath stacking event, contro

Abstract: Systems and methods for providing respiratory support to a subject by intermittently delivering pressurized flow of breathable gas to a subject are described. A system may include, for example, a pressure generator, an interface appliance configured to communicate a flow of gas generated by the pressure generator to an airway of the subject, one or more sensors, and one or more processors configured to execute one or more computer program modules. The computer program modules may be configured, for example, to determine whether the subject is ready to receive the pressurized flow of breathable gas, to initiate and/or terminate delivery of the pressurized flow of breathable gas to the airway of the subject, and to control the pressure generator and the interface appliance so as to appropriately deliver the pressurized flow of breathable gas based on a prescribed therapy regimen designed to ventilate the subject.

Abstract: The present disclosure pertains to a mechanical ventilator system configured to deliver a pressurized flow of breathable gas to the airway of a subject. The system is configured to generate the pressurized flow of breathable gas according to a volume control mode therapy regime that delivers a target tidal volume to the subject during inhalation. During an individual inhalation, the system is configured to determine and/or adjust an inspiratory pressure level of the pressurized flow of breathable gas of the volume control mode therapy regime. The inspiratory pressure level is adjusted such that during the inhalation the inspiratory pressure level is not reduced to impede respiratory effort by the subject responsive to the target tidal volume being exceeded during the inhalation. The system comprises one or more of a pressure generator, a subject interface, one or more sensors, one or more processors, a user interface, electronic storage, and/or other components.

Abstract: A flow of breathable gas is delivered to a subject through a patient interface assembly. An enhanced technique for determining whether the airway of subject is disengaged from the patient interface assembly. A model that provides predicted values of a dynamic property of the flow of breathable gas is fit to measured values of the dynamic property. The model and/or the fit of the predicted values to the measured values are then analyzed to determine whether or not the airway of the subject is disengaged from the patient interface assembly. This provide enhanced determination of these conditions even in implementations in which a restrictive patient interface assembly is used.

Abstract: Systems and methods to estimate, on a breath-by-breath basis, the fraction of inhaled oxygen during ventilation of a subject. The fraction of inhaled oxygen may be based on exhaled tidal volume, a volume of dead space within the subject interface, leaked exhalation volume, and subsequently inhaled tidal volume and leaked inhalation volume.