Patents by Inventor William Arthur Metz, Jr.

William Arthur Metz, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase I
    Patent number: 8008340
    Abstract: A method for inhibiting casein kinase I? activity, comprising administering to said patient a therapeutically effective amount of a compound of formula I. its stereoisomer, enantiomer, racemate, tautomer or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: August 30, 2011
    Assignee: Aventis Pharmaceuticals Inc.
    Inventor: William Arthur Metz, Jr.
  • 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I
    Patent number: 7923466
    Abstract: Methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase I? activity comprising the administration of a compounds of formula (I) and formula (II) as inhibitors of human casein kinase I?, and methods of using the compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) useful in the claimed methods of treatment are also disclosed.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: April 12, 2011
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: William Arthur Metz, Jr., Fa-Xiang Ding
  • 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I
    Patent number: 7629376
    Abstract: The present invention discloses and claims compounds of formula (I) and formula (II) as inhibitors of human casein kinase I?, and methods of using the compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) are also disclosed and claimed.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: December 8, 2009
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: William Arthur Metz, Jr., Fa-Xiang Ding
  • 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I
    Publication number: 20090082340
    Abstract: The present invention discloses and claims methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase I? activity comprising the administration of a compounds of formula (I) and formula (II) as inhibitors of human casein kinase I?, and methods of using said compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) useful in the claimed methods of treatment are also disclosed.
    Type: Application
    Filed: November 12, 2008
    Publication date: March 26, 2009
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: William Arthur METZ, JR., Fa-Xiang Ding