Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: A method includes providing a cartridge and the cartridge includes a slot for receiving a microfluidic chip having a set of first channels. The cartridge also includes a set of second channels and each channel of the set of second channels is coupleable to a different channel of the set of first channels during use with the microfluidic chip. The cartridge also includes an indent configured for engagement and alignment of the cartridge during use. The method also includes inserting the cartridge into a device, such that the cartridge engages a first biasing member of the device configured for alignment of the cartridge in a first direction. The first biasing member is configured to bias movement of the cartridge into locking position with a notch of the device.

Abstract: An assist apparatus utilized within a door system to aid in opening the door. The assist apparatus may include one or more door activation devices (e.g., a first door activation device and a second door activation device, such as pulls on opposite sides of a sliding door) that can rotate around a pivot location. Moreover, the assist apparatus may further include one or more assist components operatively coupled to the one or more door activation devices. The door activation device(s) are configured to be operatively coupled to a sliding door and allow for rotation of at least a portion of the door activation device. The assist component(s) of the door activation device(s) aid in opening or closing the sliding door by engaging a door frame, wall, or the like as the door activation device is rotated.

Abstract: The unified system for bimanual interactions provides a lightweight and integrated interface that allows the user to efficiently interact with and manipulate content in the user interface. The system is configured to detect a multi-finger interaction on the touchscreen and to differentiate whether the user intends to pan, zoom or frame a portion of the user interface. Generally, the framing interaction is identified by detection of the user's thumb and forefinger on the touchscreen, which cooperate to define a focus area between vectors extending outwards from the user's thumb and forefinger. Upon a determination that the user intends to interact with or manipulate content within the focus area, the unified system for bimanual interactions provides an indication of the objects that are located within the focus area and contextual menus for interacting with the objects.

Abstract: The invention provides humanized antibodies that specifically bind to LIV-1. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting LIV-1.

Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: Thumb+pen inputs are described herein, to improve the functionality of touch enabled devices for accepting bimanual input in situations where the device is gripped or supported by one of the user's hands, leaving only one hand free. The thumb of an engaging hand is identified and controls are placed within its range of motion to enhance the functionality provided by the free hand. The actions of the thumb can be used to determine how pen actions made using the other hand are interpreted. Alternatively, the pen can indicate an object through pointing, while the thumb indirectly manipulates one or more of its parameters through touch controls. Marking menus, spring-loaded modes, indirect input, and conventional multi-touch interfaces are applied with respect to the bimanual input mode in which one hand is positioned to hold or support the device, and the other hand is free to improve device operability and accessibility.

Abstract: Alloys, processes for preparing the alloys, and articles including the alloys are provided. The alloys can include, by weight, about 0.01% to about 1% vanadium, 0% to about 0.04% carbon, 0% to about 8% niobium, 0% to about 1% titanium, 0% to about 0.04% boron, 0% to about 1% tungsten, 0% to about 1% tantalum, 0% to about 1% hafnium, and 0% to about 1% ruthenium, the balance essentially molybdenum and incidental elements and impurities.

Abstract: Techniques for coordinating a message experience across platforms are described. In one embodiment, an apparatus may comprise a messaging application operative on a processor circuit to receive a request from a remote web browser to login to the messaging application. The messaging application may comprise an access code generator to generate a first access code and present the first access code on a messaging application website; an authenticator to receive a second access code from a second device associated with a user identifier, compare the second and first access codes, and lookup an account associated with the user identifier; and a messaging component to retrieve message data for an account associated with the user identifier in response the second access code matching the first access code, and to transmit the message data to the remote web browser for presentation. Other embodiments are described and claimed.

Abstract: A computer-implemented method is provided for implementing wind correction for a projectile launching gun aiming at a target on a gun fire control system on an aircraft. The fire control method includes obtaining first physical parameters; executing a ballistics model to obtain a flight path of the projectile; obtaining number of points for wind direction and velocity across altitudes; executing a tracker model to obtain tracker location and initial gun state; obtaining closure tolerance and cross-correlation factor; modeling wind prediction to obtain a predicted wind column; incorporating the predicted wind column for wind column prediction for a projectile effect; and applying the projectile effect to the fire-control processor to adjust aiming the gun. The first physical parameters include wind column, gun state, ammunition type and aircraft flight conditions. The ballistics model obtains a flight path of the projectile based on the first physical parameters.

Abstract: A computer-implemented method is provided for implementing wind correction for a projectile launching gun aiming at a target on a gun fire control system on an aircraft. The fire control method includes obtaining first physical parameters; executing a ballistics model to obtain a flight path of the projectile; obtaining number of points for wind direction and velocity across altitudes; executing a tracker model to obtain tracker location and initial gun state; obtaining closure tolerance and cross-correlation factor; modeling wind prediction to obtain a predicted wind column; incorporating the predicted wind column for wind column prediction for a projectile effect; and applying the projectile effect to the fire-control processor to adjust aiming the gun. The first physical parameters include wind column, gun state, ammunition type and aircraft flight conditions. The ballistics model obtains a flight path of the projectile based on the first physical parameters.

Abstract: In one embodiment, a method includes displaying a virtual keyboard at a first position within a virtual scene that is visible to a user through a display, detecting that the user touches a first point on a trackpad of a controller that is associated with the display, re-positioning, in response to the detection, the virtual keyboard from the first position to a second position, where the second position is determined based on the first point on the trackpad, and displaying, in response to the detection, a pointing indicator, where the pointing indicator is displayed on top of the virtual keyboard, and where the pointing indicator represents that an area of the virtual keyboard indicated by the pointing indicator is being pointed by the user.

Abstract: A battery having a cathode and a composite anode is provided. In one embodiment, the composite anode may include a lithium metal anode, a solid electrolyte and at least one interface layer. The interface layer improves the uniformity of the surface of the solid electrolyte thereby optimizing contact between the surface of the lithium metal anode and the surface of the solid electrolyte for better battery performance. The anode and/or the interface may be formed of a printable lithium composition including lithium metal powder, a polymer binder compatible with the lithium metal powder, a rheology modifier compatible with the lithium metal powder, and a solvent compatible with the lithium metal powder and with the polymer binder. The cathode may be a composite cathode. In another embodiment, the printable lithium composition may be in the form of a foil or film.

Abstract: The unified system for bimanual interactions provides a lightweight and integrated interface that allows the user to efficiently interact with and manipulate content in the user interface. The system is configured to detect a multi-finger interaction on the touchscreen and to differentiate whether the user intends to pan, zoom or frame a portion of the user interface. Generally, the framing interaction is identified by detection of the user's thumb and forefinger on the touchscreen, which cooperate to define a focus area between vectors extending outwards from the user's thumb and forefinger. Upon a determination that the user intends to interact with or manipulate content within the focus area, the unified system for bimanual interactions provides an indication of the objects that are located within the focus area and contextual menus for interacting with the objects.

Abstract: A pre-sintered all-solid-state battery comprises a powdered lithium titanate (LTO), a powdered lithium lanthanum titanium oxide (LLTO), and a solid lithium compound configured to suppress formation of inactive phases during sintering. The solid lithium compound is about 0.5% to 10% by weight of the pre-sintered all-solid-state battery.

Abstract: A substrate coated with a printable lithium composition is provided. The printable lithium composition includes lithium metal powder; a polymer binder, wherein the polymer binder is compatible with the lithium powder; and a rheology modifier compatible with the lithium powder and the polymer binder, wherein the rheology modifier is dispersible within the composition and provides a three-dimensional support structure for further improvement of the electrochemical performance of the electrode when coated with the composition. The substrate may be incorporated into a battery. In one embodiment, the battery comprises a cathode, an electrolyte and an anode, wherein the cathode, the electrolyte, the separator, the anode, or a combination thereof may each comprise a substrate coated with a printable lithium composition.

Abstract: A printable lithium composition is provided. The printable lithium composition includes lithium metal powder; a polymer binder, wherein the polymer binder is compatible with the lithium powder; and a rheology modifier, wherein the rheology modifier is compatible with the lithium powder and the polymer binder. The printable lithium composition may further include a solvent compatible with the lithium powder and with the polymer binder.

Abstract: Laser sensor lenses and methods for maintaining clean laser sensors lenses are disclosed. One method may include applying a coating having first and second components to an exterior surface of a lens of a laser sensor, the first component including a thermogenic light-absorbing (TLA) material; and irradiating the TLA material from a light source within the laser sensor to generate heat from the TLA material to cause the second component to form an active coating. The light source may be a laser of a LiDAR sensor. The heat from the TLA material may cause the second component to cure, solidify, or undergo a phase change. The active coating may be at least one of hydrophobic, oleophobic, and hydrophilic. In another embodiment, a removable cover having a TLA material may be positioned proximate the lens window and irradiated to heat the lens window (e.g., to melt ice thereon).

Abstract: In one embodiment, a method includes displaying a horizontal screen visible to a user through a display, determining a horizontal distance between a position of the user and the horizontal screen, determining a vertical distance between a controller associated with the user and the horizontal screen, creating an interaction screen, where the interaction screen and the horizontal screen intersect in a closest point, where the interaction screen is tilted toward the user from the horizontal screen by an angle, detecting a first event that a ray cast from a virtual representation of the controller hits a first point on the interaction screen, translating the first event to a second event that the ray cast hits a second point on the horizontal screen, and displaying a curved line from the controller to the second point on the horizontal screen that is visible to the user through the display.

Abstract: The present disclosure is directed to systems and methods for validating wind farm performance improvements so as to optimize wind farm performance. In one embodiment, the method includes operating, via a controller, the wind farm in a first operating mode. Another step includes collecting a first set of operating data, via a processor, during the first operating mode. A further step includes operating, via the controller, the wind farm in a second operating mode. The method also includes collecting a second set of operating data, via the processor, during the second operating mode. Next, the method includes normalizing the first and second sets of operating data based on wind speed distributions. As such, another step includes comparing, via the processor, the normalized first and second sets of operating data so as to validate one or more wind farm performance measurements.