Patents by Inventor William B. Geiss

William B. Geiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
    Patent number: 9422266
    Abstract: Substituted cyclopropyl compounds of the formula I and the pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included. Another aspect of the invention that is of interest relates to compounds of formula 1a.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: August 23, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Michael W. Miller, Andrew W. Stamford, Kallol Basu, Scott Edmondson, Zhiqiang Guo, William B. Geiss
  • SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20150274664
    Abstract: Substituted cyclopropyl piperidinyl compounds and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: September 25, 2013
    Publication date: October 1, 2015
    Applicant: Marck Sharp & Dohme Corp.
    Inventors: John J. Acton, Scott D. Edmondson, Ping Liu, Michael W. Miller, Harold B. Wood, Byron G. DuBois, William B. Geiss
  • Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
    Patent number: 8957062
    Abstract: Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: February 17, 2015
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Scott Edmondson, Zhiqiang Guo, Harold B. Wood, Andrew W. Stamford, Michael W. Miller, Duane E. DeMong, Gregori J. Morriello, Rajan Anand, Vincent J. Colandrea, Megan Macala, Milana Maletic, Cheng Zhu, Yuping Zhu, Wanying Sun, Kake Zhao, Yong Huang, Joel M. Harris, Lehua Chang, Nam Fung Kar, Zhiyong Hu, Liping Wang, Bowei Wang, Ping Liu, Jason W. Szewczyk, William B. Geiss
  • SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20140256699
    Abstract: Substituted cyclopropyl compounds of the formula I and the pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included. Another aspect of the invention that is of interest relates to compounds of formula Ia.
    Type: Application
    Filed: September 24, 2012
    Publication date: September 11, 2014
    Inventors: Michael W. Miller, Andrew W. Stamford, Kallol Basu, Scott Edmondson, Zhiqiang Guo, William B. Geiss
  • SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20140057893
    Abstract: Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119.
    Type: Application
    Filed: April 5, 2012
    Publication date: February 27, 2014
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Scott Edmondson, Zhiqiang Guo, Harold B. Wood, Andrew W. Stamford, Michael W. Miller, Duane E. DeMong, Gregori J. Morriello, Rajan Anand, Vincent J. Colandrea, Megan Macala, Milana Maletic, Cheng Zhu, Yuping Zhu, Wanying Sun, Kake Zhao, Yong Huang, Joel M. Harris, Lehua Chang, Nam Fung Kar, Zhiyong Hu, Liping Wang, Bowei Wang, Ping Liu, Jason W. Szewczyk, William B. Geiss
  • Polycyclic guanine derivatives and use thereof
    Patent number: 8349858
    Abstract: The present invention relates to Polycyclic Guanine Derivatives, compositions comprising the Polycyclic Guanine Derivatives and methods of using the Polycyclic Guanine Derivatives to treat pain or an inflammatory disease.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: January 8, 2013
    Assignee: Merck Sharp & Dohme
    Inventors: Deen Tulshian, William B. Geiss, Gregory S. Martin, Van-Duc Le, James C. Haber, Jr., Julius J. Matasi, Michael F. Czarniecki, Stephanie Nicole Cooke
  • Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof
    Publication number: 20110245238
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
    Type: Application
    Filed: June 17, 2011
    Publication date: October 6, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Manzer Durrani, William B. Geiss, David J. Fairfax, Dmytro O. Tymoshenko, Van-Duc Le, Lisa H. Peterson
  • POLYCYCLIC GUANINE DERIVATIVES AND USE THEREOF
    Publication number: 20110065738
    Abstract: The present invention relates to Polycyclic Guanine Derivatives, compositions comprising the Polycyclic Guanine Derivatives and methods of using the Polycyclic Guanine Derivatives to treat pain or an inflammatory disease.
    Type: Application
    Filed: June 18, 2008
    Publication date: March 17, 2011
    Inventors: Deen Tulshian, William B. Geiss, Gregory S. Martin, Van-Duc Le, James C. Haber, JR., Julius J. Matasi, Michael F. Czarniecki, Stephanie Nicole Cooke
  • Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof
    Publication number: 20110009393
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
    Type: Application
    Filed: July 19, 2010
    Publication date: January 13, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Manzer Durrani, William B. Geiss, David J. Fairfax, Dmytro O. Tymoshenko, Van-Duc Le, Lisa H. Peterson
  • Rifamycin analogs and uses thereof
    Publication number: 20100273765
    Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, 4?- and/or 6? halo and/or alkoxy analogs, and various 5? substituents that incorporate a cyclic amine moiety.
    Type: Application
    Filed: June 21, 2007
    Publication date: October 28, 2010
    Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Joseph Raker, Xiang Y. Yu, James M. Siedlecki, Yingfei Yang
  • Soluble 1,4 benzodiazepine compounds and stable salts thereof
    Patent number: 7759338
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: July 20, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Manzer Durrani, William B. Geiss, David J. Fairfax, Dmytro O. Tymoshenko, Van-Duc Le, Lisa Helen Peterson
  • Rifamycin analogs and uses thereof
    Patent number: 7547692
    Abstract: The present invention features rifamycin analogs and methods of using these compounds to treat a variety of microbial infections.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: June 16, 2009
    Assignee: ActivBiotics Pharma, LLC
    Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Joseph Raker, Xiang Y. Yu, James M. Siedlecki, Yingfei Yang
  • Rifamycin analogs and uses thereof
    Patent number: 7494991
    Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, and/or various fused ring systems with the benzene ring at the 4?,5? or 5?,6? positions.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: February 24, 2009
    Assignee: ActivBiotics Pharma, LLC
    Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Xiang Y. Yu, James M. Siedlecki, Yingfei Yang
  • Rifamycin analogs and uses thereof
    Patent number: 7342011
    Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, 4?- and/or 6? halo and/or alkoxy analogs, and various 5? substituents that incorporate a cyclic amine moiety.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: March 11, 2008
    Assignee: ActivBiotics, Inc.
    Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Joseph Raker
  • Rifamycin analogs and uses thereof
    Patent number: 7271165
    Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, 4?- and/or 6? halo and/or alkoxy analogs, and various 5? substituents that incorporate a cyclic amine moiety.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: September 18, 2007
    Assignee: ActivBiotics, Inc.
    Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Joseph Raker, Xiang Y. Yu, James M. Siedlecki, Yingfei Yang
  • Rifamycin analogs and uses thereof
    Patent number: 7220738
    Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, and/or various fused ring systems with the benzene ring at the 4?,5? or 5?,6? positions.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: May 22, 2007
    Assignee: ActivBiotics, Inc.
    Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Xiang Y. Yu, James M. Siedlecki, Yingfei Yang
  • Sulfhydryl rifamycins and uses thereof
    Patent number: 7078399
    Abstract: The invention features sulfhydryl rifamycin compositions, methods of making these compositions, and methods for treating disease using these compositions.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: July 18, 2006
    Assignee: ActivBiotics, Inc.
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Barry Eisenstein, William B. Geiss, Joseph Raker
  • Sulfhydryl rifamycins and uses thereof
    Publication number: 20040014749
    Abstract: The invention features sulfhydryl rifamycin compositions, methods of making these compositions, and methods for treating disease using these compositions.
    Type: Application
    Filed: December 12, 2002
    Publication date: January 22, 2004
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Barry Eisenstein, William B. Geiss, Joseph Raker
  • Method for making 24(S)-hydroxyvitamin D2
    Patent number: 6359012
    Abstract: The invention provides a method for making 24(S)-hydroxyvitamin D2 which is a stereospecific synthesis.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: March 19, 2002
    Assignee: Bone Care International, Inc.
    Inventors: Harold Meckler, Mark A. Helle, William B. Geiss, Brian T. Gregg