Patents by Inventor William B. Isaacs

William B. Isaacs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH PROSTATE CANCER RISK
    Publication number: 20090226912
    Abstract: The present invention provides a method of identifying a subject as having an increased risk of developing prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of developing prostate cancer.
    Type: Application
    Filed: December 19, 2008
    Publication date: September 10, 2009
    Inventors: Jianfeng Xu, S. Lilly Zheng, Henrik Gronberg, William B. Isaacs
  • Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
    Patent number: 7579147
    Abstract: The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: August 25, 2009
    Assignee: Wake Forest University Health Sciences
    Inventors: Jianfeng Xu, Deborah Meyers, Sigun Zheng, Patrick C. Walsh, William B. Isaacs, Eugene Bleecker, David Herrington
  • PCA3, PCA3 genes, and methods of use
    Patent number: 7008765
    Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: March 7, 2006
    Assignees: The Johns Hopkins University, Stichting Katholieke Universiteit more particularly The University Medical Centre
    Inventors: Marion J. G. Bussemakers, William B. Isaacs
  • Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
    Publication number: 20040018521
    Abstract: The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.
    Type: Application
    Filed: April 30, 2003
    Publication date: January 29, 2004
    Inventors: Jianfeng Xu, Deborah Meyers, Sigun Zheng, Patrick C. Walsh, William B. Isaacs, Eugene Bleecker, David Herrington
  • Prostate/colon tumor suppressor gene located on human chromosome 8
    Patent number: 6043088
    Abstract: This invention provides a novel nucleic acid molecule encoding a prostate/colon tumor suppressor gene product. The means and methods for detecting mutations and/or loss of prostate/colon tumor suppressor gene are provided. Also included within the scope of this invention are methods of suppressing the neoplastic phenotype of cancer cells having a defect in the prostate/colon tumor suppressor gene product. The invention also includes the means and methods for treating the cancer by administering the prostate/colon tumor suppressor gene.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: March 28, 2000
    Assignees: Canji, Inc., Johns Hopkins University
    Inventors: Robert Bookstein, William B. Isaacs
  • Genetic diagnosis of prostate cancer
    Patent number: 5552277
    Abstract: A method for detecting and a method for treating a cell proliferative disorder associated with glutathione-S-transferase (GSTP1) expression is provided. The method includes direct detection of a hypermethylated GSTP1 promoter, or indirect detection of decreased GSTP1 mRNA or GSTP1 protein in a suspect tissue sample.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: September 3, 1996
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: William G. Nelson, William B. Isaacs, Wen-Hsiang Lee