Patents by Inventor William B. Stine

William B. Stine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostaglandin E2 binding proteins and uses thereof
    Patent number: 8624002
    Abstract: The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: January 7, 2014
    Assignee: AbbVie, Inc.
    Inventors: Jjijie Gu, Charles W. Hutchins, Rong-rong Zhu, Jianwei Shen, Maria C. Harris, Eileen Belanger, Anwar Murtaza, Edit Tarcsa, William B. Stine, Chung-ming Hsieh
  • ANTI-NERVE GROWTH FACTOR (NGF) ANTIBODY COMPOSITIONS
    Publication number: 20110256135
    Abstract: The present invention relates to stable compositions of anti-NGF antibodies, and antigen-binding fragments thereof, and their uses in the prevention and/or treatment of various diseases and disorders in which NGF activity is detrimental, e.g., pain disorders.
    Type: Application
    Filed: March 16, 2011
    Publication date: October 20, 2011
    Inventors: Wolfgang FRAUNHOFER, Ravi Chari, Vineet Kumar, Rainer Saedler, Michael Siedler, William B. Stine, Carsten Weber
  • Prostaglandin E2 Binding Proteins and Uses Thereof
    Publication number: 20100040537
    Abstract: The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.
    Type: Application
    Filed: July 8, 2009
    Publication date: February 18, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Jjijie Gu, Charles W. Hutchins, Rong-rong Zhu, Jianwei Shen, Maria C. Harris, Eileen Belanger, Anwar Murtaza, Edit Tarcsa, William B. Stine, Chung-ming Hsieh
  • Method for improved decomposition of metal nitrate solutions
    Patent number: 4409157
    Abstract: A method for co-conversion of aqueous solutions of one or more heavy metal nitrates wherein thermal decomposition within a temperature range of about 300.degree. to 800.degree. C. is carried out in the presence of about 50 to 500% molar concentration of ammonium nitrate to total metal.
    Type: Grant
    Filed: January 21, 1981
    Date of Patent: October 11, 1983
    Inventors: Paul A. Haas, William B. Stines