Patents by Inventor William B. Wright, Jr.

William B. Wright, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Esters of (triarylphosphoranylidene)carbamic acid for effecting diuresis
    Patent number: 4892885
    Abstract: This disclosure describes novel esters of (triarylphosphoranylidene)carbamic acid which are useful as diuretic agents.
    Type: Grant
    Filed: April 19, 1988
    Date of Patent: January 9, 1990
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Walter E. Meyer
  • 2-heteroaryl-alkyl-1H-benz[de]-isoquinoline-1,3(2H)-diones
    Patent number: 4782064
    Abstract: This invention concerns novel 2-heteroarylalkyl-1H-benz[de]isoquinoline-1,3(2H)-diones which are useful as inhibitors of thromboxane synthetase and/or as hypotensive agents in the treatment of hypertension and myocardial ischemia.
    Type: Grant
    Filed: July 21, 1986
    Date of Patent: November 1, 1988
    Assignee: American Cyanamid Co.
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik, Nancy H. Eudy
  • Pharmaceutical methods of using 3-heteroarylalkyl-4-quinazolinones
    Patent number: 4753944
    Abstract: Novel 3-heteroarylalkyl-4-quinazolinones which are useful as inhibitors of thromboxane synthetase and/or as antihypertensive agents in the treatment of hypertension and myocardial ischemia.
    Type: Grant
    Filed: September 28, 1987
    Date of Patent: June 28, 1988
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik
  • N-[.omega.(3-pyridinyl)alkyl]benzamides, useful as thromboxane synthetase enzyme and/or cardioprotective agents
    Patent number: 4743610
    Abstract: N-[.omega.(3-pyridinyl)alkyl]benzamides which are useful as inhibitors of thromboxane synthetase enzyme and/or as cardioprotective agents in the prevention of myocardial infarction.
    Type: Grant
    Filed: March 16, 1987
    Date of Patent: May 10, 1988
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik
  • 3-heteroarylalkyl-4-quinazolinones
    Patent number: 4710502
    Abstract: Novel 3-heteroarylalkyl-4-quinazolinones which are useful as inhibitors of thromboxane synthetase and/or as antihypertensive agents in the treatment of hypertension and myocardial ischemia.
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: December 1, 1987
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik
  • 3-heteroalkyl-2,4-quinzaolinediones
    Patent number: 4684654
    Abstract: Compounds of the formula: ##STR1## wherein A is a divalent moiety of the formula:--C.sub.n H.sub.2n -- --CH.sub.2 CH.dbd.CHCH.sub.2 --or ##STR2## wherein n is an integer from 2-10, inclusive; R is hydrogen or alkyl having from one to four carbon atoms; R.sub.1 and R.sub.2 may be the same or different and may be selected from the group consisting of hydrogen, halogen, trifluoromethyl, alkoxy having from one to four carbon atoms, alkyl having from one to four carbon atoms, nitro and amino; wherein Heteroaryl is ##STR3## wherein R.sub.3 and R.sub.4 may be selected from hydrogen, alkyl having from one to four carbon atoms, or phenyl; and X is CH or N, together with the pharmaceutically acceptable salts thereof, which act as thromboxane synthetase inhibitors and hypotensive agents; methods for their production and use.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: August 4, 1987
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik
  • 3-imidazolylalkyl-, triazolylalkyl-, pyridinylalkyl-1,2,3-benzotriazin-4(3H)-ones and derivatives thereof
    Patent number: 4680293
    Abstract: Novel 3-heteroarylalkyl-1,2,3-benzotriazin-4(3H)-ones, having the structural formula: ##STR1## wherein A is a divalent moiety of the formula: ##STR2## wherein n is an integer from 3 to 10, inclusive; R.sub.1 and R.sub.2 may be the same or different and may be selected from the group consisting of hydrogen, halogen, trifluoromethyl, alkoxy having from one to four carbon atoms, alkyl having from one to four carbon atoms, nitro and amino; wherein Heteroaryl is ##STR3## wherein R.sub.3 and R.sub.4 may be hydrogen, alkyl having from one to four carbon atoms or phenyl and X is CH or N; together with the pharmaceutically acceptable salts thereof; processes for their preparation and their use in treating prostaglandin-related vascular disorders including ischemic heart disease, transient ischemic attack, thrombosis, migraine and hypertension.
    Type: Grant
    Filed: March 3, 1986
    Date of Patent: July 14, 1987
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • N-[(1H-imidazol-1-yl)alkyl]-1H-indolecarboxamides useful as thromboxane synthetase inhibitors and antihypertensive agents
    Patent number: 4619941
    Abstract: This invention discloses novel N-[(1H-imidazol-1-yl)alkyl]-1H-indolecarboxamides which are useful as inhibitors of thromboxane synthetase and/or as antihypertensive agents in the treatment of hypertension and myocardial ischemia.
    Type: Grant
    Filed: November 19, 1984
    Date of Patent: October 28, 1986
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Jeffery B. Press
  • N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)-alkyl]benzenesulfonamides and thromboxane synthetase/antihypertensive compositions
    Patent number: 4610981
    Abstract: This invention concerns novel N-[(1H-imidazol-1-yl), (1H-1,2,4-triazol-1-yl) and (3-pyridyl)alkyl]benzenesulfonamides which are useful as inhibitors of thromboxane synthetase enzyme and/or as antihypertensive agents.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: September 9, 1986
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Marsico, Jr., William B. Wright, Jr.
  • N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas
    Patent number: 4576957
    Abstract: N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas which are inhibitors of thromboxane synthetase enzyme.
    Type: Grant
    Filed: July 5, 1984
    Date of Patent: March 18, 1986
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Marsico, Jr., William B. Wright, Jr., Jeffery B. Press
  • N-[(1H-1,2,4-Triazol-1-yl)alkyl]-arylamides
    Patent number: 4568685
    Abstract: N-[(1H-1,2,4-Triazol-l-yl)alkyl]arylamides which are inhibitors of thromboxane synthetase enzyme.
    Type: Grant
    Filed: February 29, 1984
    Date of Patent: February 4, 1986
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Jeffery B. Press, Andrew S. Tomcufcik
  • N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
    Patent number: 4568687
    Abstract: This disclosure describes novel N-[.omega.-(1H-imidazol-1-yl)alkyl]arylamides which possess the property of inhibiting the enzyme thromboxane synthetase and are also useful in the treatment of hypertension and myocardial ischemia.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: February 4, 1986
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Jeffrey B. Press
  • Thromboxane synthetase enzyme inhibiting N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides
    Patent number: 4555519
    Abstract: This invention concerns novel N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides which are useful as inhibitors of thromboxane synthetase and/or as hypotensive agents in the treatment of hypertension and myocardial ischemia.
    Type: Grant
    Filed: November 19, 1984
    Date of Patent: November 26, 1985
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Jeffery B. Press
  • Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides
    Patent number: 4542145
    Abstract: Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides are inhibitors of thromboxane synthetase enzyme.
    Type: Grant
    Filed: February 29, 1984
    Date of Patent: September 17, 1985
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Jeffery B. Press, Andrew S. Tomcufcik
  • Substituted N-[.omega.-(1H-imidazol-1-yl)alkyl]-amides
    Patent number: 4489089
    Abstract: This disclosure describes novel N-[.omega.-(1H-imidazol-1-yl)alkyl]amides which possess the property of inhibiting the enzyme thromboxane synthetase.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: December 18, 1984
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Jeffrey B. Press
  • 3-[(.alpha.-Substituted-benzyl]-2,3,dihydr othiazolo[3,2-a][1,3]diazacyclan-3-ol derivatives
    Patent number: 4393004
    Abstract: This disclosure describes certain novel 3-(.alpha.-substituted-benzyl)-2,3-dihydrothiazolo[3,2-a][1,3]diazacyclan- 3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: January 29, 1982
    Date of Patent: July 12, 1983
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • Substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols
    Patent number: 4377589
    Abstract: This disclosure describes substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols which are useful as diuretic agents.
    Type: Grant
    Filed: April 9, 1981
    Date of Patent: March 22, 1983
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • 2,3-Disubstituted-thiazolo[3,2-a]pyrimidines
    Patent number: 4347248
    Abstract: This disclosure describes 2,3-disubstituted-thiazolo[3,2-a]pyrimidines which are useful as diuretic agents.
    Type: Grant
    Filed: March 23, 1981
    Date of Patent: August 31, 1982
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • 2,3-Disubstituted-2,3,5,6,7,8-hex ahydro-thiazolo[3,2-a]-[1,3]diazepin-3-ols
    Patent number: 4344954
    Abstract: This disclosure describes certain novel 2,3-disubstituted-2,3,5,6,7,8-hexahydro-thiazolo[3,2-][1,3]diazepin-3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: July 9, 1980
    Date of Patent: August 17, 1982
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • .omega.-Heteroaroyl(propionyl or butyryl)-L-prolines
    Patent number: 4342691
    Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright