Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: Endovascular stents and grafts for repairing portions of anatomical vessels are provided. The stent grafts may be attached to a graft positionable at a junction where a vessel divides or branches with at least one other vessel for repair of an aneurysm in the region of the junction.

Abstract: A sleeve for holding an endoscope used in surgical procedures including a hollow cylinder for receiving the endoscope, a docking member at the proximal end of the cylinder for receiving the viewing hub of the endoscope, a continuous suction supply adjacent the distal end of the cylinder, and a pressurized fluid supply for use when needed to clean the window of the endoscope.

Abstract: A sleeve for holding an endoscope used in surgical procedures comprising a hollow cylinder for receiving the outer tube of an endoscope with a viewing hub at its proximal end and a window at its distal end, a docking member at the proximal end of the cylinder to receive and retain the viewing hub, means for continuously supplying suction to an inlet adjacent the distal end of the cylinder, and means for supplying pressurized fluid when desired to an outlet adjacent the distal end of the cylinder.

Abstract: A disposable feed and water dispenser comprises a recycleable PET container with a threaded neck and a recycleable tray suspended from the container. The tray has a roof with a hole therethrough that mates with the container neck threads and a platform parallel to and spaced below the roof. Seed flowing out the container neck is collected in a mound on the platform. The mound size is controlled by changing the distance between the end of the container neck and the tray platform, which is achieved by adjusting the amount of engagement of the container threads with the tray roof. The tray may be fabricated from a flat cruciform shaped blank of recyclable polyvinylchloride that is approximately folded into the tray or that is thermoformed to the desired size and configuration. The disposable feed and water dispenser may be hung from an overhead member by a pair of strips, one end of each of which is bent over 180 degrees and inserted between the container and a cup loosely fastened to the container.