Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.

Abstract: Systems and techniques that facilitate scalable thermal energy recycling for cryogenic systems are provided. In various embodiments, a system can comprise at least one cryostat. In various aspects, the system can further comprise a thermal battery coupled to the at least one cryostat by a thermal exchange system. In various instances, the thermal battery can be configured to store thermal energy extracted from the at least one cryostat or to supply thermal energy to the at least one cryostat.

Abstract: A process of mass transfer is described which utilises latent heat transfer with little or sensible heat transfer. In a preferred process microbubbles are used under certain conditions of contact with a liquid phase to ensure highly effective mass transfer between a gaseous and liquid phase with significantly less than expected or little or no sensible heat transfer. The present invention in part provides a means by which the known state of a cold liquid of varying depths can be changed using a hot gas injected via a micro bubble inducing internal mixing without allowing the resultant mixture to reach equilibrium thereby ensuring the transfer process becomes continuous. Thus a process is described wherein at least one gaseous phase is contacted with at least one liquid phase such that the heat ratio of the system (AA) is maintained at an a value of greater than 0.5, and the mass transfer is effected by passing a gaseous phase comprising microbubbles through a liquid phase of thickness no more than 10 cm.

Abstract: A fluidic oscillator includes at least one inlet port (57) in communication with at least two outlets (61) via a nozzle region and two outlet conduits (58, 62), the two outlet conduits being separated from each other by a splitter region. Each outlet conduit includes a resonance chamber (60) in fluid communication with the conduit. The resonance chambers contribute to controlling the oscillation of the device. The fluidic oscillator is operatable in an acoustic switching mode.

Abstract: The present invention relates to pharmaceutical compositions of an non-steroidal anti-inflammatory drug (NSAIDs) such as, aspirin, diclofenac, ibuprofen, ketoprofen, or naproxen, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The compositions, which can be formulated for topical administration, can provide extended release of the NSAIDs. The compositions of the invention are useful, for example, in the prophylactic treatment or treatment and/or reduction of pain, in the prophylactic treatment or treatment of headaches such as migraine headaches and symptoms of migraine headaches, and in the treatment of temporomandibular disorders (TMD).

Abstract: The present invention relates to pharmaceutical compositions of a non-steroidal anti-inflammatory drug (NSAIDs) such as, aspirin, diclofenac, ibuprofen, ketoprofen, or naproxen, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The compositions, which can be formulated for topical administration, can provide extended release of the NSAIDs. The compositions of the invention are useful, for example, in the prophylactic treatment or treatment and/or reduction of pain, in the prophylactic treatment or treatment of headaches such as migraine headaches and symptoms of migraine headaches, and in the treatment of temporomandibular disorders (TMD).

Abstract: A cargo management system includes a cargo anchor including a body extending between first and second ends and defining a hook profile along a first plane perpendicular to an axis extending between the first and second ends and a closed loop profile along a second plane parallel to the axis. The system further includes a substrate having an attachment feature with a first portion coupleable with the anchor profile and a second portion coupleable with the loop profile.

Abstract: Uses of a method of producing small bubbles of gas in a liquid include gas transfer in airlift bioreactors and anaerobic digesters, and particle separation. The method uses a source of the gas under pressure, a conduit opening into a liquid and oscillating the gas passing along the conduit. The oscillation is effected by fluidic oscillator, comprising a diverter that divides the supply into respect outputs, each output being controlled by a control port, wherein the control ports are interconnected by a closed loop. Separation of algae from water involves delivering a laminar flow of microbubbles in the range 10 to 100 ?m diameter. Such bubbles also deliver a laminar flow in bioreactors that delivers enhanced liquid flow despite the small bubbles, which improves mixing and also enhances efficiency of gas exchange and retention of the bubbles in the reactor.

Abstract: The present invention relates to pharmaceutical compositions of a non-steroidal anti-inflammatory drug (NSAIDs) such as, aspirin, diclofenac, ibuprofen, ketoprofen, or naproxen, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The compositions, which can be formulated for topical administration, can provide extended release of the NSAIDs. The compositions of the invention are useful, for example, in the prophylactic treatment or treatment and/or reduction of pain, in the prophylactic treatment or treatment of headaches such as migraine headaches and symptoms of migraine headaches, and in the treatment of temporomandibular disorders (TMD).

Abstract: A method according to one embodiment includes combining an amorphous iron-based alloy and at least one metal selected from a group consisting of molybdenum, chromium, tungsten, boron, gadolinium, nickel phosphorous, yttrium, and alloys thereof to form a mixture, wherein the at least one metal is present in the mixture from about 5 atomic percent (at %) to about 55 at %; and ball milling the mixture at least until an amorphous alloy of the iron-based alloy and the at least one metal is formed. Several amorphous iron-based metal alloys are also presented, including corrosion-resistant amorphous iron-based metal alloys and radiation-shielding amorphous iron-based metal alloys.

Abstract: A process of mass transfer is described which utilises latent heat transfer with little or sensible heat transfer. In a preferred process microbubbles are used under certain conditions of contact with a liquid phase to ensure highly effective mass transfer between a gaseous and liquid phase with significantly less than expected or little or no sensible heat transfer. The present invention in part provides a means by which the known state of a cold liquid of varying depths can be changed using a hot gas injected via a micro bubble inducing internal mixing without allowing the resultant mixture to reach equilibrium thereby ensuring the transfer process becomes continuous. Thus a process is described wherein at least one gaseous phase is contacted with at least one liquid phase such that the heat ratio of the system (AA) is maintained at an a value of greater than 0.5, and the mass transfer is effected by passing a gaseous phase comprising microbubbles through a liquid phase of thickness no more than 10 cm.

Abstract: A process of mass transfer is described which utilizes latent heat transfer with little or sensible heat transfer. In a preferred process microbubbles are used under certain conditions of contact with a liquid phase to ensure highly effective mass transfer between a gaseous and liquid phase with significantly less than expected or little or no sensible heat transfer. The present invention in part provides a means by which the known state of a cold liquid of varying depths can be changed using a hot gas injected via a micro bubble inducing internal mixing without allowing the resultant mixture to reach equilibrium thereby ensuring the transfer process becomes continuous. Thus a process is described wherein at least one gaseous phase is contacted with at least one liquid phase such that the heat ratio of the system (AA) is maintained at an a value of greater than 0.5, and the mass transfer is effected by passing a gaseous phase comprising microbubbles through a liquid phase of thickness no more than 10 cm.

Abstract: Apparatus (200) for the treatment of one or more substrates comprising a treatment chamber configured to receive a liquid medium and one or more substrates; a supply of a treatment gas comprising ozone; and one or more conduits to convey said treatment gas to a bubble generator (41) wherein said bubble generator is operable to form bubbles of said treatment gas in said liquid medium, wherein the apparatus comprises a multiplicity of solid particles (46). A method of treating one or more substrates, the method comprising agitating said one or more substrates in a treatment formulation comprising a multiplicity of solid particles, a liquid medium and bubbles of ozone.

Abstract: The present invention relates to pharmaceutical compositions of an non-steroidal anti-inflammatory drug (NSAIDs) such as, aspirin, diclofenac, ibuprofen, ketoprofen, or naproxen, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The compositions, which can be formulated for topical administration, can provide extended release of the NSAIDs. The compositions of the invention are useful, for example, in the prophylactic treatment or treatment and/or reduction of pain, in the prophylactic treatment or treatment of headaches such as migraine headaches and symptoms of migraine headaches, and in the treatment of temporomandibular disorders (TMD).

Abstract: A cargo management system includes a cargo anchor including a body extending between first and second ends and defining a hook profile along a first plane perpendicular to an axis extending between the first and second ends and a closed loop profile along a second plane parallel to the axis.

Abstract: A cargo management system for a vehicle includes a first pair, a second pair, and a third pair of anchors. The first and second pairs of anchors are positioned adjacent each other and the third pair of anchors is positioned remote from the first pair. The system further includes a flexible substrate having a first pair of attachment features coupleable with the first pair of anchors and a second pair of attachment features selectively coupleable with the second pair or third pair of anchors.

Abstract: A method of manufacturing a handle intended to be gripped by an occupant of a vehicle is shown to comprise the steps of selecting a substrate including a first part and a second part. The first part and second part are wrapped with a covering material that may be a premium material such as leather and may also include a layer of foam padding. The first part and second part are assembled together and attached to each other. After the two parts are wrapped, the first part and second part are assembled together and attached to each other. A line of stitches may be formed on the covering material before the wrapping step that are wrapped to be visible on the handle.

Abstract: A method of manufacturing a handle intended to be gripped by an occupant of a vehicle is shown to comprise the steps of selecting a substrate including a first part and a second part. The first part and second part are wrapped with a covering material that may be a premium material such as leather and may also include a layer of foam padding. The first part and second part are assembled together and attached to each other. After the two parts are wrapped, the first part and second part are assembled together and attached to each other. A line of stitches may be formed on the covering material before the wrapping step that are wrapped to be visible on the handle.

Abstract: A seatbelt assembly includes an adjuster having a guide slidable in a first direction. The assembly also includes a cover defining upper and lower edges and coupled with the guide and first and second extension plates slidably disposed relative to the cover in the first direction so as to be extendable respectively from the upper and lower edges thereof and to be retractable behind the cover.

Abstract: A method according to one embodiment includes combining an amorphous iron-based alloy and at least one metal selected from a group consisting of molybdenum, chromium, tungsten, boron, gadolinium, nickel phosphorous, yttrium, and alloys thereof to form a mixture, wherein the at least one metal is present in the mixture from about 5 atomic percent (at %) to about 55 at %; and ball milling the mixture at least until an amorphous alloy of the iron-based alloy and the at least one metal is formed.