Abstract: The present invention provides organic nanoparticles that include a molecule having a Log P value of about 3 or above, an amphiphilic diblock copolymer or a surfactant, and a pharmaceutically-acceptable hydrophilic polymer. The present invention also provides methods of making these nanoparticles, e.g., by flash nanoprecipitation, with control over particle size and surface properties. The methods of the present invention provide a means for co-precipitating a water-insoluble compound with an amphiphilic stabilizer within a few milliseconds. The nanoparticles of the present invention exhibit high drug loading, e.g., 50% w/w, and can be produced with a mean particle size less than 200 nm and with a narrow particle size distribution.

Abstract: A chair has a supporting frame 1, a seat portion 101, a back portion 201 that has an upper end, a lower end, and is pivotally mounted relative to the supporting frame at a position above its lower end, and a recline mechanism 601. The recline mechanism 601 lifts the seat portion 101 upon a reclining action of the back portion 201, and has an operative connection 603, 611 between the seat portion and the supporting frame and a drag link 602 pivotally connected to the seat portion 101 and pivotally connected to the back portion 201 at a position below the pivotal mounting of the back portion relative to the supporting frame. As the back portion 201 of the chair is reclined, the lower end of the back portion 201 moves forward and the drag link 602 pulls the seat portion 101 upward relative to the supporting frame 1.

Abstract: A segmented track made of a plurality of elastomeric track segments is provided. Each track segment is made of reinforced elastomeric material and is provided, at each end thereof, with a joint element adapted to be connected to the joint element of adjacent track segments. Each track segment comprises longitudinally extending reinforcing elements which are embedded into the elastomeric material and which are extending between and coupled to both joint elements.

Abstract: A chair has a supporting frame 1, a seat portion 101, a back portion 201 that has an upper end, a lower end, and is pivotally mounted relative to the supporting frame at a position above its lower end, and a recline mechanism 601. The recline mechanism 601 lifts the seat portion 101 upon a reclining action of the back portion 201, and has an operative connection 603, 611 between the seat portion and the supporting frame and a drag link 602 pivotally connected to the seat portion 101 and pivotally connected to the back portion 201 at a position below the pivotal mounting of the back portion relative to the supporting frame. As the back portion 201 of the chair is reclined, the lower end of the back portion 201 moves forward and the drag link 602 pulls the seat portion 101 upward relative to the supporting frame 1.

Abstract: The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (MRI). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means for diagnosing Alzheimer's disease at an early stage.

Abstract: A chair has a supporting frame 1, a seat portion 101, a back portion 201 that has an upper end, a lower end, and is pivotally mounted relative to the supporting frame at a position above its lower end, and a recline mechanism 601. The recline mechanism 601 lifts the seat portion 101 upon a reclining action of the back portion 201, and has an operative connection 603, 611 between the seat portion and the supporting frame and a drag link 602 pivotally connected to the seat portion 101 and pivotally connected to the back portion 201 at a position below the pivotal mounting of the back portion relative to the supporting frame. As the back portion 201 of the chair is reclined, the lower end of the back portion 201 moves forward and the drag link 602 pulls the seat portion 101 upward relative to the supporting frame 1.

Abstract: A chair has a seat support, a seat portion, a back portion, and a supporting frame. The supporting frame is formed by a castored base, a height adjustment mechanism, and a main transom. The seat portion is selectively moveable relative to the supporting frame, with the seat portion having a locked configuration and a released configuration. The back portion has a back frame and a compliant cover. The back frame has hood features for receiving a portion of the compliant cover. The back portion is reclinable relative to the supporting frame between an upright position and a reclined position. A recline mechanism has deformable members operatively connecting the seat portion and the supporting frame. A recline resistance mechanism is selectively engageable to resist movement of the back portion toward the reclined position.

Abstract: A segmented track made of a plurality of elastomeric track segments is provided. Each track segment is made of reinforced elastomeric material and is provided, at each end thereof, with a joint element adapted to be connected to the joint element of adjacent track segments. Each track segment comprises longitudinally extending reinforcing elements which are embedded into the elastomeric material and which are extending between and coupled to both joint elements.

Abstract: A segmented track made of a plurality of elastomeric track segments is provided. Each track segment is made of reinforced elastomeric material and is provided, at each end thereof, with a joint element adapted to be connected to the joint element of adjacent track segments. Each track segment comprises longitudinally extending reinforcing elements which are embedded into the elastomeric material and which are extending between and coupled to both joint elements.

Abstract: A chair has a seat support, a seat portion, a back portion, and a supporting frame. The supporting frame is formed by a castored base, a height adjustment mechanism, and a main transom. The seat portion is selectively moveable relative to the supporting frame, with the seat portion having a locked configuration and a released configuration. The back portion has a back frame and a compliant cover. The back frame has hood features for receiving a portion of the compliant cover. The back portion is reclinable relative to the supporting frame between an upright position and a reclined position. A recline mechanism has deformable members operatively connecting the seat portion and the supporting frame. A recline resistance mechanism is selectively engageable to resist movement of the back portion toward the reclined position.

Abstract: A chair has a seat support (101), a seat portion (13), a back portion (15), and a supporting frame. The supporting frame is formed by a castored base (11), a height adjustment mechanism (17), and a main transom (21). The seat portion (13) is selectively moveable relative to the supporting frame, with the seat portion having a locked configuration and a released configuration. The back portion has a back frame (25) and a compliant cover (61). The back frame has hook features for receiving a portion of the compliant cover (61). The back portion (15) is reclinable relative to the supporting frame between an upright position and a reclined position. A recline mechanism has deformable members operatively connecting the seat portion and the supporting frame. A recline resistance mechanism is selectively engageable to resist movement of the back portion toward the reclined position.

Abstract: A method of injection molding a polymeric resin to form an article that is suitable for strain orientation. A thermoplastic polyester elastomer polymeric resin is provided. The resin is heated to form a molten resin at a temperature of at least about 240° C. The molten resin is injected into a mold (22) to substantially fill the mold and form an article. At least part of the article is a sheet part with a plurality of members that are integrally formed into the sheet part, with apertures provided between at least some of the members of the sheet part of the article to form a mesh. At least the sheet part of the article is suitable for strain orientation.

Abstract: A chair has a supporting frame 1, a seat portion 101, a back portion 201 that has an upper end, a lower end, and is pivotally mounted relative to the supporting frame at a position above its lower end, and a recline mechanism 601. The recline mechanism 601 lifts the seat portion 101 upon a reclining action of the back portion 201, and has an operative connection 603, 611 between the seat portion and the supporting frame and a drag link 602 pivotally connected to the seat portion 101 and pivotally connected to the back portion 201 at a position below the pivotal mounting of the back portion relative to the supporting frame. As the back portion 201 of the chair is reclined, the lower end of the back portion 201 moves forward and the drag link 602 pulls the seat portion 101 upward relative to the supporting frame 1.

Abstract: A segmented track made of a plurality of elastomeric track segments is provided. Each track segment is made of reinforced elastomeric material and is provided, at each end thereof, with a joint element adapted to be connected to the joint element of adjacent track segments. Each track segment comprises longitudinally extending reinforcing elements which are embedded into the elastomeric material and which are extending between and coupled to both joint elements.

Abstract: A chair has a seat support (101), a seat portion (13), a back portion (15), and a supporting frame. The supporting frame is formed by a castored base (11), a height adjustment mechanism (17), and a main transom (21). The seat portion (13) is selectively moveable relative to the supporting frame, with the seat portion having a locked configuration and a released configuration. The back portion has a back frame (25) and a compliant cover (61). The back frame has hook features for receiving a portion of the compliant cover (61). The back portion (15) is reclinable relative to the supporting frame between an upright position and a reclined position. A recline mechanism has deformable members operatively connecting the seat portion and the supporting frame. A recline resistance mechanism is selectively engageable to resist movement of the back portion toward the reclined position.

Abstract: A method of injection moulding a polymeric resin to form an article that is suitable for strain orientation. A thermoplastic polyester elastomer polymeric resin is provided. The resin is heated to form a molten resin at a temperature of at least about 240° C. The molten resin is injected into a mould (22) to substantially fill the mould and form an article. At least part of the article is a sheet part with a plurality of members that are integrally formed into the sheet part, with apertures provided between at least some of the members of the sheet part of the article to form a mesh. At least the sheet part of the article is suitable for strain orientation.

Abstract: In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In one aspect, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.

Abstract: A feed shoe having at least one feed chamber with an open bottom portion and an open front portion whereat a gate is provided. The gate can be vertically adjustable and can have a lower edge defining a leading edge of the feed chamber, wherein the leading edge can have a flat, serrated, or rounded profile depending upon the type of feed material used. The gate, or a separate main gate adjacent the gate, can have a flat, curved, or V-shaped inner surface facing the feed chamber, wherein a lower portion of the inner surface can have a stepped profile which shears the material in the feed chamber in separate planes. The feed shoe can further include an attachment portion adapted for adjustably retaining an end of at least one material feed delivery member in communication with said at least one feed chamber.

Abstract: In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In one aspect, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.

Abstract: The invention relates to an imaging element comprising a pragmatic imaging sheet comprising paper having a resin coat on each side, adhesively adhered to a carrier sheet with a pressure-sensitive adhesive, comprising at least one core layer of polyester and a rough lower surface layer.