Abstract: Systems and methods for operation of a memory system are disclosed. In some example embodiments, a system for storing or retrieving data in response to one or more signals provided from one or more clients includes a plurality of memcached-type memory devices arranged in a cluster, and a proxy module configured to communicate at least indirectly with each of the memcached-type memory devices and further configured to receive the one or more signals. The proxy module is configured to perform a determination of how to proceed in communicating with the memcached-type memory devices for the purpose of the storing or retrieving of data at or from one or more of the memcached-type memory devices in response to the one or more signals. In additional example embodiments, the proxy module is a centralized proxy and makes selections among the memory devices based upon performing of a memcache selection/fail-over algorithm (MSFOA).