Patents by Inventor William Bourn
William Bourn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932847Abstract: Disclosed is a method of fragmenting DNA comprising contacting a sample of target DNA with (a) a composition comprising an active transpososome, and (b) a composition comprising an inactive transpososome, under conditions suitable for transpososome activity, wherein a ratio of an amount of the inactive transpososome in the composition of (b) to an amount of the active transpososome in the composition of (a) determines the mean fragment size and a level of insertion bias.Type: GrantFiled: April 19, 2017Date of Patent: March 19, 2024Assignee: KAPA BIOSYSTEMS, INC.Inventors: Martin Ranik, Eric Van der Walt, William Bourn, Jennifer Hsieh, Abre De Beer, Gerrida Uys, Paul McEwan
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Patent number: 11746339Abstract: The present invention provides improved DNA polymerases that may be better suited for applications in recombinant DNA technologies, in particular technologies involving plant-derived samples. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: GrantFiled: March 11, 2021Date of Patent: September 5, 2023Assignee: Kapa Biosystems, Inc.Inventors: Wolfgang Schafer, Paul J. McEwan, Eric van der Walt, John Foskett, William Bourn
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Publication number: 20230165545Abstract: An example portable radiography scanning system includes: a radiation detector configured to generate digital radiography images based on incident radiation; a radiation emitter configured to output the radiation; and a computing device configured to: receive the digital radiography images from the radiation detector; compensate one or more of the digital radiography images for variations in magnification of the digital radiography images; and store one or more compensated radiography images based on the magnification compensation and associated with physical location information.Type: ApplicationFiled: November 28, 2022Publication date: June 1, 2023Inventors: Jason William Bourn, Paul Benson, Joseph Ryan Lapinskas
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Patent number: 11603547Abstract: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: GrantFiled: February 22, 2021Date of Patent: March 14, 2023Assignee: Kapa Biosystems, Inc.Inventors: William Bourn, Maryke Appel, Gavin Rush, John Foskett, Paul J. McEwan
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Publication number: 20230034628Abstract: An example portable radiography scanning system includes: a radiation detector configured to generate a digital image based on incident radiation; a radiation emitter configured to output the radiation; a frame configured to hold at least one of the radiation emitter or the radiation detector such that the radiation emitter directs the radiation to the radiation detector; a first sensor configured to determine a first distance between the radiation detector and the radiation emitter; and a computing device configured to: determine a second distance between the radiation emitter and an interface between the radiation and the object; determine a magnification correction factor based on the first distance and the second distance; measure a size, in pixels, of a feature of the object in the digital image; and at least one of: calculate an actual size of the feature based on the magnification correction factor and the measured size of the feature, or determine whether the measured sized of the feature satisfies aType: ApplicationFiled: July 28, 2022Publication date: February 2, 2023Inventors: Paul Benson, Jason William Bourn
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Publication number: 20230034478Abstract: An example radiography scanning system includes: a radiation detector configured to generate digital images based on incident radiation; a radiation source configured to output the radiation toward the radiation detector; a thermal sensor configured to capture thermal images and having a field of view that at least partially overlaps a projection field of the radiation; and a computing device configured to: control the radiation source; receive the digital images from the radiation detector; receive the thermal images from the thermal camera; and output the digital images and the thermal images, in real-time, to a display device.Type: ApplicationFiled: July 28, 2022Publication date: February 2, 2023Inventors: Paul Benson, Jason William Bourn, Joseph Ryan Lapinskas
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Publication number: 20220121854Abstract: An example method to generate a video from multiple cameras including a digital X-ray imaging device involves: initiating a recording session on an X-ray digital imaging device; capturing one or more images using a first one of a plurality of imaging sensors of the X-ray digital imaging device; capturing one or more videos using a second one of the plurality of imaging sensors; storing, on a machine readable storage device, two or more files corresponding to the one or more images and the one or more videos captured using the first and second ones of the plurality of imaging sensors; and combining the two or more files into a single video file representative of the recording session.Type: ApplicationFiled: October 20, 2020Publication date: April 21, 2022Inventors: Jason William Bourn, Joseph Ryan Lapinskas, Paul Benson, Daniel J. Jozwiak
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Publication number: 20210317422Abstract: The present invention provides improved DNA polymerases that may be better suited for applications in recombinant DNA technologies, in particular technologies involving plant-derived samples. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: ApplicationFiled: March 11, 2021Publication date: October 14, 2021Inventors: Wolfgang Schafer, Paul J. McEwan, Eric van der Walt, John Foskett, William Bourn
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Publication number: 20210180102Abstract: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: ApplicationFiled: February 22, 2021Publication date: June 17, 2021Inventors: William Bourn, Maryke Appel, Gavin Rush, John Foskett, Paul J. McEwan
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Patent number: 10975361Abstract: The present invention provides improved DNA polymerases that may be better suited for applications in recombinant DNA technologies, in particular technologies involving plant-derived samples. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: GrantFiled: April 15, 2016Date of Patent: April 13, 2021Assignee: Kapa Biosystems, Inc.Inventors: Wolfgang Schafer, Paul McEwan, Eric Van Der Walt, John Foskett, William Bourn
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Patent number: 10961555Abstract: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: GrantFiled: May 3, 2018Date of Patent: March 30, 2021Assignee: Kapa Biosystems, Inc.Inventors: William Bourn, Maryke Appel, Gavin Rush, John Foskett, Paul J. McEwan
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Publication number: 20200347441Abstract: The disclosure provides compositions and methods for high-throughput screening a plurality of transposases to identify rare mutations that affect desired features of the transposase. Compositions of the disclosures are provided that facilitate the high-throughput screening methods of the disclosure.Type: ApplicationFiled: August 30, 2018Publication date: November 5, 2020Applicant: Kapa Biosystems, Inc.Inventors: Raeeza Allie, Michael Stuart Berry, William Bourn, Bjarne Faurholm, Suzanne Margaret Huddy, Martin Ranik, Du Toit Schabort
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Patent number: 10457968Abstract: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: GrantFiled: November 3, 2009Date of Patent: October 29, 2019Assignee: Kapa Biosystems, Inc.Inventors: William Bourn, Maryke Appel, Gavin Rush, John Foskett, Paul McEwan
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Publication number: 20190100783Abstract: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: ApplicationFiled: December 21, 2018Publication date: April 4, 2019Inventors: William Bourn, Maryke Appel, Gavin Rush, John Foskett, Paul J. McEwan
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Publication number: 20180195059Abstract: Disclosed is a method of fragmenting DNA comprising contacting a sample of target DNA with (a) a composition comprising an active transpososome, and (b) a composition comprising an inactive transpososome, under conditions suitable for transpososome activity, wherein a ratio of an amount of the inactive transpososome in the composition of (b) to an amount of the active transpososome in the composition of (a) determines the mean fragment size and a level of insertion bias.Type: ApplicationFiled: April 19, 2017Publication date: July 12, 2018Inventors: Martin RANIK, Eric VAN DER WALT, William BOURN, Jennifer HSIEH
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Publication number: 20170067037Abstract: The present invention provides improved DNA polymerases that may be better suited for applications in recombinant DNA technologies, in particular technologies involving plant-derived samples. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: ApplicationFiled: April 15, 2016Publication date: March 9, 2017Inventors: Wolfgang Schafer, Paul McEwan, Eric Van Der Walt, John Foskett, William Bourn
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Publication number: 20170051326Abstract: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: ApplicationFiled: September 22, 2016Publication date: February 23, 2017Inventors: William Bourn, Maryke Appel, Gavin Rush, John Foskett, Paul J. McEwan
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Patent number: 9388396Abstract: The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same. In some embodiments, the present invention can combine desired functional characteristics (e.g., high processivity; high elongation rate; thermostability; resistance to salt, PCR additives (e.g., PCR enhancers) and other impurities; and high fidelity) of different DNA polymerases in a chimeric polymerase.Type: GrantFiled: May 5, 2014Date of Patent: July 12, 2016Assignee: Kapa Biosystems, Inc.Inventors: Bjarne Faurholm, Paul McEwan, William Bourn, Gavin Rush
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Patent number: 9315787Abstract: The present invention provides improved DNA polymerases that may be better suited for applications in recombinant DNA technologies, in particular technologies involving plant-derived samples. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.Type: GrantFiled: January 13, 2012Date of Patent: April 19, 2016Assignee: KAPA BIOSYSTEMS, INC.Inventors: Wolfgang Schafer, Paul McEwan, Eric Van Der Walt, John Foskett, William Bourn
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Patent number: 9023633Abstract: The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same. In some embodiments, the present invention can combine desired functional characteristics (e.g., high processivity; high elongation rate; thermostability; resistance to salt, PCR additives (e.g., PCR enhancers) and other impurities; and high fidelity) of different DNA polymerases in a chimeric polymerase.Type: GrantFiled: November 3, 2009Date of Patent: May 5, 2015Assignee: Kapa BiosystemsInventors: Bjarne Faurholm, Paul McEwan, William Bourn, Gavin Rush