Abstract: An anti-IL-22 antibody or antibody fragment that binds to both human IL-22 and a mammalian IL-22 as well as modified anti-IL-22 antibodies and antibody fragments. Pharmaceutical compositions and kits comprising the antibody or antibody fragment are also provided. Also provided are methods for treatment of various IL-22 mediated conditions and diseases.

Abstract: An immersed membrane cassette has a high tank intensity achieved by one or more of: reduced module to module gap; using structural hollow tubing in at least parts of a frame in place of separate permeate and/or air pipes; and, using vertical permeate port connections. The cassette has a tank intensity over 650 m2/m2. The cassette may be combined with a fine screen. This specification also describes an immersed membrane module having a permeate port and/or connector on the top of a header. The permeate connection between the module and a permeate collection tube may be vertical, i.e. perpendicular to the length of the header. A piston seal may be used between the permeate port of the header and the permeate collection tube. The permeate collection tube may be a horizontal structural member on the periphery of a frame that holds the module.

Abstract: An anti-IL-22 antibody or antibody fragment that binds to both human IL-22 and a mammalian IL-22 as well as modified anti-IL-22 antibodies and antibody fragments. Pharmaceutical compositions and kits comprising the antibody or antibody fragment are also provided. Also provided are methods for treatment of various IL-22 mediated conditions and diseases.

Abstract: A laser spectrometer can be operated for analysis of one or more analytes present in a combustible gas mixture. The spectrometer can include one or more features that enable intrinsically safe operation. In other words, electrical, electronic, thermal, and/or optical energy sources can be limited within an hazardous are of the spectrometer where it is possible for an explosive gas mixture to exist. Methods, systems, articles and the like are described.

Abstract: An anti-IL-22 antibody or antibody fragment that binds to both human IL-22 and a mammalian IL-22 as well as modified anti-IL-22 antibodies and antibody fragments. Pharmaceutical compositions and kits comprising the antibody or antibody fragment are also provided. Also provided are methods for treatment of various IL-22 mediated conditions and diseases.

Abstract: A manufacturing execution system (MES) that provides tools for modeling and determining information about physical production lines made up of arrangements of entities. The MES includes configuration tools for modeling the entities in a physical production line. The MES also includes configuration tools for modeling the physical production line. Entity data models and line data models conform to the data structure of respective model templates. Line data models include line definition models and line layout models. Line layout models include an entity link model for each of the entities in the physical production line. The MES includes tools for dynamically determining the bottleneck for the physical production line. Other production metrics are also calculated using the MES.

Abstract: Anti-CD22 antibodies, including isolated nucleic acids that encode at least one such anti-CD22 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract: Anti-CD22 antibodies, including isolated nucleic acids that encode at least one such anti-CD22 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract: A manufacturing execution system (MES) that provides tools for modeling and determining information about physical production lines made up of arrangements of entities. The MES includes configuration tools for modeling the entities in a physical production line. The MES also includes configuration tools for modeling the physical production line. Entity data models and line data models conform to the data structure of respective model templates. Line data models include line definition models and line layout models. Line layout models include an entity link model for each of the entities in the physical production line. The MES includes tools for dynamically determining the bottleneck for the physical production line. Other production metrics are also calculated using the MES.

Abstract: A manufacturing execution system (MES) that provides tools for modeling and determining information about physical production lines made up of arrangements of entities. The MES includes configuration tools for modeling the entities in a physical production line. The MES also includes configuration tools for modeling the physical production line. Entity data models and line data models conform to the data structure of respective model templates. Line data models include line definition models and line layout models. Line layout models include an entity link model for each of the entities in the physical production line. The MES includes tools for dynamically determining the bottleneck for the physical production line. Other production metrics are also calculated using the MES.

Abstract: A laser spectrometer can be operated for analysis of one or more analytes present in a combustible gas mixture. The spectrometer can include one or more features that enable intrinsically safe operation. In other words, electrical, electronic, thermal, and/or optical energy sources can be limited within an hazardous are of the spectrometer where it is possible for an explosive gas mixture to exist. Methods, systems, articles and the like are described.

Abstract: Provide herein are methods for treating osteopenia with geranylgeranyl acetone (GGA) and derivatives thereof and compositions useful for the same.

Abstract: A manufacturing execution system (MES) that provides tools for modeling and determining information about physical production lines made up of arrangements of entities. The MES includes configuration tools for modeling the entities in a physical production line. The MES also includes configuration tools for modeling the physical production line. Entity data models and line data models conform to the data structure of respective model templates. Line data models include line definition models and line layout models. Line layout models include an entity link model for each of the entities in the physical production line. The MES includes tools for dynamically determining the bottleneck for the physical production line. Other production metrics are also calculated using the MES.

Abstract: Anti-CD22 antibodies, including isolated nucleic acids that encode at least one such anti-CD22 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof including therapeutic compositions, methods and devices.

Abstract: This invention relates generally to polyisoprenyl phosphonate derivatives pharmaceutical compositions comprising polyisoprenyl phosphonate derivatives, and uses thereof.

Abstract: Provide herein are methods for treating osteopenia with geranylgeranyl acetone (GGA) and derivatives thereof and compositions useful for the same.

Abstract: A sludge removal system for removing sludge from a clarifier tank is disclosed. The system comprises a movable sludge intake manifold, a stationary sludge outlet conduit and one or more conduits dynamically and fluidically connecting the manifold and the sludge outlet conduit, even as the manifold moves relative to the stationary sludge outlet. One or more of the conduits between the manifold and the outlet are connected in the system through rotatable conduit connectors which is part of the dynamic connection mentioned above. Improved sludge intake constructions are also disclosed.

Abstract: The invention provides specific binding members (e.g., antibodies or antigen-binding fragments thereof) which bind to RANKL originating from multiple species. An epitope recognized by the specific binding members can be selected from surface exposed loop domains that bind to and activate its cognate receptor, RANK (Receptor Activator of NFkB), on the surface of osteoclast precursors and other cell types. The invention provides peptides for generating such anti-RANKL antibodies, including murine sequences, other non-human sequences and cross-reactive peptides. The specific binding members are useful in the diagnosis and treatment of lytic bone diseases, including osteoporosis, rheumatoid arthritis, bone metastasis and hypercalcemia of malignancy, glucocorticoid-induced bone loss, a periodontal disease or condition, a cancer and Juvenile Paget's Disease.

Abstract: A self-expanding cage for use in conjunction with an embolic filtering device includes a circumferential member adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. A proximal strut and distal strut are attached to the circumferential member to form the cage. A plurality of proximal and distal struts may be attached the circumferential member. Additionally, a second circumferential member can be attached to the first circumferential member. Each circumferential member can be connected by a single or a plurality of connecting struts. One embodiment of the cage utilizes a single wire to form to the cage. A delivery system attached to the single wire cage moves the cage and its associated filter element between the expanded and unexpanded positions through relative movement of the distal delivery system.

Abstract: A catheter assembly configured for retrieval of medical devices from vasculature. The catheter includes an outer catheter and an inner catheter. The inner and/or outer catheter can include a tapered terminal end portion. A mandrel can be provided to facilitate advancement of the assembly within vasculature.