Abstract: The present disclosure provides DNA damage repair enzyme inhibitors and methods of treating or preventing a cancer in a subject by administering a DNA damage repair enzyme inhibitor to the subject.

Abstract: The present invention provides a hammer drill attachment for contacting external walls of formwork for imparting external vibration to concrete poured into the formwork, the attachment comprising: an input shaft configured to receive motion from an output of a hammer drill; an output shaft configured to contact the external walls of the formwork for imparting the external vibration, the output shaft being arranged transversely relative to the input shaft to output pulsed percussions in a transverse direction relative to a longitudinal axis of the output shaft, a connecting portion for connecting the output shaft with the input shaft to transmit motion from the input shaft to the output shaft when the input shaft is receiving motion from the output of the hammer drill. In another aspect of the present invention, there is provided a method for smoothing concrete contained within external walls of formwork.

Abstract: The present invention relates to polycyclic heterocyclic compounds and methods which may be useful as inhibitors of IGF-1R for the treatment or prevention of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO).

Abstract: The present invention relates to heterocyclic compounds, pharmaceutical compositions thereof, and methods which may be useful as inhibitors of IGF-1R for the treatment or prevention of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO).

Abstract: Provided is an optical element for a lithographic apparatus. The optical element includes a capping layer that includes oxygen vacancies therein. The oxygen vacancies prevent attack of the capping layer by preventing hydrogen and other species from penetrating the capping layer and underlying layers. The capping layer provides a low hydrogen recombination rate enabling hydrogen to clean the surface of the optical element. The capping layer may include an alloyed metal, a mixed metal oxide or a doped metal oxide and it may be a ruthenium capping layer that includes one or more dopants therein.

Abstract: A glass manufacturing apparatus including a forming apparatus, the forming apparatus including an edge separation assembly. The edge separation assembly includes a scoring device with a scoring tool coupled thereto, a backing roller, a pair of stabilizing rollers configured to pinch a central portion of the glass ribbon therebetween, and a separation roller configured to apply a separation force against an edge portion of the glass ribbon to separate the edge portion from the central portion. The edge separation apparatus may further include a first plurality of guide rollers arranged to direct the separated edge portion away from the central portion and a second plurality of guide rollers configured to guide the central portion. The forming apparatus further includes a cross-cut assembly configured to separate a glass sheet from the central portion.

Abstract: An optical source for a photolithography tool includes a source configured to emit a first beam of light and a second beam of light, the first beam of light having a first wavelength, and the second beam of light having a second wavelength, the first and second wavelengths being different; an amplifier configured to amplify the first beam of light and the second beam of light to produce, respectively, a first amplified light beam and a second amplified light beam; and an optical isolator between the source and the amplifier, the optical isolator including: a plurality of dichroic optical elements, and an optical modulator between two of the dichroic optical elements.

Abstract: Provided herein are compounds of Formula (I), Formula (II), Formula (III), a compound selected from any of the compounds in Table 1, Table 2, Table 3, Table 4 or a pharmaceutically acceptable salt or deuterated form thereof, wherein R1, R2, R3, R4, RD, RG, p and q are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of formula (I), or a compound selected from any of the compounds in Table 1, Table 2, Table 3, Table 4 or pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of formula (I), Formula (II), Formula (III), or pharmaceutically acceptable salt or deuterated form thereof, e.g., in treating 5-HT2A receptor associated diseases or disorders.

Abstract: Provided herein are compounds of Formula (I), a compound selected from any of the compounds in Table 1, Table 2, Table 3, or a pharmaceutically acceptable salt or deuterated form thereof, wherein R1, R2, R3 and R4 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of formula (I), or a compound selected from any of the compounds in Table 1, Table 2, Table 3, or pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of formula (I) or pharmaceutically acceptable salt or deuterated form thereof, e.g., in treating 5-HT2A receptor associated diseases or disorders.

Abstract: Disclosed herein are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, that are inhibitors of inhibitors of epidermal growth factor receptor (EGFR), including EGFR C797S mutants. Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Methods, compositions, and kits are provided for the detection of Influenza A in a test sample. The presence or absence of Influenza A in the sample is determined by nucleic acid based assays using primers and/or probes with excellent sensitivity, specificity and inclusivity for detecting Influenza A strains and/or subtypes Detection strategies may utilize loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.

Abstract: The present invention provides methods and system for power generation using a high efficiency combustor in combination with a CO2 circulating fluid. The methods and systems advantageously can make use of a low pressure ratio power turbine and an economizer heat exchanger in specific embodiments. Additional low grade heat from an external source can be used to provide part of an amount of heat needed for heating the recycle CO2 circulating fluid. Fuel derived CO2 can be captured and delivered at pipeline pressure. Other impurities can be captured.

Abstract: A method and apparatus for manufacturing a glass article includes flowing a glass ribbon through a housing having first and second side walls. The glass ribbon has first and second opposing major surfaces extending in a lengthwise and a widthwise direction. Ions are directed from an ionization source toward at least one of the first and second opposing major surfaces of the glass ribbon and/or an electrode directs particles away from at least one of the first and second opposing major surfaces of the glass ribbon. Such can reduce a density of particles on a major surface of the glass article formed from the glass ribbon.

Abstract: A method of finishing edges of glass sheets may include engaging an edge of a glass sheet with a groove of an edge finishing wheel as the edge finishing wheel is rotated with a motor. A working current of the motor may be monitored when the edge finishing wheel is engaged with the edge of the glass sheet. The working current may be indicative of a working torque of the motor. The method may further include determining if the working torque of the motor is greater than an upper threshold torque value corresponding to a maximum groove depth. A blade of a cutting head is engaged with an outer diameter of the edge finishing wheel when the working torque of the motor is greater than the upper threshold torque value thereby shaving material from the outer diameter of the edge finishing wheel and decreasing the working torque of the motor.

Abstract: Methods, compositions, and kits are provided for the detection of Influenza B in a test sample. The presence or absence of Influenza B in the sample is determined by nucleic acid based assays using primers and/or probes with excellent sensitivity, specificity, and inclusivity for Influenza B strains and/or subtypes. Detection strategies may utilize loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.

Abstract: The present invention provides methods and system for power generation using a high efficiency combustor in combination with a CO2 circulating fluid. The methods and systems advantageously can make use of a low pressure ratio power turbine and an economizer heat exchanger in specific embodiments. Additional low grade heat from an external source can be used to provide part of an amount of heat needed for heating the recycle CO2 circulating fluid. Fuel derived CO2 can be captured and delivered at pipeline pressure. Other impurities can be captured.

Abstract: Methods, systems, and computer programs are presented for generating a usage model for predicting user commands in an app. One method includes receiving model information from client devices. The model is obtained at each client device by training a machine-learning program with app usage data. The server generates synthetic data using the models from the client devices. A machine-learning program is trained using the synthetic data to obtain a global model, which receives as input information about recent commands entered on the app and generates an output with a prediction for the next command expected to be received by the app. The information of the global model is transmitted to a first client device, and the app provides at least one command option in the app user interface based on a prediction, generated by the global model, of the next command expected.

Abstract: An apparatus, method and computer program are described. The apparatus comprises throttling control circuitry (215), associated with a given processing element (205), to perform a throttling-level selection process to select a throttling level indicative of an execution rate at which higher-power processing tasks received by the given processing element are to be issued to processing circuitry of the given processing element. The apparatus also comprises power management circuitry (220) to perform a power control process to select an operating voltage and/or clock frequency to be used by the given processing element, wherein the power management circuitry is configured to select the operating voltage and/or clock frequency in dependence on the throttling level selected for the given processing element, and at least one register (225) accessible to firmware.

Abstract: In various implementations, a manual actuator may be coupled to a valve to provide the ability to shut off anhydrous ammonia flow through the valve remotely (e.g., in emergencies). The valve may be coupled to anhydrous ammonia tanks, such as nurse tanks and/or storage tanks. The manual actuator may include manual release member, a breakaway member, a handle, and pull cord(s). The handle may allow a coupled valve to be opened and/or closed. The handle may allow the valve to be shut off at the valve, in some implementations. The pull cord(s) may allow a coupled valve to be remotely closed.

Abstract: In various implementations, an electronic actuator may be coupled to a valve to provide the ability to shut off anhydrous ammonia flow through the valve (e.g., in emergencies). The valve may be coupled to anhydrous ammonia tanks, such as nurse tanks and/or storage tanks. The electronic actuator may include a handle and a bracket. The handle and the bracket may include at least two attractive components that are magnetically attracted to each other upon application of an electric current and the valve may be open. When the electric current is cut, the attractive components of the handle and the bracket may not be magnetically attracted to each other and the valve may be shut off. A controller (e.g., a switch) may be coupled to the electronic actuator to allow control of the electric signal to the electronic actuator.