Abstract: The present disclosure provides LINE-1 inhibitors and methods of treating or preventing a disease, disorder, or condition in a subject in need thereof, the methods comprising administering to the subject a therapeutically effective amount of a LINE-1 inhibitor.

Abstract: A deposition aid is provided, comprising a low molecular weight, low viscosity polysiloxane, combined with a crop oil concentrate or esterified seed oil concentrate. Combinations including the modified silicone can improve spreading and/or adhesion to foliage. Adding about 5% to about 20% of the modified silicone can provide more than a proportional increase in spreading and/or adhesion.

Abstract: A system and method for detecting leaks in an enclosure having a port and intended to prevent liquid material from exchanging into or out of the enclosure. A vacuum pump is coupled to the port and the enclosure is subjected to an applied vacuum pressure. Measurements of the mass and pressure within the enclosure while subject to the applied vacuum pressure are compared to expected values to detect a leak. In some embodiments, the physical arrangement of a valve of the enclosure is measured and compared to expected values to detect a leak.

Abstract: A grid accessory attachment platform with a knitted textile that has a number of spaced slits integrally knit into the textile.

Abstract: The present disclosure provides DNA damage repair enzyme inhibitors and methods of treating or preventing a cancer in a subject by administering a DNA damage repair enzyme inhibitor to the subject.

Abstract: The present invention relates to polycyclic heterocyclic compounds and methods which may be useful as inhibitors of IGF-1R for the treatment or prevention of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO).

Abstract: The present invention relates to heterocyclic compounds, pharmaceutical compositions thereof, and methods which may be useful as inhibitors of IGF-1R for the treatment or prevention of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO).

Abstract: Disclosed herein are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, that are inhibitors of inhibitors of epidermal growth factor receptor (EGFR), including EGFR C797S mutants. Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Methods, compositions, and kits are provided for the detection of Influenza A in a test sample. The presence or absence of Influenza A in the sample is determined by nucleic acid based assays using primers and/or probes with excellent sensitivity, specificity and inclusivity for detecting Influenza A strains and/or subtypes Detection strategies may utilize loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.

Abstract: Methods, compositions, and kits are provided for the detection of Influenza B in a test sample. The presence or absence of Influenza B in the sample is determined by nucleic acid based assays using primers and/or probes with excellent sensitivity, specificity, and inclusivity for Influenza B strains and/or subtypes. Detection strategies may utilize loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.

Abstract: An algorithm releases answers to very large numbers of statistical queries, e.g., k-way marginals, subject to differential privacy. The algorithm answers queries on a private dataset using simple perturbation, and then attempts to find a synthetic dataset that most closely matches the noisy answers. The algorithm uses a continuous relaxation of the synthetic dataset domain which makes the projection loss differentiable, and allows the use of efficient machine learning optimization techniques and tooling. Rather than answering all queries up front, the algorithm makes judicious use of a privacy budget by iteratively and adaptively finding queries for which relaxed synthetic data has high error, and then repeating the projection. The algorithm is effective across a range of parameters and datasets, especially when a privacy budget is small or a query class is large.

Abstract: An optical coherence tomography (OCT) scan device includes an OCT scan device housing, an interferometer disposed within the OCT scan device housing and including a light source, a fiber optic coupler including an interferometer output, a reference-arm, and a sample-arm. The OCT scan device further includes a power source configured to provide power to the light source and the remaining components of the OCT scan device, and a controller disposed within the OCT scan device housing and configured to adjust lens focusing parameters in the reference-arm and the sample-arm, and control a scanning function of an optical beam emitting from the sample-arm. The OCT scan device is further configured to transmit and receive control instructions and transmit fundus image data.

Abstract: A door framing assembly comprises trim pieces for overlying a wall to conceal a rough opening. The trim pieces are held together using a plurality of brackets positioned along an axis of the trim pieces. The brackets hold the trim pieces in opposed, spaced apart relationship. The brackets have holes for securing to framing members defining the rough opening. A pocket is defined between the trim pieces for reception of a jamb. Flanges of the brackets are received in slots of the trim pieces, allowing pivoting of the trim pieces to fit tightly against the wall.

Abstract: A deposition aid is provided, comprising a low molecular weight, low viscosity polysiloxane, combined with a crop oil concentrate or esterified seed oil concentrate. Combinations including the modified silicone can improve spreading and/or adhesion to foliage. Adding about 5%to about 20%of the modified silicone can provide more than a proportional increase in spreading and/or adhesion.

Abstract: A system and method for detecting leaks in an enclosure having a port and intended to prevent liquid material from exchanging into or out of the enclosure. A vacuum pump is coupled to the port and the enclosure is subjected to an applied vacuum pressure. Measurements of the mass and pressure within the enclosure while subject to the applied vacuum pressure are compared to expected values to detect a leak. In some embodiments, the physical arrangement of a valve of the enclosure is measured and compared to expected values to detect a leak.

Abstract: An optical coherence tomography (OCT) scan device includes an OCT scan device housing, an interferometer disposed within the OCT scan device housing and including a light source, a fiber optic coupler including an interferometer output, a reference-arm, and a sample-arm. The OCT scan device further includes a power source configured to provide power to the light source and the remaining components of the OCT scan device, and a controller disposed within the OCT scan device housing and configured to adjust lens focusing parameters in the reference-arm and the sample-arm, and control a scanning function of an optical beam emitting from the sample-arm. The OCT scan device is further configured to transmit and receive control instructions and transmit fundus image data.

Abstract: An algorithm releases answers to very large numbers of statistical queries, e.g., k-way marginals, subject to differential privacy. The algorithm answers queries on a private dataset using simple perturbation, and then attempts to find a synthetic dataset that most closely matches the noisy answers. The algorithm uses a continuous relaxation of the synthetic dataset domain which makes the projection loss differentiable, and allows the use of efficient machine learning optimization techniques and tooling. Rather than answering all queries up front, the algorithm makes judicious use of a privacy budget by iteratively and adaptively finding queries for which relaxed synthetic data has high error, and then repeating the projection. The algorithm is effective across a range of parameters and datasets, especially when a privacy budget is small or a query class is large.

Abstract: An optical coherence tomography (OCT) scan device includes an OCT scan device housing, an interferometer disposed in within the OCT scan device housing and including a light source, a fiber optic coupler including an interferometer output, a reference-arm, and a sample-arm. The OCT scan device further includes a power source configured to provide power to the light source and the remaining components of the OCT scan device, and a controller disposed within the OCT scan device housing and configured to adjust lens focusing parameters in the reference-arm and the sample-arm, and control a scanning function of an optical beam emitting from the sample-arm. The OCT scan device is further configured to transmit and receive control instructions and transmit fundus image data.

Abstract: Methods and systems are provided for personalizing a free-form communicative system. The free-from communicative system allows a service provider to autonomously communicate with a user. The free-form communicative system may use an adaptive communicative application and natural language adaptive components to interact with the user. The communicative system may be configured to receive an inbound message from the user and maintain a conversation with the user in their own natural language. The communicative system may assess the inbound message and generate labels, packages, and blueprint objects related to the input message. The communicative system may generate personalized sentences based on the respective labels, packages, and blueprint objects as well as message templates. In response to the input message, the communicative system sends the personalized sentences as an output message to the user, where the personalized sentences are commensurate to the conversation and natural language of the user.

Abstract: Methods and compositions are described that remove chlorine from a chlorine-containing gas stream. The method includes adding a carbonate salt and optionally a scale inhibitor to a scrubbing liquid in a wet scrubbing system, and contacting the chlorine-containing gas with the scrubbing liquid. The amount of carbonate salt that is added can vary depending on the pH of the scrubbing liquid.