Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Systems and methods are described for managing personal data on a client computer, in which personal data associated with the client computer is identified by a policy management module. An analysis may be performed for the client computer by a server using fake personal data. To identify applications which may attempt to access the personal data, the fake personal data is tracked for access on the client computer. A policy is then created that disallows access of the personal data by any applications identified by the analysis of the client computer as accessing the fake personal data. The policy is then assigned to the client computer.

Abstract: A method for locating a mobile device which is not in possession of the owner using an owner verification server. A mobile network operator server sends a message to the owner verification server requesting verification of ownership. The owner verification server retrieves ownership status and transmits a request to the mobile network operator server to transmit location tracking data when the ownership status indicates that the device is not in the owner's possession. The owner verification server forwards the location tracking data to the device owner.

Abstract: An adjustable light fixture includes a frame configured to connect to a support. A lamp assembly is connected to the frame. The lamp assembly includes a housing, a light emitter connected to the housing, and a lens connected to the housing. The lamp assembly is rotatably connected to the frame about an axis offset from an axis of the frame.

Abstract: An adjustable light fixture includes a frame configured to connect to a support. A lamp assembly is connected to the frame. The lamp assembly includes a housing, a light emitter connected to the housing, and a lens connected to the housing. The lamp assembly is rotatably connected to the frame about an axis offset from an axis of the frame.

Abstract: A garbage bag retaining clip apparatus for securing garbage bag excess includes a housing having an open front side separated from an open back side, a top side separated from an open bottom side, and a left side separated from a right side defining a housing inside. A bag gate is flexibly coupled within the housing inside. The bag gate is biased to rest in the pinch position. A plurality of parallel retaining ridges is coupled to the housing. Each of the retaining ridges extends vertically from the right side and the left side within the housing inside. A tab is coupled to the housing. The tab proximal end has a hinge extending between the left side and the right side proximal the top side and the back side. The tab moves between a locked position engaged within the retaining ridges and a released position extending behind the housing.

Abstract: An adjustable light fixture includes a frame configured to connect to a support. A lamp assembly is connected to the frame. The lamp assembly includes a housing, a light emitter connected to the housing, and a lens connected to the housing. The lamp assembly is rotatably connected to the frame about an axis offset from an axis of the frame.

Abstract: A garbage bag retaining clip apparatus for securing garbage bag excess includes a housing having an open front side separated from an open back side, a top side separated from an open bottom side, and a left side separated from a right side defining a housing inside. A bag gate is flexibly coupled within the housing inside. The bag gate is biased to rest in the pinch position. A plurality of parallel retaining ridges is coupled to the housing. Each of the retaining ridges extends vertically from the right side and the left side within the housing inside. A tab is coupled to the housing. The tab proximal end has a hinge extending between the left side and the right side proximal the top side and the back side. The tab moves between a locked position engaged within the retaining ridges and a released position extending behind the housing.

Abstract: The invention provides humanized antibody and other antigen-binding fragments that are specific for the newly identified dendritic cell marker BDCA-2. These agents may be used for treatment of conditions caused or mediated by dendritic cells, including but not limited to systemic lupus erythematosus (SLE). The invention includes pharmaceutical compositions that contain a means for specifically binding BDCA-2, methods of preparing therapeutic products, and their use in therapy. Methods are also provided for screening, manufacture, and use of specific antibodies that identify other dendritic cell markers.

Abstract: This invention provides a method of detecting BDCA-2 protein in a biological sample. The sample is combined with an antibody or antigen binding fragment under conditions where the antibody or fragment will bind to BDCA-2 protein in the sample to form a complex, which is detected by formation of complex with the antibody. BDCA-2 protein may be displayed on the surface of dendritic cells. Binding of the antibody may result in down-regulation of type 1 interferon production, down-regulation of Th1 immune responses, induction of intracellular Ca++ mobilization, and/or polarization of an immune response towards Th2.

Abstract: A collapsible durable outdoor adventure container is constructed of polymer sheeting having holes in flaps of the sheeting. The sheet is bendable and bent by a user to a selected tubular configuration to align through holes along a seam line in flaps of the sheet or sheeting assembly with cable tie clamping elements clamping said flaps together through the holes. A strap coupled to at least several of the clamping element running along the seam line acting as an outside wrapping and/or tensioning element to contain the clamped flaps and fully or partially contain the contents of the container providing a connection tensioning element between adjacent clamping elements as connected along the seam line of the flaps.

Abstract: The invention provides antigen-binding fragments specific for dendritic cells and effective in treatment and/or diagnosing a variety of disorders. Methods of use are also provided as are methods for screening for additional such antigen-binding fragments and the products obtained thereby.

Abstract: The invention provides antigen-binding fragments specific for dendritic cells and effective in treatment and/or diagnosing a variety of disorders. Methods of use are also provided as are methods for screening for additional such antigen-binding fragments and the products obtained thereby.

Abstract: The invention provides antigen-binding fragments specific for dendritic cells and effective in treatment and/or diagnosing a variety of disorders. Methods of use are also provided as are methods for screening for additional such antigen-binding fragments and the products obtained thereby.

Abstract: The application describes, inter alia, a method for isolating or enriching for dendritic cells from a mixture of human cells involving contacting cells in the mixture with an antibody that binds BDCA-4, or antigen-binding fragment thereof, under conditions in which the antibody or antigen-binding fragment binds BDCA-4+ dendritic cells, and separating dendritic cells bound by the antibody or antigen-binding fragment from other cells in the mixture.

Abstract: A portable hand tool includes a housing with a handle configured to be carried by a user and a motor with a motor shaft rotatably extending therefrom. An output shaft rotatably connected to the motor shaft, upon which a cutting blade is rotatably fixed. The cutting blade is substantially enclosed within a blade guard. An impeller is rotatably mounted with one of the motor shaft or the output shaft and substantially enclosed within a fan housing. A plenum is configured to provide enclosed fluid communication between the blade guard and the fan housing, and at least one aperture defined in the blade guard in communication with the plenum.

Abstract: A chuck for use with a manual or powered driver having a housing and a rotatable drive shaft extending therefrom is provided. The chuck includes a generally cylindrical body member having a nose section and a tail section. Each of a plurality of jaws is slidably positioned in one of a plurality of angularly disposed passageways in the body. Each jaw has a jaw face formed on one side thereof and threads formed on the opposite side thereof. A nut is rotatably mounted on the body in engagement with the jaw threads so that rotation of the nut moves the jaws axially within the passageways. A locking member, in a first axial position, is rotatable with respect to the driver housing. In a second axial position, it operatively engages the housing and the nut so that the locking member is rotationally held to the housing and the nut so that the nut is rotationally held to the housing. The locking member is axially reciprocal between the first axial position and the second axial position.

Abstract: A lubricating oil composition is disclosed. This composition, comprises a lubricating oil basestock, an alkylated aromatic additive of at least 0.01 and less than 20 weight percent of the composition, a dispersant-detergent-inhibitor system of less than 15 percent weight percent of the composition, a zinc dithiophosphate additive of at least 0.1 weight percent of the composition and no more than 1.0 weight percent of the composition, the composition having less than 630 PPM phosphorus, less than 710 PPM zinc, less than 5,000 PPM sulfur, less than 8 TBN, less than 1.0 weight percent ash. In a second embodiment, an additive composition for lubricating oils is disclosed. In a third embodiment, a method of obtain a favorable lubricating properties is disclosed.

Abstract: A table saw comprising a table including an aperture to receive a portion of a rotatable saw blade extending from below the table and a riving knife extending through the aperture from below the table. The riving knife includes a slot that receives a first pin and the riving knife includes a plurality of recesses. A cam that operatively engages the first pin and is rotatable to cause linear motion of the first pin with respect to the slot such that when the cam is in a first position the riving knife may be retained in a selected position and when the cam is in a second position the riving knife may be movable to another selected position, wherein the rotation of the cam additionally causes movement of a second pin that may be received within one of the plurality of recesses.

Abstract: An improved riving knife/guard assembly that provides a viewing slot on a guard top plate to allow for sufficient observation of the cutting zone during table saw operations, while providing protection to minimize the likelihood of contact the rotating saw blade during use.