Abstract: Described embodiments are directed toward prosthetic valves and systems and methods of making prosthetic valves. For example, a prosthetic valve can comprise a frame defining a generally tubular shape and comprising frame members defining an open pattern of apertures, where the open pattern of apertures includes a plurality of windows and a plurality of circumferentially extending rows of apertures. Each window has a first width, each aperture of the circumferentially extending rows of apertures has a second width, the first width being at least double the second width, and the widths defined in the circumferential direction. The prosthetic valve can further comprise a plurality of leaflets formed from a single sheet of material, where the plurality of leaflets extends from the frame.

Abstract: Described embodiments are directed toward prosthetic valves having leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic valve has a plurality of leaflets. Each leaflet includes a central region and two side regions on opposite sides of the central region. The central region is defined by a shape of an isosceles triangle defined by two central region sides, the leaflet base and the leaflet free edge, wherein the two central region sides converge from the leaflet base. Each of the two side regions has a shape of a triangle and each is defined by one of the central region sides, one of the leaflet sides, and the leaflet free edge.

Abstract: Valves are disclosed that include an outer frame forming an annular structure, an inner frame nested coaxially within an inner diameter of the outer frame, the inner frame including a plurality of posts on an outflow end thereof, wherein a majority of an axial dimension of the inner frame is disposed between axial inflow and outflow ends of the outer frame, and a plurality of leaflets supported by the inner frame. Valves are disclosed that include an outer frame having an annular form, an inner frame that is coaxial with and nested within the outer frame, and a plurality of leaflets supported by the inner frame, wherein leaflet commissure posts associated with the plurality of leaflets are not held in fixed engagement with the outer frame, such that the leaflet commissure posts are operable to flex under loading during valve operation.

Abstract: Described embodiments are directed toward prosthetic valves and systems and methods of making prosthetic valves. In accordance with an embodiment, a prosthetic valve comprises and leaflet frame, and outer frame and a film. The leaflet frame has a generally tubular shape defining a plurality of leaflet windows. The outer frame has a generally tubular shape. The leaflet frame is coaxially disposed at least partially within the outer frame. The leaflet frame and outer frame is coupled at least in part by a contiguous portion of the film. At least a portion of the contiguous portion of the film is contained between and coupling the leaflet frame and outer frame operable to prevent relative movement and contact therebetween. The film defines a leaflet extending from each of the leaflet windows.

Abstract: Described embodiments are directed toward prosthetic valves having leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic valve has a plurality of leaflets. Each leaflet includes a central region and two side regions on opposite sides of the central region. The central region is defined by a shape of an isosceles triangle defined by two central region sides, the leaflet base and the leaflet free edge, wherein the two central region sides converge from the leaflet base. Each of the two side regions has a shape of a triangle and each is defined by one of the central region sides, one of the leaflet sides, and the leaflet free edge.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame coaxially disposed within a body frame, as well as methods of making the valve devices.

Abstract: A method can comprise: positioning a prosthetic heart valve in a collapsed configuration at an implantation site. In some examples, the prosthetic heart valve can comprise: a multi-part frame having a body frame and a leaflet frame, and at least one leaflet coupled to the multi-part frame. In some examples, the prosthetic heart valve can be expandable between the collapsed configuration and an expanded configuration. The method can further comprise expanding the prosthetic heart valve to the expanded configuration at the implantation site, transitioning the multi-part frame of the prosthetic heart valve from a non-everted configuration to an everted configuration, and securing the prosthetic heart valve at the implantation site.

Abstract: A leaflet support device can be configured to improve the competence of a native heart valve. In some examples, the leaflet support device can include a frame and a support leaflet coupled to the frame. The support leaflet can include a support leaflet free edge configured to move correspondingly with a leaflet of the native heart valve to an open position and move correspondingly with the leaflet of the native heart valve to a closed position.

Abstract: A prosthetic heart valve can include a frame defining a central longitudinal axis and a plurality of leaflets. Each leaflet can include: a leaflet free edge, a first leaflet side forming a first leaflet side line of attachment along the frame, a second leaflet side forming a second leaflet side line of attachment along the frame, and a leaflet base forming a leaflet base line of attachment along the frame from an end of the first leaflet side line of attachment to an end of the second leaflet side line of attachment. The first leaflet side line of attachment can form a continuous attachment of the first leaflet side to the frame along an entire extent of the first leaflet side. The second leaflet side line of attachment can form a continuous attachment of the second leaflet side to the frame along an entire extent of the second leaflet side.

Abstract: Described embodiments are directed toward prosthetic valve leaflets of particular configurations that control bending character. In embodiments provided herein, valve leaflets are operable to bend along a base of the valve leaflets.

Abstract: Described embodiments are directed toward centrally-opening, leaflet valve devices and systems for transcatheter delivery having a two-piece valve body as well as methods of making and delivering the two-piece valve devices. A transcatheter valve includes a collapsed configuration and an expanded configuration. The transcatheter valve can further include an everted configuration and a non-everted configuration.

Abstract: Described embodiments are directed toward centrally-opening leaflet support devices having a frame and one or more support leaflets coupled to the frame forming a hinge where coupled. The described support leaflets have one or more stiffer regions that facilitate the function of a support leaflet to decrease or prevent prolapse of a native valve leaflet. Methods of making and using such valve devices are also described amongst others.

Abstract: Described embodiments are directed toward prosthetic valve leaflets of a particular shape that allows redundant coaptation height in the leaflets when a planar segment is present in each leaflet.

Abstract: Described embodiments are directed toward prosthetic valves having leaflets of a particular shape that improves bending character without requiring a long length valve. In accordance with an embodiment, a prosthetic valve comprises a leaflet frame, a plurality of leaflets that are coupled to the leaflet frame, where each leaflet has a free edge and a base. The base of each leaflet is truncated in which the leaflet in cross section shows a line in an alpha plane onto the leaflet frame.

Abstract: Described embodiments are directed toward prosthetic valve leaflets of particular configurations that control bending character. In embodiments provided herein, valve leaflets are operable to bend along a base of the valve leaflets.

Abstract: Described embodiments are directed toward prosthetic valve leaflets of a particular shape that allows redundant coaptation height in the leaflets when a planar segment is present in each leaflet.

Abstract: Described embodiments are directed toward centrally-opening, leaflet valve devices and systems for transcatheter delivery having a two-piece valve body as well as methods of making and delivering the two-piece valve devices. A transcatheter valve includes a collapsed configuration and an expanded configuration. The transcatheter valve can further include an everted configuration and a non-everted configuration.

Abstract: Described embodiments are directed toward centrally-opening, leaflet valve devices and systems for transcatheter delivery having a two-piece valve body as well as methods of making and delivering the two-piece valve devices. A transcatheter valve includes a collapsed configuration and an expanded configuration. The transcatheter valve can further include an everted configuration and a non-everted configuration.

Abstract: A leaflet for a prosthetic valve formed of at least one layer that includes a composite material containing at least one expanded fluoropolymer membrane having serpentine fibrils and an elastomer is provided. The fluoropolymer may be polytetrafluoroethylene. In at least one embodiment, the elastic properties are present in an axial direction the leaflet. The leaflets may be single layered or multi-layered. The leaflets may be coupled to a support structure and movable between open and closed configurations relative to the support structure to form a heart valve. The elasticity within the leaflets permits, among other things, the leaflets to bend with a reduced occurrence of wrinkles as the valve opens and closes. The elastic properties of the leaflet also, among other things, improve bending properties and reduce closure stresses, thereby extending the life of the leaflet.

Abstract: Described embodiments are directed toward prosthetic valves having leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic valve has a plurality of leaflets. Each leaflet includes a central region and two side regions on opposite sides of the central region. The central region is defined by a shape of an isosceles triangle defined by two central region sides, the leaflet base and the leaflet free edge, wherein the two central region sides converge from the leaflet base. Each of the two side regions has a shape of a triangle and each is defined by one of the central region sides, one of the leaflet sides, and the leaflet free edge.