Patents by Inventor William C. Fioretti

William C. Fioretti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9157097
    Abstract: The present invention provides novel compositions to transfect cells for production of growth hormone (GH). These novel compositions also are used to produce germline transgenic birds that can successfully pass the transgene encoding growth hormone to their offspring. These novel compositions include components of vectors such as a vector backbone, a novel promoter, and a gene of interest that encodes for GH, and the vectors comprising these components. In one embodiment these vectors are transposon-based vectors. The present invention also provides methods of making these compositions and methods of using these compositions for the production of GH in vitro and in vivo. In one embodiment the GH is human (h)GH.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: October 13, 2015
    Assignee: PROTEOVEC HOLDING, L.L.C.
    Inventors: Richard K. Cooper, William C. Fioretti
  • Patent number: 9150880
    Abstract: Novel compositions for the production of the light and heavy chains of an antibody are provided. These novel compositions are also used to produce germline transgenic birds that can successfully pass the transgene encoding the antibody to their offspring. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes the light or heavy chain of an antibody, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of the light and heavy chains of an antibody. In one embodiment, the antibody is a human monoclonal antibody.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: October 6, 2015
    Assignee: PROTEOVEC HOLDING, L.L.C.
    Inventors: Richard K. Cooper, William C. Fioretti
  • Patent number: 9150881
    Abstract: Novel compositions for the in vitro or in vivo production of specific proteins are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes for the protein of interest, and the transposon-based vectors comprising these components. Also provided are methods of making these compositions and methods of using these compositions for the production of desired proteins in vivo or in transfected cells in vitro.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: October 6, 2015
    Assignee: PROTEOVEC HOLDING, L.L.C.
    Inventors: Richard K. Cooper, William C. Fioretti
  • Publication number: 20120297493
    Abstract: Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or human.
    Type: Application
    Filed: July 31, 2012
    Publication date: November 22, 2012
    Applicants: TransGenRx, Inc., The Board of Supervisors of Louisiana State Univ. and Agricultural and Mechanical College
    Inventors: Richard Cooper, Frederick M. Enright, William C. Fioretti
  • Patent number: 8283518
    Abstract: Methods and compositions for the administration of transposon-based vectors to the reproductive organs of animals and the creation of transgenic animals. Preferred methods involve administration of the transposon-based vectors to the lumen of the oviduct of an avian, expression of a vector derived transgene in the avian, and deposition of the resultant polypeptide in an egg. This invention allows for large amounts of protein to be deposited in the egg.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 9, 2012
    Assignees: TransGenRx, Inc., The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Richard K. Cooper, William C. Fioretti, Gary G. Cadd
  • Patent number: 8236294
    Abstract: Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or human.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: August 7, 2012
    Assignees: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, TransGenRx, Inc.
    Inventors: Richard K. Cooper, Frederick M. Enright, William C. Fioretti
  • Patent number: 8071364
    Abstract: Methods and compositions are presented for the administration of transposon based vectors to an animal or human to provide gene therapy to the animal or human.
    Type: Grant
    Filed: December 24, 2004
    Date of Patent: December 6, 2011
    Assignees: TransGenRx, Inc., The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Richard Cooper, Frederick M. Enright, William C. Fioretti
  • Publication number: 20110162096
    Abstract: Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or human
    Type: Application
    Filed: November 8, 2010
    Publication date: June 30, 2011
    Applicants: College, TransGenRx, Inc.
    Inventors: Richard Cooper, Frederick M. Enright, William C. Fioretti
  • Publication number: 20100261227
    Abstract: Novel compositions for the in vitro or in vivo production of specific proteins are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes for the protein of interest, and the transposon-based vectors comprising these components. Also provided are methods of making these compositions and methods of using these compositions for the production of desired proteins in vivo or in transfected cells in vitro.
    Type: Application
    Filed: April 9, 2010
    Publication date: October 14, 2010
    Applicants: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, TransGenRx, Inc.
    Inventors: Richard K. Cooper, William C. Fioretti
  • Publication number: 20100199366
    Abstract: Methods and compositions are presented for the administration of transposon based vectors to an animal or human to provide gene therapy to the animal or human.
    Type: Application
    Filed: December 24, 2004
    Publication date: August 5, 2010
    Inventors: Richard Cooper, Frederick M. Enright, William C. Fioretti
  • Publication number: 20100099148
    Abstract: Novel compositions for the production of the light and heavy chains of an antibody are provided. These novel compositions are also used to produce germline transgenic birds that can successfully pass the transgene encoding the antibody to their offspring. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes the light or heavy chain of an antibody, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of the light and heavy chains of an antibody. In one embodiment, the antibody is a human monoclonal antibody.
    Type: Application
    Filed: September 25, 2009
    Publication date: April 22, 2010
    Inventors: Richard K. Cooper, William C. Fioretti
  • Publication number: 20100093036
    Abstract: The present invention provides novel compositions to transfect cells for production of growth hormone (GH). These novel compositions also are used to produce germline transgenic birds that can successfully pass the transgene encoding growth hormone to their offspring. These novel compositions include components of vectors such as a vector backbone, a novel promoter, and a gene of interest that encodes for GH, and the vectors comprising these components. In one embodiment these vectors are transposon-based vectors. The present invention also provides methods of making these compositions and methods of using these compositions for the production of GH in vitro and in vivo. In one embodiment the GH is human (h)GH.
    Type: Application
    Filed: September 25, 2009
    Publication date: April 15, 2010
    Inventors: RICHARD K. COOPER, WILLIAM C. FIORETTI
  • Publication number: 20100081789
    Abstract: Novel compositions for the production of interferons such as interferon-? 2a, interferon-? 2b, or interferon-? 1a (IFN-? 2a, IFN-? 2b, or IFN-? 1a) are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes an interferon such as IFN-? 2a, IFN-? 2b, or IFN-? 1a, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of an interferon such as IFN-? 2a, IFN-? 2b, or IFN-?1a.
    Type: Application
    Filed: September 25, 2009
    Publication date: April 1, 2010
    Inventors: RICHARD K. COOPER, WILLIAM C. FIORETTI
  • Patent number: 7608451
    Abstract: Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 27, 2009
    Assignees: Transgen Rx, Inc., The Board of Supervisors of Louisiana State University and Mechanical College
    Inventors: Richard K. Cooper, Gary G. Cadd, William C. Fioretti, Kenneth F. De Boer
  • Patent number: 7527966
    Abstract: Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: May 5, 2009
    Assignees: TransGenRx, Inc., The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Richard K. Cooper, Gary G. Cadd, William C. Fioretti, Kenneth F. De Boer
  • Publication number: 20090004220
    Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.
    Type: Application
    Filed: September 11, 2008
    Publication date: January 1, 2009
    Applicant: MANNATECH, INCORPORATED
    Inventors: Bill H. McAnalley, H. Reginald McDaniel, D. Eric Moore, Eileen P. Vennum, William C. Fioretti
  • Publication number: 20080235813
    Abstract: Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 25, 2008
    Inventors: Richard K. Cooper, Gary G. Cadd, William C. Fioretti, Kenneth F. De Boer
  • Publication number: 20080235815
    Abstract: Methods and compositions for the administration of transposon-based vectors to the reproductive organs of animals and the creation of transgenic animals. Preferred methods involve administration of the transposon-based vectors to the lumen of the oviduct of an avian, expression of a vector derived transgene in the avian, and deposition of the resultant polypeptide in an egg. This invention allows for large amounts of protein to be deposited in the egg.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 25, 2008
    Inventors: Richard K. Cooper, William C. Fioretti, Gary G. Cadd
  • Patent number: 7202220
    Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: April 10, 2007
    Assignee: Mannatech, Inc.
    Inventors: Bill H. McAnalley, H. Reginald McDaniel, D. Eric Moore, Eileen P. Vennum, William C. Fioretti
  • Patent number: 7199104
    Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: April 3, 2007
    Assignee: Mannatech, Inc.
    Inventors: Bill H. McAnalley, H. Reginald McDaniel, D. Eric Moore, Eileen P. Vennum, William C. Fioretti