Patents by Inventor William C. Fioretti
William C. Fioretti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9157097Abstract: The present invention provides novel compositions to transfect cells for production of growth hormone (GH). These novel compositions also are used to produce germline transgenic birds that can successfully pass the transgene encoding growth hormone to their offspring. These novel compositions include components of vectors such as a vector backbone, a novel promoter, and a gene of interest that encodes for GH, and the vectors comprising these components. In one embodiment these vectors are transposon-based vectors. The present invention also provides methods of making these compositions and methods of using these compositions for the production of GH in vitro and in vivo. In one embodiment the GH is human (h)GH.Type: GrantFiled: September 25, 2009Date of Patent: October 13, 2015Assignee: PROTEOVEC HOLDING, L.L.C.Inventors: Richard K. Cooper, William C. Fioretti
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Patent number: 9150881Abstract: Novel compositions for the in vitro or in vivo production of specific proteins are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes for the protein of interest, and the transposon-based vectors comprising these components. Also provided are methods of making these compositions and methods of using these compositions for the production of desired proteins in vivo or in transfected cells in vitro.Type: GrantFiled: April 9, 2010Date of Patent: October 6, 2015Assignee: PROTEOVEC HOLDING, L.L.C.Inventors: Richard K. Cooper, William C. Fioretti
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Patent number: 9150880Abstract: Novel compositions for the production of the light and heavy chains of an antibody are provided. These novel compositions are also used to produce germline transgenic birds that can successfully pass the transgene encoding the antibody to their offspring. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes the light or heavy chain of an antibody, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of the light and heavy chains of an antibody. In one embodiment, the antibody is a human monoclonal antibody.Type: GrantFiled: September 25, 2009Date of Patent: October 6, 2015Assignee: PROTEOVEC HOLDING, L.L.C.Inventors: Richard K. Cooper, William C. Fioretti
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Publication number: 20120297493Abstract: Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or human.Type: ApplicationFiled: July 31, 2012Publication date: November 22, 2012Applicants: TransGenRx, Inc., The Board of Supervisors of Louisiana State Univ. and Agricultural and Mechanical CollegeInventors: Richard Cooper, Frederick M. Enright, William C. Fioretti
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Patent number: 8283518Abstract: Methods and compositions for the administration of transposon-based vectors to the reproductive organs of animals and the creation of transgenic animals. Preferred methods involve administration of the transposon-based vectors to the lumen of the oviduct of an avian, expression of a vector derived transgene in the avian, and deposition of the resultant polypeptide in an egg. This invention allows for large amounts of protein to be deposited in the egg.Type: GrantFiled: October 31, 2007Date of Patent: October 9, 2012Assignees: TransGenRx, Inc., The Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Richard K. Cooper, William C. Fioretti, Gary G. Cadd
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Patent number: 8236294Abstract: Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or human.Type: GrantFiled: November 8, 2010Date of Patent: August 7, 2012Assignees: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, TransGenRx, Inc.Inventors: Richard K. Cooper, Frederick M. Enright, William C. Fioretti
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Patent number: 8071364Abstract: Methods and compositions are presented for the administration of transposon based vectors to an animal or human to provide gene therapy to the animal or human.Type: GrantFiled: December 24, 2004Date of Patent: December 6, 2011Assignees: TransGenRx, Inc., The Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Richard Cooper, Frederick M. Enright, William C. Fioretti
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Publication number: 20110162096Abstract: Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or humanType: ApplicationFiled: November 8, 2010Publication date: June 30, 2011Applicants: College, TransGenRx, Inc.Inventors: Richard Cooper, Frederick M. Enright, William C. Fioretti
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Publication number: 20100261227Abstract: Novel compositions for the in vitro or in vivo production of specific proteins are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes for the protein of interest, and the transposon-based vectors comprising these components. Also provided are methods of making these compositions and methods of using these compositions for the production of desired proteins in vivo or in transfected cells in vitro.Type: ApplicationFiled: April 9, 2010Publication date: October 14, 2010Applicants: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, TransGenRx, Inc.Inventors: Richard K. Cooper, William C. Fioretti
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Publication number: 20100199366Abstract: Methods and compositions are presented for the administration of transposon based vectors to an animal or human to provide gene therapy to the animal or human.Type: ApplicationFiled: December 24, 2004Publication date: August 5, 2010Inventors: Richard Cooper, Frederick M. Enright, William C. Fioretti
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Publication number: 20100099148Abstract: Novel compositions for the production of the light and heavy chains of an antibody are provided. These novel compositions are also used to produce germline transgenic birds that can successfully pass the transgene encoding the antibody to their offspring. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes the light or heavy chain of an antibody, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of the light and heavy chains of an antibody. In one embodiment, the antibody is a human monoclonal antibody.Type: ApplicationFiled: September 25, 2009Publication date: April 22, 2010Inventors: Richard K. Cooper, William C. Fioretti
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Publication number: 20100093036Abstract: The present invention provides novel compositions to transfect cells for production of growth hormone (GH). These novel compositions also are used to produce germline transgenic birds that can successfully pass the transgene encoding growth hormone to their offspring. These novel compositions include components of vectors such as a vector backbone, a novel promoter, and a gene of interest that encodes for GH, and the vectors comprising these components. In one embodiment these vectors are transposon-based vectors. The present invention also provides methods of making these compositions and methods of using these compositions for the production of GH in vitro and in vivo. In one embodiment the GH is human (h)GH.Type: ApplicationFiled: September 25, 2009Publication date: April 15, 2010Inventors: RICHARD K. COOPER, WILLIAM C. FIORETTI
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Publication number: 20100081789Abstract: Novel compositions for the production of interferons such as interferon-? 2a, interferon-? 2b, or interferon-? 1a (IFN-? 2a, IFN-? 2b, or IFN-? 1a) are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes an interferon such as IFN-? 2a, IFN-? 2b, or IFN-? 1a, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of an interferon such as IFN-? 2a, IFN-? 2b, or IFN-?1a.Type: ApplicationFiled: September 25, 2009Publication date: April 1, 2010Inventors: RICHARD K. COOPER, WILLIAM C. FIORETTI
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Patent number: 7608451Abstract: Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.Type: GrantFiled: October 31, 2007Date of Patent: October 27, 2009Assignees: Transgen Rx, Inc., The Board of Supervisors of Louisiana State University and Mechanical CollegeInventors: Richard K. Cooper, Gary G. Cadd, William C. Fioretti, Kenneth F. De Boer
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Patent number: 7527966Abstract: Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.Type: GrantFiled: June 26, 2003Date of Patent: May 5, 2009Assignees: TransGenRx, Inc., The Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Richard K. Cooper, Gary G. Cadd, William C. Fioretti, Kenneth F. De Boer
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Publication number: 20090004220Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.Type: ApplicationFiled: September 11, 2008Publication date: January 1, 2009Applicant: MANNATECH, INCORPORATEDInventors: Bill H. McAnalley, H. Reginald McDaniel, D. Eric Moore, Eileen P. Vennum, William C. Fioretti
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Publication number: 20080235813Abstract: Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.Type: ApplicationFiled: October 31, 2007Publication date: September 25, 2008Inventors: Richard K. Cooper, Gary G. Cadd, William C. Fioretti, Kenneth F. De Boer
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Publication number: 20080235815Abstract: Methods and compositions for the administration of transposon-based vectors to the reproductive organs of animals and the creation of transgenic animals. Preferred methods involve administration of the transposon-based vectors to the lumen of the oviduct of an avian, expression of a vector derived transgene in the avian, and deposition of the resultant polypeptide in an egg. This invention allows for large amounts of protein to be deposited in the egg.Type: ApplicationFiled: October 31, 2007Publication date: September 25, 2008Inventors: Richard K. Cooper, William C. Fioretti, Gary G. Cadd
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Patent number: 7202220Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.Type: GrantFiled: July 6, 2004Date of Patent: April 10, 2007Assignee: Mannatech, Inc.Inventors: Bill H. McAnalley, H. Reginald McDaniel, D. Eric Moore, Eileen P. Vennum, William C. Fioretti
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Patent number: 7199104Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.Type: GrantFiled: March 10, 2004Date of Patent: April 3, 2007Assignee: Mannatech, Inc.Inventors: Bill H. McAnalley, H. Reginald McDaniel, D. Eric Moore, Eileen P. Vennum, William C. Fioretti