Patents by Inventor William C. Karl
William C. Karl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130130926Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: ApplicationFiled: June 19, 2012Publication date: May 23, 2013Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
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Patent number: 8247240Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.Type: GrantFiled: May 18, 2010Date of Patent: August 21, 2012Assignee: X-Body, Inc.Inventors: Homer Paul Pien, William C. Karl, Derek Puff, Peter Li, Brian Cunningham
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Patent number: 8202735Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: GrantFiled: April 13, 2010Date of Patent: June 19, 2012Assignee: X-Body, Inc.Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
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Patent number: 8031927Abstract: In one aspect, the invention is a method of medical image processing. The method includes receiving data representing a medical image. The method also includes generating the medical image based on a model. The model characterizes the medical image as a composition of at least two components having processing constraints.Type: GrantFiled: December 28, 2005Date of Patent: October 4, 2011Assignee: The General Hospital CorporationInventors: William C. Karl, Zhuangli Liang, Homer Pien, Thomas J. Brady
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Patent number: 7927822Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: GrantFiled: December 8, 2006Date of Patent: April 19, 2011Assignee: SRU Biosystems, Inc.Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
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Publication number: 20100231907Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.Type: ApplicationFiled: May 18, 2010Publication date: September 16, 2010Applicant: SRU BIOSYSTEMS, LLCInventors: Homer Pien, William C. Karl, Derek Puff, Peter Li, Brian Cunningham
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Publication number: 20100196925Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: ApplicationFiled: April 13, 2010Publication date: August 5, 2010Applicant: SRU Biosystems, Inc.Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
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Patent number: 7718440Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.Type: GrantFiled: May 15, 2007Date of Patent: May 18, 2010Assignee: SRU Biosystems, Inc.Inventors: Homer Paul Pien, William C. Karl, Derek Puff, Peter Li, Brian Cunningham
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Patent number: 7689017Abstract: In one aspect, the invention is a method to reduce a blooming effect of a bright object in a medical image generated from a low-dose imaging system. The method includes characterizing an ideal image as a composition of a first component and a second component. The first component is characterized by a first function and the second component is characterized by a second function. The method also includes minimizing the first function and the second function using a smoothing process and generating the medical image based on the minimizing.Type: GrantFiled: June 19, 2006Date of Patent: March 30, 2010Assignee: The General Hospital CorporationInventors: William C. Karl, Zhuangli Liang, Homer Pien, Thomas J. Brady
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Publication number: 20070147696Abstract: In one aspect, the invention is a method to reduce a blooming effect of a bright object in a medical image generated from a low-dose imaging system. The method includes characterizing an ideal image as a composition of a first component and a second component. The first component is characterized by a first function and the second component is characterized by a second function. The method also includes minimizing the first function and the second function using a smoothing process and generating the medical image based on the minimizing.Type: ApplicationFiled: June 19, 2006Publication date: June 28, 2007Inventors: William C. Karl, Zhuangli Liang, Homer Pien, Thomas J. Brady
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Patent number: 7217574Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.Type: GrantFiled: September 25, 2002Date of Patent: May 15, 2007Assignee: SRU Biosystems, Inc.Inventors: Homer Pien, William C. Karl, Derek Puff, Peter Li, Brian Cunningham
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Publication number: 20030077660Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.Type: ApplicationFiled: September 25, 2002Publication date: April 24, 2003Applicant: SRU BIOSYSTEMS, LLCInventors: Homer Pien, William C. Karl, Derek Puff, Peter Li, Brian Cunningham