Patents by Inventor William C. Lumma

William C. Lumma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents
    Patent number: 4966967
    Abstract: This invention relates to novel 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines and their pharmaceutically acceptable salts. The compounds of the invention are cardiovascular agents and especially Class III antiarrhythmic agents.
    Type: Grant
    Filed: September 15, 1989
    Date of Patent: October 30, 1990
    Assignee: Berlex Laboratories, Inc.
    Inventors: William C. Lumma, Jr., Gary B. Phillips
  • Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
    Patent number: 4906634
    Abstract: Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents, especially as antiarrhythmic agents are described. Pharmaceutical formulations containing such compounds are also discussed.
    Type: Grant
    Filed: March 8, 1988
    Date of Patent: March 6, 1990
    Assignee: Schering A.G.
    Inventors: Stanley S. Greenberg, William C. Lumma, Jr., Klaus Nickisch, Ronald A. Wohl
  • 1-(4-Substituted phenyl)-1H-imidazoles compounds
    Patent number: 4851526
    Abstract: Novel 1-(4-substituted phenyl)-1H-imidazoles and their use as antiarrhythmic, anti-hypertensive and anti-ischemic agents is described. Pharmaceutical formulations containing such compounds are also discussed.
    Type: Grant
    Filed: September 4, 1987
    Date of Patent: July 25, 1989
    Assignee: Schering A.G.
    Inventors: Stanley S. Greenberg, Randall E. Lis, William C. Lumma, Jr., Klaus Nickisch, Ronald A. Wohl
  • Substituted 4-(1H-imidazol-1-yl)benzamides as antiarrhythmic agents
    Patent number: 4804662
    Abstract: Novel substituted 4-[1H-imidazol-1-yl]benzamides and their use in the treatment of cardiac arrthythmias especially as Class III or combination Class I/III antiarrhythmic agents is described. Pharmaceutical formulations containing such compounds are also disclosed.
    Type: Grant
    Filed: May 5, 1987
    Date of Patent: February 14, 1989
    Assignee: Schering A.G.
    Inventors: Klaus Nickisch, Randall E. Lis, William C. Lumma, Jr., Thomas K. Morgan, Jr., Ronald A. Wohl
  • 3,5-diamino-1,2,4-oxidiazoles as gastric secretion inhibitors
    Patent number: 4772622
    Abstract: Novel diamino oxadiazoles, wherein one of the amine functions is connected to a basicly-substituted heterocyclic group through a linear or cyclic connecting group, which are useful for the suppression of gastric acid secretions in mammals. Compositions employing these compounds and processes for the preparation of such compounds from known N-cyano-S-methylisothiourea precursors by treatment with hydroxylamine and for alkylation of amine groups are also disclosed.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: September 20, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Susan F. Britcher, William C. Lumma, Jr.
  • Process for the preparation of imidazolonecarbonylarylimidazoles
    Patent number: 4709043
    Abstract: Novel imidazolonecarbonylarylimidazoles are described having cardiovascular properties, especially as cardiotonic agents in the treatment of congestive heart failure. Pharmaceutical formulations containing such compounds are also provided. Further, a novel process for the preparation of the compounds and intermediates useful thereto of this invention is disclosed.
    Type: Grant
    Filed: November 26, 1985
    Date of Patent: November 24, 1987
    Assignee: Schering A.G.
    Inventors: Paul W. Erhardt, Alfred A. Hagedorn, III, William C. Lumma, Jr., Ronald A. Wohl
  • Antiarrhythmic imidazoles
    Patent number: 4689341
    Abstract: The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.
    Type: Grant
    Filed: July 3, 1986
    Date of Patent: August 25, 1987
    Assignee: Schering A.G.
    Inventors: Julius Diamond, William C. Lumma, Jr., Thomas K. Morgan, Jr., Ronald A. Wohl
  • Substituted sulfonamidobenzamides and method of treating arrhythmias
    Patent number: 4629739
    Abstract: Novel substituted sulfonamidobenzamides are described as useful antiarrhythmic agents. Their use in the treatment of cardiac arrhythmias, especially re-entrant arrhythmias, via the prolongation of the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such compounds are also disclosed.
    Type: Grant
    Filed: September 23, 1985
    Date of Patent: December 16, 1986
    Assignee: Schering A.G.
    Inventors: David D. Davey, William C. Lumma, Jr., Ronald A. Wohl
  • Antiarrhythmic imidazoliums
    Patent number: 4613609
    Abstract: The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.
    Type: Grant
    Filed: November 27, 1984
    Date of Patent: September 23, 1986
    Assignee: Schering A. G.
    Inventors: Julius Diamond, William C. Lumma, Jr., Thomas K. Morgan, Jr., Ronald A. Wohl
  • Antiarrhythmic imidazoliums
    Patent number: 4581370
    Abstract: The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.
    Type: Grant
    Filed: July 12, 1983
    Date of Patent: April 8, 1986
    Assignee: Schering A.G.
    Inventors: Julius Diamond, William C. Lumma, Jr., Thomas K. Morgan, Jr., Ronald A. Wohl
  • Amino-phenyl-thiadiazoledioxides as gastric secretion inhibitors
    Patent number: 4567191
    Abstract: Novel amino-phenyl-thiadiazoledioxides and related compounds and processes for preparing such compounds are disclosed. The compounds are useful for suppressing gastric acid secretions in mammals.
    Type: Grant
    Filed: June 7, 1983
    Date of Patent: January 28, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Adolph Pietruszkiewicz, William A. Bolhofer, William C. Lumma, Jr.
  • Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
    Patent number: 4556665
    Abstract: Novel imidazolonecarbonylarylimidazoles of the formula: ##STR1## are described having cardiovascular properties, especially as cardiotonic agents in the treatment of congestive heart failure. Pharmaceutical formulations containing such compounds are also provided. Further, a novel process for the preparation of the compounds and intermediates useful thereto of this invention is disclosed.
    Type: Grant
    Filed: July 9, 1984
    Date of Patent: December 3, 1985
    Assignee: Schering A.G.
    Inventors: Paul W. Erhardt, Alfred A. Hagedorn, III, William C. Lumma, Jr., Ronald A. Wohl
  • Substituted phenylalkenyl ammonium salts as antiarrhythimc agents
    Patent number: 4545995
    Abstract: The novel unsaturated arylalkyl ammonium salts described herein are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided, as well as pharmaceutical formulations containing such ammonium salts.
    Type: Grant
    Filed: July 12, 1983
    Date of Patent: October 8, 1985
    Assignee: Schering A.G.
    Inventors: William C. Lumma, Jr., Ronald A. Wohl
  • Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
    Patent number: 4544654
    Abstract: Novel substituted sulfonamidobenzamides are described as useful antiarrhythmic agents. Their use in the treatment of cardiac arrhythmias, especially re-entrant arrhythmias, via the prolongation of the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such compounds are also disclosed.
    Type: Grant
    Filed: March 20, 1984
    Date of Patent: October 1, 1985
    Assignee: Schering A.G.
    Inventors: David D. Davey, William C. Lumma, Jr., Ronald A. Wohl
  • Substituted derivatives of amino alkane diols as gastric secretion inhibitors
    Patent number: 4411899
    Abstract: There are disclosed substituted derivatives of amino alkane diols and related compounds as well as processes for the preparation of such compounds. These compounds are useful for the suppression of gastric acid secretions in mammals and compositions for such uses are also disclosed.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: October 25, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, William C. Lumma, Jr.
  • Imidazodiazines
    Patent number: 4408047
    Abstract: Novel imidazopyridines, -pyrazines, -pyrimidines and -pyridazines having a 3-amino-2-OR-propoxy substituent, are disclosed. The compounds have .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: October 4, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, William C. Lumma, Jr.
  • Imidazoazines and imidazodiazines
    Patent number: 4330543
    Abstract: Novel imidazopyridines, -pyrazines, -pyrimidines and -pyridazines having a 3-amino-2-OR-propoxy substituent, are disclosed. The compounds have .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: March 28, 1980
    Date of Patent: May 18, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, William C. Lumma, Jr.
  • 2-{[4-(6-Substituted-2-pyrazinyl)- 1-piperazinyl]alkyl}-5-substituted-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one analgesic agents
    Patent number: 4251530
    Abstract: 2-{[4-(6-Substituted-2-pyrazinyl)-1-piperazinyl]alkyl}-5-substituted-1,2,4- triazolo[4,3-a]pyridin-3(2H)ones useful as analgesic agents, having the following formula: ##STR1## wherein p1 n is 2 to 4; R is halo, methyl, methoxy, or CF.sub.3 ; andR.sub.1 is H or methyl;and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: February 17, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Walfred S. Saari, William C. Lumma
  • Piperazinyl-imidazo[1,2-a]pyrazines
    Patent number: 4242344
    Abstract: Piperazinyl-imidazo[1,2-a]pyrazines, derived from reactions between halo-imidazo[1,2-a]pyrazines with piperazine derivatives, are found to be active anorexic, antidepressant, antihypertensive, analgesic, antiarrhythmic, and/or anti-smoking agents.
    Type: Grant
    Filed: September 7, 1979
    Date of Patent: December 30, 1980
    Assignee: Merck & Co., Inc.
    Inventor: William C. Lumma
  • Novel imidazoazines and imidazodiazines
    Patent number: 4233301
    Abstract: Novel imidazopyridines, -pyrazines, -pyrimidines and -pyridazines having a 3-amino-2-OR-propoxy substituent, are disclosed. The compounds have .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: December 14, 1978
    Date of Patent: November 11, 1980
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, William C. Lumma, Jr.