Abstract: Disclosed herein are biomarkers associated with a disease state such as lung cancer, and methods of discovering or using biomarkers. Also disclosed herein are classifiers built on biomarkers and methods of detecting the disease state in samples from subjects. The method may include obtaining a data set that includes protein information from a biofluid sample, and may involve using a classifier to identify the sample as indicative of a healthy state, a disease state, or a comorbidity.

Abstract: Disclosed herein are methods and compositions for processing biofluid samples. Some such methods may include obtaining a biofluid sample from a subject having a disease state such as lung cancer. The biofluid sample may be contacted with a nanoparticles to adsorb proteins. The proteins may then be ionized or contacted with a detection reagent. Also disclosed herein are compositions comprising proteins coupled to a nanoparticle upon contact of the nanoparticle with a biofluid sample from a subject having a disease.

Abstract: Disclosed herein are biomarkers associated with a disease state such as lung cancer, and methods of discovering or using said biomarkers. Also disclosed herein are classifiers built on said biomarkers and methods of detecting the disease state in samples from subjects.

Abstract: Gene delivery vectors, such as, for example, recombinant adeno-associated viral vectors, and methods of using such vectors are provided for use in treating or preventing diseases of the eye.

Abstract: A domain name server (DNS) system for processing domain name requests includes a query mechanism constructed and adapted to obtain a user request for response information corresponding to a particular domain name; and provide complete response information in a single response to the user request. The user request may be a domain name resolution request and the query mechanism provides an Internet Protocol (IP) address corresponding to the domain name. A different response may be provided, depending on context information. The system may include an Internet protocol processor and an underlying database repository. The system incorporates a database layout and associated database query strategy that may comprise multiple components which significantly reduces the transaction processing time and overhead as compared to conventional implementations.

Abstract: The present invention describes novel methods that measure in a mammal the level of at least one biomarker, such as a protein and/or mRNA transcript. Based on the level of at least one biomarker in a mammal exposed to a test compound, compared to the level of the biomarker(s) in a mammal that has not been exposed to a test compound, the ability of the test compound to inhibit tyrosine kinase activity can be determined. The invention also relates to novel methods, wherein a change in the level of at least one biomarker in a mammal exposed to a compound, compared to the level of the biomarker(s) in a mammal that has not been exposed to the compound, indicates whether the mammal is being exposed to, or is experiencing or will experience a therapeutic or toxic effect in response to, a compound that inhibit tyrosine kinase activity.

Abstract: Gene delivery vectors, such as, for example, recombinant adeno-associated viral vectors, and methods of using such vectors are provided for use in treating or preventing diseases of the eye.