Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: A system and method for providing awareness in a hospitality environment are presented. In one embodiment, a vertical and horizontal array of set-top boxes is provided and each set-top box includes an identification corresponding to the room in which the set-top box is placed. Each set-top box includes a wireless transceiver that periodically transmits an identification beacon that is received by a proximate wireless-enabled interactive device. The proximate wireless-enabled interactive device, in turn, broadcasts data packets including an indication of the strength of set-top box identification signals received. The broadcasts are received by a server via an array of wireless routers. The location of the proximate wireless-enabled interactive device is determined based on the signal strength information in the data packets.

Abstract: A boat comprises a hull, a primary steering mechanism carried by the hull, a control station located on the hull, a helm located at the control station, and a thruster system carried by the hull. The primary steering mechanism, such as a rudder, is operable via the helm with a helm input being derived from operation of the primary steering mechanism thereby. The thruster system includes at least one thruster mounted to the hull, distinct from the primary steering mechanism, and a controller. The controller receives the helm input and is configured with program instructions to operate the at least one thruster responsive to the helm input to supplement a corresponding movement of the hull. The controller can also automatically operate the thruster responsive to direction, speed and ballast inputs.

Abstract: A geolocationing system and method for providing awareness in a multi-space environment, such as a hospitality environment or educational environment, are presented. In one embodiment of the geolocationing system, a vertical and horizontal array of gateway devices is provided. Each gateway device includes a gateway device identification providing an accurately-known fixed location within the multi-space environment. Each gateway device includes a wireless transceiver that receives a beacon signal from a proximate wireless-enabled personal locator device. The gateway devices, in turn, send gateway signals to a server, which determines estimated location of the wireless-enabled personal locator device.

Abstract: A hospitality property management tool and system and method for use of the same are disclosed. In one embodiment of the system, thermostats are located in respective rooms at a hospitality establishment. The thermostats are joined in network communication with environmental amenities, such as lights and a thermostat that respectively controls lighting and temperature. The thermostats utilize an unoccupied room profile and an occupied room profile to set the environmental conditions, such as the lighting and the temperature, in the rooms. A guest preference profile may be activated within a room to provide guest-specific environmental conditions in the room associated with a guest.

Abstract: A geolocationing system and method for providing awareness in a multi-space environment, such as a hospitality environment or educational environment, are presented. In one embodiment of the geolocationing system, a vertical and horizontal array of gateway devices is provided. Each gateway device includes a gateway device identification providing an accurately-known fixed location within the multi-space environment. Each gateway device includes a wireless transceiver that receives a beacon signal from a proximate wireless-enabled personal locator device. The gateway devices, in turn, send gateway signals to a server, which determines estimated location of the wireless-enabled personal location device with trilateration and received signal strength modeling.

Abstract: A set-top box with self-monitoring and system and method for use of the same are disclosed. In one embodiment of the set-top box, a housing secures a television input, a television output, a processor, memory, and storage therein, which are communicatively interconnected by a busing architecture. The memory is accessible to the processor, and the memory includes processor-executable instructions that, when executed, cause the processor to detect when the television is not being utilized. Responsive thereto, the instructions cause the processor to scan channels received from the television input and generate a composite TV screen image data that may be resolved to a single TV screen image made from an assemblage of TV screen image captures corresponding to the scanned channels.

Abstract: A system for transferring heat from an ethanol and water vapor stream is disclosed as having a first heat exchanger, a valve system coupled to first heat exchanger and a first tank, a second tank coupled to the valve system, a second heat exchanger coupled to first tank and second tank, and a pipe line connecting the second tank to the first heat exchanger. A method for transferring heat is provided and involves intermittently cooling a first media, transferring heat from the first media to a second media, and directing the second media to a valve system. The valve system directs a flow of the second media to the first tank when a temperature of second media is above a temperature set point and directs the flow of the second media to the second tank when the temperature of second media is below the temperature set point.

Abstract: A wagering game system and its operations are described herein. In some embodiments, the operations can include obtaining a mathematical expression(s) from a configuration file associated with a wagering game. The mathematical expression(s) include elements that represent game-related parameters of the one or more wagering games. In some embodiments, the operations further comprise converting the mathematical expression(s) to a programming code expression(s) equivalent to the mathematical expression(s) in response to detection of user-input to configure the wagering game for use via a wagering game machine. In some embodiments, the operations further comprise evaluating the programming code expression(s) using values for the one or more game-related parameters, and configuring the one or more wagering games based on evaluation of the programming code expression(s) using the values for the one or more game-related parameters.

Abstract: A wagering game system and its operations are described herein. In some embodiments, the operations can include obtaining a mathematical expression(s) from a configuration file associated with a wagering game. The mathematical expression(s) include elements that represent game-related parameters of the one or more wagering games. In some embodiments, the operations further comprise converting the mathematical expression(s) to a programming code expression(s) equivalent to the mathematical expression(s) in response to detection of user-input to configure the wagering game for use via a wagering game machine. In some embodiments, the operations further comprise evaluating the programming code expression(s) using values for the one or more game-related parameters, and configuring the one or more wagering games based on evaluation of the programming code expression(s) using the values for the one or more game-related parameters.

Abstract: An automobile trunk compartmentalizer which provides for variable connection of shafts and shaft housings by use of lockable pins whereby great variety of compartment sizes and shapes is possible at the user's option. Creation of more than one row of compartments in the automobile trunk may provide shallow compartments which are desirable for an aging population.

Abstract: A livestock and material inventory system having a database storing inventory data, at least one data explorer operable to access predetermined portions of data in the database, and a graphical user interface operable to display data accessed by the at least one data explorer to a user is provided. The graphical user interface includes a first window operable to display a hierarchical tree structure representation of the inventory data, and a second window operable to display a data summary associated with a selected node in the hierarchical tree structure.

Abstract: An automobile trunk compartmentalizer which provides for variable connection of shafts and shaft housings by use of lockable pins whereby great variety of compartment sizes and shapes is possible at the user's option. Creation of more than one row of compartments in the automobile trunk may provide shallow compartments which are desirable for an aging population.

Abstract: A process for drawing, with plug assist, thin walled, closed-ended, tubular articles of thermoplastic elastomer is disclosed as well as a thermoplastic elastomer and apparatus therefor. According to the process, a plug, extensible into the mold cavity, is employed concurrently with a varying air pressure differential across the faces of the preform to bias the flow of the drawn article axially along the length of the tubular mold and away from the mold walls. At a point where the article is drawn substantially the length of the tubular mold, the mold is evacuated and the article finally formed against the mold walls. Such articles are usefully employed as condoms or finger cots.

Abstract: An expansible core shaft assembly adapted to retain a set of web spool cores in axially fixed positions while permitting rotational slippage of the web spool cores. The assembly may comprise a shaft defining at least one channel. An expansible bladder is retained in the channel and a set of first lugs and a set of second lugs are retained in the channel radially outwardly of the expansible bladder with first and second lugs mutually interspersed. Each lug has a bladder facing surface defining an indentation. The first lugs define a first indentation in a first position and the second lugs define a second indentation that is sufficiently distinct from said first position to reduce the effect that the radial position of each core stop has on the radial positions of its neighbors.

Abstract: A process for drawing, with plug assist, thin walled, closed-ended, tubular articles of thermoplastic elastomer is disclosed as well as a thermoplastic elastomer and apparatus therefor. According to the process, a plug, extensible into the mold cavity, is employed concurrently with a varying air pressure differential across the faces of the preform to bias the flow of the drawn article axially along the length of the tubular mold and away from the mold walls. At a point where the article is drawn substantially the length of the tubular mold, the mold is evacuated and the article finally formed against the mold walls. Such articles are usefully employed as condoms or finger cots.

Abstract: A process for drawing, with plug assist, thin walled, closed-ended, tubular articles of thermoplastic elastomer is disclosed as well as a thermoplastic elastomer and apparatus therefor. According to the process, a plug, extensible into the mold cavity, is employed concurrently with a varying air pressure differential across the faces of the preform to bias the flow of the drawn article axially along the length of the tubular mold and away from the mold walls. At a point where the article is drawn substantially the length of the tubular mold, the mold is evacuated and the article finally formed against the mold walls. Such articles are usefully employed as condoms or finger cots.

Abstract: A computer cooling system provides a more efficient means of cooling, resulting in lower average temperatures and better reliability for the system. It comprises of a rotating baffle or set of baffles, and a formed enclosure. The enclosure accepts cooling fluid in a direction that is parallel to one of its walls. The enclosure is such that a recirculating airflow pattern is set up in its cavity. As the baffle rotates the direction of fluid flow reverses itself in the cavity of the enclosure. The turbulence created by such a system greatly enhances the rate of heat transfer on the components within the enclosure. The exact dimensions of the baffle, and frequency with which it oscillates will depend on the specific system.

Abstract: A hermetic electronic assembly incorporating cryogenically-cooled and air-cooled elements in an integrated assembly. A hermetic cryogenically-cooled enclosure is disposed in close physical proximity to one or more air-cooled circuit cards to minimize physical separation, thereby optimizing signal bandwidth and noise immunity. The air-cooled circuit cards, which generate substantial heat but do not require low operating temperatures, are thermally decoupled from the cryogenically-cooled elements to optimize cryo-cooler efficiency by reserving cooling capacity for the temperature-sensitive processor elements mounted within an evacuated hermetic enclosure. Thus, thermal isolation and physical/electrical proximity are preserved in the same package.