Abstract: An ergonomic holding assist device for endoscopes comprises an attachment mechanism to removably secure the hand assist device to an endoscope. An ergonomic component comfortably fills a space made between a naturally extended palm and the grip portion of the endoscope. A center plate sandwiched between the attachment mechanism and the ergonomic component provides an approximate ½-inch clearance to a top of the device so that the ergonomic component reaches a thenar crease of the palm more comfortably. The flexor tendon of the thumb is comfortably supported by the ergonomic component so that endoscope-work-related injuries are avoided.