Abstract: Disclosed herein are antigen-binding molecules, such as antibodies, that specifically recognize a portion of the EGFR C-terminal (intracellular) regulatory domain that interacts with one or more regulatory molecules (such as Suppressor of Cytokine Signaling (“SOCS”) proteins). In certain normal or neoplastic cells and/or tissues, this region is inaccessible to the disclosed antigen-binding molecules. Thus, such antigen-binding molecules are useful at least to interrogate the regulated state of EGFR, predict the response of a cancer patient to EGFR inhibitor therapies, and/or predict the aggressiveness of neoplasms.

Abstract: Disclosed herein are methods for identifying diagnostic reagents (e.g., antigen-binding molecules, such as antibodies) that are useful, for instance, as primary diagnostic, prognostic, and/or predictive (e.g., companion diagnostic) reagents in a disease state, such as cancer.

Abstract: Disclosed herein are antigen-binding molecules, such as antibodies, that specifically recognize a portion of the EGFR C-terminal (intracellular) regulatory domain that interacts with one or more regulatory molecules (such as Suppressor of Cytokine Signaling (“SOCS”) proteins). In certain normal or neoplastic cells and/or tissues, this region is inaccessible to the disclosed antigen-binding molecules. Thus, such antigen-binding molecules are useful at least to interrogate the regulated state of EGFR, predict the response of a cancer patient to EGFR inhibitor therapies, and/or predict the aggressiveness of neoplasms.

Abstract: The described embodiments relate to data security. One exemplary system includes a first component associated with data on which an action can be performed and a second component configured to perform the action on the data. The system also includes a third component configured to ascertain the action and determine, as a function of the action, at least one policy to be implemented prior to allowing the second component to access the data.

Abstract: Disclosed herein are antigen-binding molecules, such as antibodies, that specifically recognize a portion of the EGFR C-terminal (intracellular) regulatory domain that interacts with one or more regulatory molecules (such as Suppressor of Cytokine Signaling (“SOCS”) proteins). In certain normal or neoplastic cells and/or tissues, this region is inaccessible to the disclosed antigen-binding molecules. Thus, such antigen-binding molecules are useful at least to interrogate the regulated state of EGFR, predict the response of a cancer patient to EGFR inhibitor therapies, and/or predict the aggressiveness of neoplasms.

Abstract: In accordance with certain aspects of the present invention, an algorithm is provided that can be used to detect and track the difference between an on-host clock (i.e., “host clock”) and a remote clock (i.e., “reference clock”). As part of the algorithm, a scaling value is computed and tracked over time. The scaling value, when applied to the host clock, results in clock values that increase at substantially the same rate as the reference clock itself increases. Hence, the host clock will have been slaved to the reference clock.

Abstract: The modification of timestamps of streams of data packets for seamless branching is disclosed. In one aspect of the invention, a computerized system has a plurality of multimedia play devices, and a multimedia read device. Each play device receives and plays data intended for that device. The multimedia read device reads a stream of packets of data, decodes the packets into data, and sends the data to a corresponding play device at appropriate times. The appropriate time is based on relative timestamps accounting for accumulated time gaps resulting from branches within the stream. The invention has applications including digital video disc (DVD) playback.

Abstract: In accordance with certain aspects of the present invention, an algorithm is provided that can be used to detect and track the difference between an on-host clock (i.e., “host clock”) and a remote clock (i.e., “reference clock”). As part of the algorithm, a scaling value is computed and tracked over time. The scaling value, when applied to the host clock, results in clock values that increase at substantially the same rate as the reference clock itself increases. Hence, the host clock will have been slaved to the reference clock.

Abstract: A circuit interrupter manually opens and closes its contacts by use of a manually rotatable handle which acts through a collapsible linkage rotatably connected to a crank extension of the handle and rotatably connected to a rotatably movable contact support. The rotatable contact support is urged away from closed contact position by a main spring and in moving from one contact position to the other the axis of the rotatable connection between the handle crank passes over a center line defined by the center of rotation of the handle and the rotatable connection between the linkage and the movable contact support providing a toggle action to hold the movable contact in selected open or closed position. Upon overload, the mechanism causes collapse of the collapsible linkage allowing the movable contact support to move and open the contacts.