Patents by Inventor William C. Rose

William C. Rose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7132554
    Abstract: This invention relates to a synergistic therapeutic combination of anti-cancer compounds which comprises a) a taxane, and b) a substance that binds to the epidermal growth factor receptor (EGFR) and blocks the ability of epidermal growth factor (EGF) to intitiate receptor activities which results in tumor growth inhibition, and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: November 7, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventor: William C. Rose
  • Publication number: 20040143004
    Abstract: A metronomic dosing regime for taxanes is provided which inhibits tumor growth in animals.
    Type: Application
    Filed: March 1, 2004
    Publication date: July 22, 2004
    Inventors: Joseph Fargnoli, William C Rose, Pamela Trail
  • Patent number: 6750246
    Abstract: The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations. The invention claims compounds of formula I and the use of compounds of formula I or pharmaceutical salts thereof as oral drugs for the treatment of human or veterinary disease. in which: R is phenyl, isopropyl, or tert butyl; R1 is —C(O)Rz in which Rz is (CH3)3CO—, (CH3)3CCH2—, CH3(CH2)3O—, cyclobutyl-, cyclohexyloxy, or (2-furyl); R2 is CH3C(O)O—.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: June 15, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: John F. Kadow, Harold Mastalerz, Qiufen May Xue, Steven Hansel, Mary Edson Zoeckler, William C. Rose, James G. Tarrant
  • Patent number: 5626746
    Abstract: A polishing filter having the capabilities for removing small solids and hydrocarbons present within a liquid flow is a filtration device to be used either in conjunction with processes already in existence or as a stand-alone unit. The polishing filter can be used for marine, commercial or industrial activities. Small solids will be discriminated hi( size by a removable and replaceable bag filter. Residing inside the bag filter is the polishing filter bonding media, a hydrocarbon encapsulation agent used to separate and bond emulsified and dissolved oils. This bonding media is contained inside a porous membrane bag which is also removable and replaceable. The .addition of this device to already existing equipment utilized by ocean vessels and commercial and industrial activities will enhance the decontamination process and assist in compliance with local, national and international clean water laws for effluent from ships and shore-based activities.
    Type: Grant
    Filed: July 25, 1995
    Date of Patent: May 6, 1997
    Inventor: William C. Rose
  • Patent number: 5626748
    Abstract: This invention relates to waste water treatment, more specifically this invention relates to transportable decontamination system for water which is pumped from manholes and equipment vaults. The separation of water and contaminants is accomplished by a five module system. The first module removes 98% of the solids from the waste stream by use of staggered baffles. Module two reclamates the free oil present in the liquid flow with an coalescing water oil separator. The third module removes solids still left in the stream which are greater than 20 microns by use of a size discriminating filter. The fourth and fifth modules are bonding tanks used to encapsulate hydrocarbons and heavy metals respectively. The sequence in which the contaminated flow enters each of the modules is essential to the effectiveness and efficiency of the filtration process.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: May 6, 1997
    Inventor: William C. Rose