Patents by Inventor William C. Swope
William C. Swope has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10392470Abstract: Amphiphilic star polymers were prepared having superior loading properties for delivery of hydrophobic biologically active materials intended for use in medical, cosmetic, and other applications. The star polymers comprise a plurality block copolymer arms linked to a crosslinked polyester core. The monovalent arms comprise a peripheral poly(ethylene oxide) block (PEG block) and a polyester block, which is linked to the core. The sidechain substituents of the polyester block substantially improve the loading capacity of the star polymer for CoQ10 and other hydrophobic materials.Type: GrantFiled: October 26, 2016Date of Patent: August 27, 2019Assignee: International Business Machines CorporationInventors: Robert D. Miller, Victoria A. Piunova, William C. Swope
-
Publication number: 20180112033Abstract: Amphiphilic star polymers were prepared having superior loading properties for delivery of hydrophobic biologically active materials intended for use in medical, cosmetic, and other applications. The star polymers comprise a plurality block copolymer arms linked to a crosslinked polyester core. The monovalent arms comprise a peripheral poly(ethylene oxide) block (PEG block) and a polyester block, which is linked to the core. The sidechain substituents of the polyester block substantially improve the loading capacity of the star polymer for CoQ10 and other hydrophobic materials.Type: ApplicationFiled: October 26, 2016Publication date: April 26, 2018Inventors: Robert D. Miller, Victoria A. Piunova, William C. Swope
-
Patent number: 8805622Abstract: A field-based similarity search system includes an input device which inputs a query molecule, and a processor which partitions a conformational space of the query molecule into a fragment graph including an acyclic graph including plural fragment nodes connected by rotatable bond edges, computes a property field on fragment pairs of fragments of the query molecule from the fragment graph, the property field including a local approximation of a property field of the query molecule, constructs a set of features of the fragment pairs based on the property field, the features including a set of local, rotationally invariant, and moment-based descriptors generated from all conformations of the fragment graph of the query molecule, and weights the descriptors according to importance as perceived from a training set of descriptors to generate a context-adapted descriptor-to-key mapping which maps the set of descriptors to a set of feature keys.Type: GrantFiled: August 29, 2012Date of Patent: August 12, 2014Assignee: International Business Machines CorporationInventors: Michael C. Pitman, Blake G. Fitch, Hans W. Horn, Wolfgang Huber, Julia E. Rice, William C. Swope
-
Patent number: 8793231Abstract: Methods, systems, and articles of manufacture for indexing annotations made for a variety of different type (i.e., heterogeneous) data objects are provided. A set of parameters uniquely identifying an annotated data object may be converted to an index comprising a set of index values, each corresponding to a column in a homogeneous index table. In order to accommodate the indexing of heterogeneous data objects, a mapping may be provided for each different type (or classification) of data object that may be annotated, that defines how the identifying parameters of that type will be mapped to the columns of the homogeneous index table.Type: GrantFiled: August 3, 2007Date of Patent: July 29, 2014Assignee: International Business Machines CorporationInventors: Brian J. Cragun, Julia E. Rice, Peter M. Schwarz, William C. Swope, Hoa T. Tran
-
Publication number: 20140052755Abstract: A field-based similarity search system includes an input device which inputs a query molecule, and a processor which partitions a conformational space of the query molecule into a fragment graph including an acyclic graph including plural fragment nodes connected by rotatable bond edges, computes a property field on fragment pairs of fragments of the query molecule from the fragment graph, the property field including a local approximation of a property field of the query molecule, constructs a set of features of the fragment pairs based on the property field, the features including a set of local, rotationally invariant, and moment-based descriptors generated from all conformations of the fragment graph of the query molecule, and weights the descriptors according to importance as perceived from a training set of descriptors to generate a context-adapted descriptor-to-key mapping which maps the set of descriptors to a set of feature keys.Type: ApplicationFiled: October 17, 2013Publication date: February 20, 2014Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Michael C. Pitman, Blake G. Fitch, Hans W. Horn, Wolfgang Huber, Julia E. Rice, William C. Swope
-
Publication number: 20130036120Abstract: A field-based similarity search system includes an input device which inputs a query molecule, and a processor which partitions a conformational space of the query molecule into a fragment graph including an acyclic graph including plural fragment nodes connected by rotatable bond edges, computes a property field on fragment pairs of fragments of the query molecule from the fragment graph, the property field including a local approximation of a property field of the query molecule, constructs a set of features of the fragment pairs based on the property field, the features including a set of local, rotationally invariant, and moment-based descriptors generated from all conformations of the fragment graph of the query molecule, and weights the descriptors according to importance as perceived from a training set of descriptors to generate a context-adapted descriptor-to-key mapping which maps the set of descriptors to a set of feature keys.Type: ApplicationFiled: August 29, 2012Publication date: February 7, 2013Applicant: International Business Machines CorporationInventors: Michael C. Pitman, Blake G. Fitch, Hans W. Horn, Wolfgang Huber, Julia E. Rice, William C. Swope
-
Patent number: 8321470Abstract: Methods, systems, and articles of manufacture for indexing annotations made for a variety of different type (i.e., heterogeneous) data objects are provided. A set of parameters uniquely identifying an annotated data object may be converted to an index comprising a set of index values, each corresponding to a column in a homogeneous index table. In order to accommodate the indexing of heterogeneous data objects, a mapping may be provided for each different type (or classification) of data object that may be annotated, that defines how the identifying parameters of that type will be mapped to the columns of the homogeneous index table.Type: GrantFiled: June 20, 2003Date of Patent: November 27, 2012Assignee: International Business Machines CorporationInventors: Brian J. Cragun, Julia E. Rice, Peter M. Schwarz, William C. Swope, Hoa T. Tran
-
Patent number: 8306755Abstract: A similarity search method includes generating a feature database which stores data pertaining to a candidate molecule, as executed by a processor of a computer, the database including a hash table having entries which are generated based on, a set of descriptors generated from conformations of fragment graphs of the candidate molecule, the fragment graphs including plural fragment nodes connected by rotatable bond edges, a specific conformation of the fragment node including a fragment of the candidate molecule, and two neighboring fragments connected by a rotatable bond at a specific dihedral angle including a fragment pair, and a context-adapted descriptor-to-key mapping which maps the set of descriptors to a set of feature keys including indices that label grid cells in discriminant space.Type: GrantFiled: May 23, 2011Date of Patent: November 6, 2012Assignee: International Business Machines CorporationInventors: Michael C. Pitman, Blake G. Fitch, Hans W. Horn, Wolfgang Huber, Julia E. Rice, William C. Swope
-
Publication number: 20110225148Abstract: A similarity search method includes generating a feature database which stores data pertaining to a candidate molecule, as executed by a processor of a computer, the database including a hash table having entries which are generated based on, a set of descriptors generated from conformations of fragment graphs of the candidate molecule, the fragment graphs including plural fragment nodes connected by rotatable bond edges, a specific conformation of the fragment node including a fragment of the candidate molecule, and two neighboring fragments connected by a rotatable bond at a specific dihedral angle including a fragment pair, and a context-adapted descriptor-to-key mapping which maps the set of descriptors to a set of feature keys including indices that label grid cells in discriminant space.Type: ApplicationFiled: May 23, 2011Publication date: September 15, 2011Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Michael C. Pitman, Blake G. Fitch, Hans W. Horn, Wolfgang Huber, Julia E. Rice, William C. Swope
-
Patent number: 8014990Abstract: A field-based similarity search system and method includes a database for storing at least one candidate molecule, an input device for inputting a query molecule, and a processor for identifying a candidate molecule which is similar to the query molecule based on a similarity of fragment pair features.Type: GrantFiled: August 20, 2009Date of Patent: September 6, 2011Assignee: International Business Machines CorporationInventors: Michael C. Pitman, Blake G. Fitch, Hans W. Horn, Wolfgang Huber, Julia E. Rice, William C. Swope
-
Publication number: 20100057797Abstract: A field-based similarity search system and method includes a database for storing at least one candidate molecule, an input device for inputting a query molecule, and a processor for identifying a candidate molecule which is similar to the query molecule based on a similarity of fragment pair features.Type: ApplicationFiled: August 20, 2009Publication date: March 4, 2010Applicant: International Business Machines CorporationInventors: Michael C. Pitman, Blake G. Fitch, Hans W. Horn, Wolfgang Huber, Julia E. Rice, William C. Swope
-
Publication number: 20030009298Abstract: A field-based similarity search system and method includes a database for storing at least one candidate molecule, an input device for inputting a query molecule, and a processor for identifying a candidate molecule which is similar to the query molecule based on a similarity of fragment pair features.Type: ApplicationFiled: March 22, 2002Publication date: January 9, 2003Applicant: International Business Machines CorporationInventors: Michael C. Pitman, Blake G. Fitch, Hans W. Horn, Wolfgang Huber, Julia E. Rice, William C. Swope