Abstract: A bioreactor device includes a solid substrate having a first face and a second face. The solid substrate at least partially defines a perfusion channel, a plurality of chambers, a fluidic inlet, and a fluidic outlet. A first sheet disposed over the first face and a second sheet disposed over the second face. Characteristically, the combination of the solid substrate, the first sheet and the second sheet define the perfusion channel and each chamber of the plurality of chambers. The plurality of chambers are arranged in rows of chambers in which adjacent chambers are positioned at opposite side of the perfusion channel. The perfusion channel extends from the fluidic inlet and the fluidic outlet having a serpentine path along each row of chambers with each chamber being in fluid communication with the perfusion channel.

Abstract: An apparatus and method for measuring a biosignal of a monitored patient, processing the measured biosignal to generate a treatment protocol for guiding clinical care of the monitored patient, and outputting the treatment protocol for use by a clinical caregiver. In one example, the monitored patient is a preterm infant, the biosignal is a respiratory pattern of the infant during oral feeding, and the treatment protocol provides a recommended treatment regimen setting forth therapeutic interventions and/or medical interventions for a clinical caregiver to follow for achieving a predetermined outcome for improving oral feeding of the monitored infant.

Abstract: Various embodiments are disclosed of universal actuators for an imaging device or probe. The universal actuator may move the imaging device or probe in one or more of a horizontal direction, vertical direction, rotational directions (e.g., axial rotation and pivoting motions). In some embodiments, the universal actuator is configured to mount to a conventional slit lamp microscope to aid in visualizing the face and or eye(s) of a subject. In other embodiments, the universal actuator is hand-held and is used to scan an imaging probe (e.g., ultrasound probe) over the surface of an eye. The universal actuator may also be removable or separable from a base that is mounted to a slit lamp microscope allowing for both instrument-based scanning and manual scanning via the hand-held device. The imaging device or imaging probe is used to obtain 2D image data. In some embodiments this 2D data is then used to generate 3D images of, for example, the face or eye(s).

Abstract: A recharging system for recharging batteries or providing power to an implantable device includes an electric coil adapted to be coupled to the implantable device, the electric coil defining a coil interior and a coil exterior. A magnetic component is coupled to the electric coil and adapted to at least partially surround the implantable device. A mechanical actuator is attached to the magnetic component, the mechanical actuator converting compression motion into motion of the magnetic component relative to the electric coil.

Abstract: A bioreactor device includes a solid substrate having a first face and a second face. The solid substrate at least partially defines a perfusion channel, a plurality of chambers, a fluidic inlet, and a fluidic outlet. A first sheet disposed over the first face and a second sheet disposed over the second face. Characteristically, the combination of the solid substrate, the first sheet and the second sheet define the perfusion channel and each chamber of the plurality of chambers. The plurality of chambers are arranged in rows of chambers in which adjacent chambers are positioned at opposite side of the perfusion channel. The perfusion channel extends from the fluidic inlet and the fluidic outlet having a serpentine path along each row of chambers with each chamber being in fluid communication with the perfusion channel.

Abstract: A recharging system for recharging batteries or providing power to an implantable device includes an electric coil adapted to be coupled to the implantable device, the electric coil defining a coil interior and a coil exterior. A magnetic component is coupled to the electric coil and adapted to at least partially surround the implantable device. A mechanical actuator is attached to the magnetic component, the mechanical actuator converting compression motion into motion of the magnetic component relative to the electric coil.

Abstract: A multielectrode array with a fluidic channel and its method of fabrication are presented here. In accordance with various embodiments, the present invention allows for scalability, reproducibility, and precision dimension control by utilizing a lithography dependent process. In one embodiment, the present invention provides for a microelectrode that is a neural implant, with the microelectrode configured for connection to a fluidic channel. In another embodiment, the fluidic channel may deliver growth factors and/or drugs.

Abstract: A multielectrode array with a fluidic channel and its method of fabrication are presented here. In accordance with various embodiments, the present invention allows for scalability, reproducibility, and precision dimension control by utilizing a lithography dependent process. In one embodiment, the present invention provides for a microelectrode that is a neural implant, with the microelectrode configured for connection to a fluidic channel. In another embodiment, the fluidic channel may deliver growth factors and/or drugs.

Abstract: A device for identifying infection by the malaria parasite includes a microfluidic device having an inlet and an outlet and a diagnostic channel interposed between the inlet and the outlet. The diagnostic channel includes a contact surface and a sample pump configured to pump a RBC-containing sample into the inlet. The contact surface may be at least one of hydrophilic and roughened. Malaria infected RBCs (miRBCs) interact with the contact surface and become immobilized thereon whereas non-infected RBCs continue to flow downstream in the diagnostic channel.

Abstract: A neural probe device includes a housing configured to receive a nerve fiber of a subject and an anchor disposed within the housing and configured to fix the nerve fiber relative to the housing. The device further includes a plurality of actuatable, moveable electrodes disposed in the housing along a length of the nerve fiber, each moveable electrode comprising a plurality of projections containing one or more electrodes thereon, wherein actuation of the moveable electrode causes the moveable electrode to move generally transverse to a long axis of the nerve fiber and penetrate the nerve fiber with the plurality of projections. The device is also optionally configured to inject a growth factor into the nerve fiber to maintain the viability of the nerve fiber.

Abstract: A neural probe device includes a housing configured to receive a nerve fiber of a subject and an anchor disposed within the housing and configured to fix the nerve fiber relative to the housing. The device further includes a plurality of actuatable, moveable electrodes disposed in the housing along a length of the nerve fiber, each moveable electrode comprising a plurality of projections containing one or more electrodes thereon, wherein actuation of the moveable electrode causes the moveable electrode to move generally transverse to a long axis of the nerve fiber and penetrate the nerve fiber with the plurality of projections. The device is also optionally configured to inject a growth factor into the nerve fiber to maintain the viability of the nerve fiber.

Abstract: A device for identifying infection by the malaria parasite includes a microfluidic device having an inlet and an outlet and a diagnostic channel interposed between the inlet and the outlet. The diagnostic channel includes a contact surface and a sample pump configured to pump a RBC-containing sample into the inlet. The contact surface may be at least one of hydrophilic and roughened. Malaria infected RBCs (miRBCs) interact with the contact surface and become immobilized thereon whereas non-infected RBCs continue to flow downstream in the diagnostic channel.

Abstract: Devices, systems and methods that comprise or utilize implantable electrode arrays for neural stimulation and/or sensing. In some embodiments, the electrode array is implanted or inserted into the auditory nerve and is used to deliver electrical impulses to/receive data from the auditory nerve in the treatment of hearing disorders.

Abstract: A capacitive accelerometer includes electrode plates supported and aligned for movement in the direction of a substrate in which they are supported. Preferably, the plates are formed a surface micro machining, and each plate includes capacitor forming surfaces aligned at an acute angle with respect to each other. In addition, each capacitive accelerometer is formed as a differential capacitor so that one movable plate is disposed between to relatively stationary plates and a plurality of stationary and movable plates are aligned in a series along a portion of the substrate. The suspension comprises a cantilevered support arrangement for the plates.

Abstract: A digital capacitive accelerometer is disclosed as having a fixed plate mounted on a support member and a sprung plate resiliently mounted in spaced relationship to the fixed plate to form a capacitor. A voltage is connected across the plates to establish an electrostatic force that pulls the sprung plate toward the fixed plate. The voltage is incrementally increased, pulling the sprung plate incrementally toward the fixed plate. When a pull-in voltage level is reached, the electrostatic force is of sufficient magnitude to abruptly pull the sprung plate across the remaining distance separating it from the fixed plate, and a pull-in detection signal is generated by detecting a current pulse as the gap collapses. The plates are then released, and another incrementing cycle is initiated. The pull-in voltage is a function of the initial capacitor gap which in turn is determined by the acceleration the device is experiencing.

Abstract: A microbridge device for use as a sensor or an actuator is driven parallel to a substrate as a resonant microstructure. The microstructure comprises a stationary thin-film electrode secured to the substrate and located in a plane above it. A movable plate overlaying the substrate is suspended above it. The movable plate and electrode are patterned to provide for each at least one comb with fingers interdigitated with those of the other.