Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: A Knuckle Jointed Lance (KJL), comprising a segmented lance including a plurality of elongate and hollow KJL segments in a concatenated string thereof. The first segment end of one KJL segment is rotatably connected to the second segment end of a neighboring KJL segment via a pinned connection. Neighboring pairs of KJL segments together provide an interlocking toothed connection such that each interlocking toothed connection restrains relative torsional displacement between the neighboring pair of KJL segments. In other embodiments, pinned connections also provide ears, each with cooperating ear ledges and ear ledge recesses to strengthen the pinned connection.

Abstract: A mud screen manifold in which a saver sub chamber, a screen chamber and a mud inlet chamber are formed in a body. A hollow saver sub is provided, suitable for insertion into the saver sub chamber after connection to a screen cage. When a shaped flange on the saver sub is received into a correspondingly shaped recess formed in the saver sub chamber, a mud flow inlet is in fluid flow communication with a cutout in the saver sub via the mud inlet chamber, and the saver sub is in fluid flow communication with the screen chamber via fluid flow through the screen cage. Contact seals prevent fluid flow from leaking around the screen cage. The mud inlet chamber, the saver sub and the saver sub cutout preferably cooperate to form a smooth-walled passageway for fluid flow communication between the mud inlet chamber and the screen cage.

Abstract: A mud screen manifold in which a saver sub chamber, a screen chamber and a mud inlet chamber are formed in a body. A hollow saver sub is provided, suitable for insertion into the saver sub chamber after connection to a screen cage. When a shaped flange on the saver sub is received into a correspondingly shaped recess formed in the saver sub chamber, a mud flow inlet is in fluid flow communication with a cutout in the saver sub via the mud inlet chamber, and the saver sub is in fluid flow communication with the screen chamber via fluid flow through the screen cage. Contact seals prevent fluid flow from leaking around the screen cage. The mud inlet chamber, the saver sub and the saver sub cutout preferably cooperate to form a smooth-walled passageway for fluid flow communication between the mud inlet chamber and the screen cage.

Abstract: A mud screen manifold in which a saver sub chamber, a screen chamber and a mud inlet chamber are formed in a body. A hollow saver sub is provided, suitable for insertion into the saver sub chamber after connection to a screen cage. When a shaped flange on the saver sub is received into a correspondingly shaped recess formed in the saver sub chamber, a mud flow inlet is in fluid flow communication with a cutout in the saver sub via the mud inlet chamber, and the saver sub is in fluid flow communication with the screen chamber via fluid flow through the screen cage. Contact seals prevent fluid flow from leaking around the screen cage. The mud inlet chamber, the saver sub and the saver sub cutout preferably cooperate to form a smooth-walled passageway for fluid flow communication between the mud inlet chamber and the screen cage.

Abstract: A mud screen manifold in which a saver sub chamber, a screen chamber and a mud inlet chamber are formed in a body. A hollow saver sub is provided, suitable for insertion into the saver sub chamber after connection to a screen cage. When a shaped flange on the saver sub is received into a correspondingly shaped recess formed in the saver sub chamber, a mud flow inlet is in fluid flow communication with a cutout in the saver sub via the mud inlet chamber, and the saver sub is in fluid flow communication with the screen chamber via fluid flow through the screen cage. Contact seals prevent fluid flow from leaking around the screen cage. The mud inlet chamber, the saver sub and the saver sub cutout preferably cooperate to form a smooth-walled passageway for fluid flow communication between the mud inlet chamber and the screen cage.

Abstract: Methods are disclosed for performing operations such as cleaning, inspection or data acquisition on an external surface of a hollow cylindrical tubular. Preferred embodiments include providing a fluid dispenser and an abrasion assembly on a buggy that travels up and down the length of the tubular as the tubular rotates. The fluid dispenser includes nozzles that dispense cleaning fluids onto the tubular's external surface. The abrasion assembly includes a swivel brush and a brush train providing different styles of abrasion cleaning of the tubular's external surface. Preferred embodiments include robotically monitoring abrader contact against the external surface of the tubular, and, in response, dynamically adjusting the distance between the external surface of the tubular and the abrasion assembly.

Abstract: A Knuckle Jointed Lance (KJL), comprising a segmented lance including a plurality of elongate and hollow KJL segments in a concatenated string thereof. The first segment end of one KJL segment is rotatably connected to the second segment end of a neighboring KJL segment via a pinned connection. Neighboring pairs of KJL segments together provide an interlocking toothed connection such that each interlocking toothed connection restrains relative torsional displacement between the neighboring pair of KJL segments. In other embodiments, pinned connections also provide ears, each with cooperating ear ledges and ear ledge recesses to strengthen the pinned connection.

Abstract: A Knuckle Jointed Lance (KJL), comprising a segmented lance including a plurality of connected KJL segments in a concatenated string thereof. The first end of one KJL segment is rotatably connected to the second end of a neighboring KJL segment via a pinned connection. Responsive to user assignment of a predetermined length to each KJL segment in the concatenated string according to the KJL segment's corresponding pre-ordained position in the concatenated string, the lance is disposed to spool onto a reel in “nested” fashion, such that as the lance makes spooling revolutions onto the reel, (a) KJL segments stack in circumferential registered layers around the reel and (b) pinned connections trace substantially radial vectors from a center of the reel. Other embodiments provide additional features to facilitate nesting and to generally strengthen the KJL.

Abstract: A data acquisition system for determining the state of a tubular while the tubular rotates about its cylindrical axis. The tubular remains otherwise substantially stationary. Sensors travel up and down the length of the rotating tubular, interrogating the inside and outside of the tubular for data regarding the tubular's state. Sensors may take samples which may be associated with rotational reference information tying the sample to its absolute position on the internal or external surface of the tubular. A data processor processes the samples and other sensor data to produce a wide array of output, including data signatures of the tubular, maps of contour data regarding the internal or external surface of the tubular, and dimensional data regarding the tubular. Data acquisition is advantageously done in real time, and may further be done concurrently with internal or external cleaning operations.

Abstract: Methods are disclosed for performing operations such as cleaning, inspection or data acquisition on an external surface of a hollow cylindrical tubular. Preferred embodiments include providing a fluid dispenser and an abrasion assembly on a buggy that travels up and down the length of the tubular as the tubular rotates. The fluid dispenser includes nozzles that dispense cleaning fluids onto the tubular's external surface. The abrasion assembly includes a swivel brush and a brush train providing different styles of abrasion cleaning of the tubular's external surface. Preferred embodiments include robotically monitoring abrader contact against the external surface of the tubular, and, in response, dynamically adjusting the distance between the external surface of the tubular and the abrasion assembly.

Abstract: A Knuckle Jointed Lance (KJL), comprising a segmented lance including a plurality of connected KJL segments in a concatenated string thereof. The first end of one KJL segment is rotatably connected to the second end of a neighboring KJL segment via a pinned connection. Responsive to user assignment of a predetermined length to each KJL segment in the concatenated string according to the KJL segment's corresponding pre-ordained position in the concatenated string, the lance is disposed to spool onto a reel in “nested” fashion, such that as the lance makes spooling revolutions onto the reel, (a) KJL segments stack in circumferential registered layers around the reel and (b) pinned connections trace substantially radial vectors from a center of the reel. Other embodiments provide additional features to facilitate nesting and to generally strengthen the KJL.

Abstract: A multi-lance reel assembly comprising a plurality of reel assemblies received onto and disposed to rotate about an axle. Each reel assembly rotates independently of the others. Each reel assembly further comprises a plurality of spokes separating a rim from a hub. Each hub provides a hub groove on each internal hub surface, and a hub aperture connecting each external hub surface with the hub groove. When the reel assemblies are received onto the axle, axle grooves on the axle align with the hub grooves to form a continuous ring aperture for each reel assembly. Separate axle apertures connect either one of the end faces of the axle with each axle groove, providing a separate passageway from each external hub surface to an axle end face. Hoses, electrical conduits, conductors or other similar carrier hardware deployed within hollow lances spooled on each reel assembly may connect to the hub apertures.

Abstract: Methods are disclosed for handling cylindrical tubulars in a process that, in preferred embodiments, also performs cleaning, inspection and other operations on the tubular. The tubular is held stationary while it is rotated. During rotation of the tubular, internal and external cleaning systems, and data acquisition systems, pass up and down the length of the rotating tubular. In preferred embodiments, a first tubular is loaded onto the handling machine, whereupon it is indexed and then rotated. Cleaning, inspection and other operations may be performed during rotation. Once operations are complete, the handling system ejects the first tubular while queuing up a second tubular to be loaded.

Abstract: Methods are disclosed for performing operations such as cleaning, inspection or data acquisition on an external surface of a hollow cylindrical tubular. Preferred embodiments include providing a fluid dispenser and an abrasion assembly on a buggy that travels up and down the length of the tubular as the tubular rotates. The fluid dispenser includes nozzles that dispense cleaning fluids onto the tubular's external surface. The abrasion assembly includes a swivel brush and a brush train providing different styles of abrasion cleaning of the tubular's external surface. Preferred embodiments of the buggy also carry a range finding laser generating samples of the distance from the laser to a sampled point on the tubular's external surface. The laser samples are processed in real time into surface contour data. Cleaning and inspection variables such as tubular rotational speed, or buggy speed, may be adjusted responsive to measured surface contour data.

Abstract: Methods are disclosed for performing operations such as cleaning, inspection or data acquisition on an external surface of a hollow cylindrical tubular. Preferred embodiments include providing a fluid dispenser and an abrasion assembly on a buggy that travels up and down the length of the tubular as the tubular rotates. The fluid dispenser includes nozzles that dispense cleaning fluids onto the tubular's external surface. The abrasion assembly includes a swivel brush and a brush train providing different styles of abrasion cleaning of the tubular's external surface. Preferred embodiments of the buggy also carry a range finding laser generating samples of the distance from the laser to a sampled point on the tubular's external surface. The laser samples are processed in real time into surface contour data. Cleaning and inspection variables such as tubular rotational speed, or buggy speed, may be adjusted responsive to measured surface contour data.

Abstract: A knuckle-jointed lance (KJL) segment with an exterior protective system (EPS), comprising an elongated hollow body and at least one protective rod. The body has a generally trapezoidal profile, when viewed in elevation, and is open at both ends. At least one elongate recess is provided in the exterior surface of the body. Each recess follows a predetermined pathway within the exterior surface. At least one consumable protective rod is received into each elongate recess.

Abstract: A single-lance reel assembly comprising a reel assembly received onto and disposed to rotate about an axle at a rotary union. The reel assembly further comprises a plurality of spokes separating a rim from a hub. Hoses, electrical conduits, conductors or other similar carrier hardware deployed within hollow lances spooled on the reel assembly may be supplied via the rotary union and by further hose connection structure deployed on the hub and/or the rim. Embodiments of the reel assembly are powered by either a direct or indirect drive.

Abstract: Enhanced methods are disclosed for handling cylindrical tubulars, advantageously in association with cleaning, inspection and other operations on the tubular. The tubular is held stationary while it is rotated. During rotation of the tubular, internal and external cleaning systems, and data acquisition systems, pass up and down the length of the rotating tubular. In preferred embodiments, a first tubular is loaded onto the handling machine, whereupon it is indexed and then rotated. Cleaning, inspection and other operations may be performed during rotation. Once operations are complete, the handling system ejects the first tubular while queuing up a second tubular to be loaded. The handling machine comprises a plurality of user-positional pods. Each pod includes scissor mechanisms, index machines and a roller machine to perform the handling methods. Sensors on drive rollers in the handling machine generate vibrational response data of the tubular while it rotates.

Abstract: A knuckle jointed lance (KJL) segment with an exterior protective system (EPS), comprising an elongated hollow body and at least one protective rod. The body has a generally trapezoidal profile, when viewed in elevation, and is open at both ends. At least one elongate recess is provided in the exterior surface of the body. Each recess follows a predetermined pathway within the exterior surface. At least one consumable protective rod is received into each elongate recess.