Patents by Inventor William C. Trenkle

William C. Trenkle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrazone and diacyl hydrazine compounds and methods of use
    Patent number: 8518968
    Abstract: Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the p97 ATPase. These agents provide useful tools for the study of protein degradation and other processes involving p97. Methods of treating diseases or disorders for which p97 inhibition and/or ER stress induction is an effective treatment with certain hydrazone and diacyl hydrazine derivatives are also disclosed.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: August 27, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Adrian Wiestner, Yihong Ye, Qiuyan Wang, William C. Trenkle, Bidhan A. Shinkre
  • HYDRAZONE AND DIACYL HYDRAZINE COMPOUNDS AND METHODS OF USE
    Publication number: 20120316198
    Abstract: Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the p97 ATPase. These agents provide useful tools for the study of protein degradation and other processes involving p97. Methods of treating diseases or disorders for which p97 inhibition and/or ER stress induction is an effective treatment with certain hydrazone and diacyl hydrazine derivatives are also disclosed.
    Type: Application
    Filed: December 3, 2010
    Publication date: December 13, 2012
    Applicant: The United States of American, as Represented by the Secretary, Dept. of Health and Human Services
    Inventors: Adrian Wiestner, Yihong Ye, Qiuyan Wang, William C. Trenkle, Bidhan A. Shinkre
  • Method of using rhodium quinonoid catalysts
    Publication number: 20100010235
    Abstract: In accordance with aspects of the invention methods of using rhodium hydroquinone catalysts for the conjugate addition of boronic acids are disclosed.
    Type: Application
    Filed: June 19, 2009
    Publication date: January 14, 2010
    Inventors: William C. Trenkle, Julia L. Barkin, Seung Uk Son, Dwight A. Sweigart, Marcus D. Faust, JR.
  • Method of using rhodium quinonoid catalysts
    Patent number: 7569734
    Abstract: In accordance with aspects of the invention methods of using rhodium hydroquinone catalysts for the conjugate addition of boronic acids are disclosed.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: August 4, 2009
    Assignee: Brown University
    Inventors: William C. Trenkle, Julia L. Barkin, Seung Uk Son, Dwight A. Sweigart, Marcus D. Faust, Jr.
  • Rhodium quinonoid catalysts
    Patent number: 7495097
    Abstract: In accordance with one aspect of the invention a rhodium quinonoid catalyst is disclosed.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: February 24, 2009
    Assignee: Brown University
    Inventors: Dwight A. Sweigart, Seung Uk Son, Jeffrey A. Reingold, William C. Trenkle