Abstract: An improved probe guide and probe guide system for use in conjunction with a medical imaging device is disclosed. The medical imaging device may be any type of imaging device that generates a cross-sectional image of a portion of a patient's body in a single image plane, such as, ultrasound, CT, or MRI imaging devices. The probe guide allows maintaining the movement of the probe within the image plane and accurate placement of a probe, such as a biopsy needle, by allowing a range of angular translation of the probe. The probe guide system enables extrapolation of the penetration path of the probe held by the probe guide and superimpose it on to the cross-sectional image allowing the medical personnel to view the penetration path of the probe within the patient in advance.