Abstract: Compositions and methods are provided for improving the treatment of tumors by inhibiting cytochrome P450 enzymes (“CYPs”) expressed by tumors. Inhibition of tumor-expressed CYPs provides improved dosing of anti-tumor drugs, inhibits development of drug resistance by tumors and provides improved patient outcomes.

Abstract: A rotary tool is disclosed. The rotary tool can include a first arm and a second arm pivotally coupled to one another at a joint. Ends of the first and second arms are positionable at a variable distance from one another by pivoting the first and second arms at the joint. The rotary tool can also include a first rotatable driver disposed at the end of the first arm, a second rotatable driver disposed at the end of the second arm, and a third rotatable driver disposed at the joint. In addition, the rotary tool can include a drive train operably coupled to the first, second, and third rotatable drivers to transfer torque, such that an input torque applied to one of the first, second, and third rotatable drivers causes torque output at the other rotatable drivers.

Abstract: Compositions and methods are provided for improving the treatment of tumors by inhibiting cytochrome P450 enzymes (“CYPs”) expressed by tumors. Inhibition of tumor-expressed CYPs provides improved dosing of anti-tumor drugs, inhibits development of drug resistance by tumors and provides improved patient outcomes.

Abstract: A rotary tool is disclosed. The rotary tool can include a first arm and a second arm pivotally coupled to one another at a joint. Ends of the first and second arms are positionable at a variable distance from one another by pivoting the first and second arms at the joint. The rotary tool can also include a first rotatable driver disposed at the end of the first arm, a second rotatable driver disposed at the end of the second arm, and a third rotatable driver disposed at the joint. In addition, the rotary tool can include a drive train operably coupled to the first, second, and third rotatable drivers to transfer torque, such that an input torque applied to one of the first, second, and third rotatable drivers causes torque output at the other rotatable drivers.

Abstract: A remote antenna deployment latch is disclosed. The remote antenna deployment latch includes a latch assembly having a latch pin movable to alternately secure an antenna in, and release the antenna from, a deployed position. The remote antenna deployment latch also includes an azimuth pin movable to alternately lock and unlock rotation of the antenna about an azimuth axis. In addition, the remote antenna deployment latch includes a remote control assembly operably coupled to the latch pin and the azimuth pin to simultaneously secure the antenna in the deployed position and unlock rotation of the antenna about the azimuth axis.

Abstract: A remote antenna deployment latch is disclosed. The remote antenna deployment latch includes a latch assembly having a latch pin movable to alternately secure an antenna in, and release the antenna from, a deployed position. The remote antenna deployment latch also includes an azimuth pin movable to alternately lock and unlock rotation of the antenna about an azimuth axis. In addition, the remote antenna deployment latch includes a remote control assembly operably coupled to the latch pin and the azimuth pin to simultaneously secure the antenna in the deployed position and unlock rotation of the antenna about the azimuth axis.

Abstract: The present invention extends to methods, systems, and computer program products for synchronizing ambient state among multiple transaction managers. A coordinating transaction manager establishes transaction ambient state for an application initiated transaction. The coordinating transaction manager sends and a subordinate transaction manager receives a pointer to an ambient state delegate. The subordinate transaction manager sends a request to invoke the ambient state delegate to the coordinating transaction manager in response to receiving an operation. The coordinating transaction manager invokes the ambient state delegate to format the transaction ambient state for the subordinate transaction manager. The coordinating transaction manager sends and the subordinate transaction manager receives the formatted transaction ambient state such that the subordinate transaction manager can appropriately process the operation within the scope of the transaction.

Abstract: The present invention extends to methods, systems, data structures, and computer program products for maintaining correct transaction results when transaction management configurations change. An intermediate transaction manager is transparently interposed between one or more resource managers and a plurality of transaction managers. The intermediate transaction manager multiplexes and intercepts calls and notifications between the one or more resource managers and the plurality of transaction managers. The intermediate transaction manager is configured to wrap recovery cookies with transaction manager type information and identity information that identify transaction managers. The information can be used to re-attach to the transaction manager to recover the correct outcome of the transaction. The intermediate transaction manager can also intercept recovery-complete calls directed to a specific transaction manager and send the recovery-complete call to each of the plurality of transaction managers.

Abstract: Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.

Abstract: Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.