Abstract: Methods and compositions are provided for preparing stabilized interferons and for combining stabilized interferon with cigarettes. Special domains of the interferon molecule are recognized by methods which are described. A means for constructing these domains by recombinant DNA technology is detailed. A method for stabilizing natural interferons is also described. A process for combining the stabilized interferon with cigarettes is presented.The combination of interferons and cigarettes is synergistic, especially because interferon effects are magnified at elevated temperatures and because interferon has a preferential effect on tumor cells, but for other reasons as well. The process is not obvious and will be beneficial to a large segment of mankind; those who use tobacco products.

Abstract: A new process for stabilizing purified human interferon is described, using propylene glycol. Propylene glycol also aids in the interferon purification procedure. Older methods used stabilizing agents which are toxic, antigenic or irritating. The new process will make available significantly more interferon of clinical purity for use in patients with cancer, viral illnesses and other diseases as yet undesignated (e.g. multiple sclerosis, amyotropic lateral sclerosis, scleroderma, etc.).

Abstract: An apparatus for electrotreating a metal strip and employing an electrode roll having a metallic outer surface covered by a porous mesh layer composed of electrically non-conductive material and fixedly secured to the outer surface of the electrode roll.

Abstract: An apparatus and method for electro-treating one surface of a metal strip alone or both surfaces sequentially. Another embodiment electro-treats both surfaces simultaneously. All embodiments employ a roll having an electrically conducting outer surface around a substantial portion of which is wrapped the strip. An electrically insulating mesh layer is interposed between the strip and the roll's outer surface, and electrolytic liquid floods the openings in the mesh layer and is retained there by that portion of the strip which is wrapped around the roll. The strip is advanced in a downstream direction, and the roll is simultaneously rotated. The strip and the outer surface of the roll are electrically charged with opposite polarities, but neither one is immersed in a bath of electrolytic liquid. Cations flow between the roll and the wrapped-around portion of the strip through the liquid in the openings of the mesh layer.

Abstract: The present invention relates to the induction of interferon production in the cells of living organisms, including human beings. According to the invention, nucleic acid complexes, such as the polyriboinosinate and polycytidylate complex (rI.sub.n .multidot.rC.sub.n), are modified to yield unpaired bases, (uracil or guanine) along the polycytidylate strand which render the complexes more readily hydrolyzable by nucleases present in living cells. The modified complexes retain their ability to stimulate interferon release by the cells but are rendered more vulnerable to destruction within the cells, the modified complexes being significantly less toxic than the original complexes. In addition, polyinosinate strand now has been prepared to contain 5-16% 2'-O-methyl inosinate residues, designated as (rI.sub.5-20, 2'-MeI).sub.n. The new complex (rI.sub.5-20, 2'-MeI).sub.n .multidot.rC.sub.n, exhibits 100-fold more activity than rI.sub.n .multidot.rC.sub.n as an interferon inducer in human cells.

Abstract: A compressed batt of fibers is fed against a rotating toothed roll for dispersion of the fibers from the batt and this dispersion of fibers is fed through the point of closest clearance between the toothed roll and a feed roll rotating in the opposite direction. Downstream of this point of closest clearance, a stationary shoe is provided spaced from the surface of the toothed roll to permit the dispersion of fibers to follow the surface of the toothed roll. The shoe is closely fitted to the surface of the feed roll which has the effect of forming a pinch point where the feed roll enters beneath the shoe. In accordance with the invention, the shoe is equipped with passages for the flow of air to exit at the pinch point to prevent fibers from entering the pinch point, i.e., between the feed roll and shoe.

Abstract: The present invention relates to the induction of interferon production in the cells of living organisms, including human beings. According to the invention, nucleic acid complexes, such as the polyriboinosinate and polycytidylate complex (rI.sub.n.rC.sub.n), are modified to yield unpaired bases (uracil or guanine) along the polycytidylate strand which render the complexes more readily hydrolyzable by nucleases present in living cells. The modified complexes retain their ability to stimulate interferon release by the cells but are rendered more vulnerable to destruction within the cells, the modified complexes being significantly less toxic than the original complexes. In addition, polyinosinate strand now has been prepared to contain 5-16% 2'-O-methyl inosinate residues, designated as (rI.sub.5-20,2'-MeI).sub.n. The new complex (rI.sub.5-20,2'-MeI).sub.n.rC.sub.n, exhibits 100-fold more activity than rI.sub.n.rC.sub.n as an interferon inducer in human cells.

Abstract: A series of acylphosphonate esters have been found which prevent or relieve some of the ill effects of UV exposure to human skin.

Abstract: Textile fabric previously impregnated with THPOH is treated to retard inflammability by passage therethrough of toxic ammonia gas in apparatus which permits the THPOH--NH.sub.3 reaction to be carried out in a sealed chamber preventing escape of the toxic gas. The invention operates to confine the gas in a flow path whereby substantially all of the gas flowing through the apparatus is passed directly through the fabric. The fabric is passed through the sealed chamber by means of gas-tight entrance and exit portals. A perforated drum is mounted within the chamber and the fabric is passed about the perimeter of the drum. Sealing elements cooperating with the drum confine ammonia gas introduced into the interior of the drum to flow only through those perforations covered by fabric.

Abstract: Textile fabric previously impregnated with THPOH is treated to retard inflammability by passage therethrough of toxic ammonia gas in apparatus which permits the THPOH-NH.sub.3 reaction to be carried out in a sealed chamber preventing escape of the toxic gas. The invention operates to confine the gas in a flow path whereby substantially all of the gas flowing through the apparatus is passed directly through the fabric. The fabric is passed through the sealed chamber by means of gas-tight entrance and exit portals. A perforated drum is mounted within the chamber and the fabric is passed about the perimeter of the drum. Sealing elements cooperating with the drum confine ammonia gas introduced into the interior of the drum to flow only through those perforations covered by fabric.