Abstract: A spectral imaging device (1312) for capturing one or more, two-dimensional, spectral images (1313A) of a sample (1310) including (i) an image sensor (1328), (ii) an illumination source (1314), (iii) a beam path adjuster (1362), and (iv) a control system (1330). The illumination source (1314) that generates an illumination beam (1316) that is directed along an incident sample beam path (1360) at the sample (1310). The beam path adjuster (1362) selectively adjusts the incident sample beam path (1360).

Abstract: A spectral imaging device (1312) for capturing one or more, two-dimensional, spectral images (1313A) of a sample (1310) including (i) an image sensor (1328), (ii) an illumination source (1314), (iii) a beam path adjuster (1362), and (iv) a control system (1330). The illumination source (1314) that generates an illumination beam (1316) that is directed along an incident sample beam path (1360) at the sample (1310). The beam path adjuster (1362) selectively adjusts the incident sample beam path (1360).

Abstract: A system for determining a probability of normal rectal tissue composition within a region of interest of an ultrasound or photoacoustic image of the rectal tissue is disclosed. The system includes a computing device with at least one processor configured to receive at least one of a photoacoustic image and an ultrasound image; select a region of interest within the at least one of a photoacoustic image and an ultrasound image; transform the region of interest into the probability of normal rectal tissue composition using a CNN model; and display the probability of normal rectal tissue composition to an operator of the system.

Abstract: A system and method for perfusing an organ with a normothermic extracorporeal perfusion system is disclosed. The perfusion system is an active flow system using a centrifugal pump to aid in circulation. The system includes a dialyzer that removes excess fluid and impurities, while maintaining the pH, which allows the perfusion system to be used for an extended period that may exceed 24 hours. The system includes a parallel circuit, which includes at least one centrifugal pump, a membrane oxygenator comprising a heat exchanger; a dialyzer; a measurement cell for real-time monitoring of oxygen saturation and hematocrit in the liver; more than one flow probe; and an organ chamber.

Abstract: An assembly (14) for analyzing a sample (15) includes a detector assembly (18); a tunable laser assembly (10); and (iii) a laser controller (10F). The detector assembly (18) has a linear response range (232) with an upper bound (232A) and a lower bound (232B). The tunable laser assembly (10) is tunable over a tunable range, and includes a gain medium (10B) that generates an illumination beam (12) that is directed at the detector assembly (18). The laser controller (10F) dynamically adjusts a laser drive to the gain medium (10B) so that the illumination beam (12) has a substantially constant optical power at the detector assembly (18) while the tunable laser assembly (10) is tuned over at least a portion of the tunable range.

Abstract: A spectral imaging device (12) for generating an image (13A) of a sample (10) includes (i) an image sensor (30); (ii) a tunable light source (14) that generates an illumination beam (16) that is directed at the sample (10); (iii) an optical assembly (22) that collects light from the sample (10) and forms an image of the sample (10) on the image sensor (30); and (iv) a control system (32) that controls the tunable light source (14) and the image sensor (30). During a time segment, the control system (32) (i) controls the tunable light source (14) so that the illumination beam (16) has a center wavenumber that is modulated through a first target wavenumber with a first modulation rate; and (ii) controls the image sensor (30) to capture at least one first image at a first frame rate. Further, the first modulation rate is equal to or greater than the first frame rate.

Abstract: A spectral imaging device (12) includes an image sensor (28), an illumination source (14), a refractive, optical element (24A), a mover assembly (24C) (29), and a control system (30). The image sensor (28) acquires data to construct a two-dimensional spectral image (13A) during a data acquisition time (346). The illumination source (14) generates an illumination beam (16) that illuminates the sample (10) to create a modified beam (16I) that follows a beam path (16B) from the sample (10) to the image sensor (28). During the data acquisition time (346), the control system (30) controls the illumination source (14) to generate the illumination beam (16), and controls the image sensor (28) to capture the data. Further, during the data acquisition time (346), an effective optical path segment (45) of the beam path (16B) is modulated.

Abstract: An assembly (14) for analyzing a sample (15) includes a detector assembly (18); a tunable laser assembly (10); and (iii) a laser controller (10F). The detector assembly (18) has a linear response range (232) with an upper bound (232A) and a lower bound (232B). The tunable laser assembly (10) is tunable over a tunable range, and includes a gain medium (10B) that generates an illumination beam (12) that is directed at the detector assembly (18). The laser controller (10F) dynamically adjusts a laser drive to the gain medium (10B) so that the illumination beam (12) has a substantially constant optical power at the detector assembly (18) while the tunable laser assembly (10) is tuned over at least a portion of the tunable range.

Abstract: A spectral imaging device (12) includes an image sensor (28), an illumination source (14), a refractive, optical element (24A), a mover assembly (24C) (29), and a control system (30). The image sensor (28) acquires data to construct a two-dimensional spectral image (13A) during a data acquisition time (346). The illumination source (14) generates an illumination beam (16) that illuminates the sample (10) to create a modified beam (16I) that follows a beam path (16B) from the sample (10) to the image sensor (28). During the data acquisition time (346), the control system (30) controls the illumination source (14) to generate the illumination beam (16), and controls the image sensor (28) to capture the data. Further, during the data acquisition time (346), an effective optical path segment (45) of the beam path (16B) is modulated.

Abstract: A spectral imaging device (12) includes an image sensor (28), an illumination source (14), a refractive, optical element (24A), a mover assembly (24C) (29), and a control system (30). The image sensor (28) acquires data to construct a two-dimensional spectral image (13A) during a data acquisition time (346). The illumination source (14) generates an illumination beam (16) that illuminates the sample (10) to create a modified beam (16I) that follow a beam path (16B) from the sample (10) to the image sensor (28). The refractive, optical element (24A) is spaced apart a separation distance (42) from the sample (10) along the beam path (16B). During the data acquisition time (346), the control system (30) controls the illumination source (14) to generate the illumination beam (16), controls the mover assembly (29) (24C) to modulate the separation distance (42), and controls the image sensor (28) to capture the data.

Abstract: A spectral imaging device (12) for generating an image (13A) of a sample (10) includes (i) an image sensor (30); (ii) a tunable light source (14) that generates an illumination beam (16) that is directed at the sample (10); (iii) an optical assembly (22) that collects light from the sample (10) and forms an image of the sample (10) on the image sensor (30); and (iv) a control system (32) that controls the tunable light source (14) and the image sensor (30). During a time segment, the control system (32) (i) controls the tunable light source (14) so that the illumination beam (16) has a center wavenumber that is modulated through a first target wavenumber with a first modulation rate; and (ii) controls the image sensor (30) to capture at least one first image at a first frame rate. Further, the first modulation rate is equal to or greater than the first frame rate.

Abstract: A system and method for perfusing an organ with a normothermic extracorporeal perfusion system is disclosed. The perfusion system is an active flow system using a centrifugal pump to aid in circulation. The system includes a dialyzer that removes excess fluid and impurities, while maintaining the pH, which allows the perfusion system to be used for an extended period that may exceed 24 hours. The system includes a parallel circuit, which includes at least one centrifugal pump, a membrane oxygenator comprising a heat exchanger; a dialyzer; a measurement cell for real-time monitoring of oxygen saturation and hematocrit in the liver; more than one flow probe; and an organ chamber.

Abstract: A spectral imaging device (12) includes an image sensor (28), an illumination source (14), a refractive, optical element (24A), a mover assembly (24C) (29), and a control system (30). The image sensor (28) acquires data to construct a two-dimensional spectral image (13A) during a data acquisition time (346). The illumination source (14) generates an illumination beam (16) that illuminates the sample (10) to create a modified beam (16I) that follow a beam path (16B) from the sample (10) to the image sensor (28). The refractive, optical element (24A) is spaced apart a separation distance (42) from the sample (10) along the beam path (16B). During the data acquisition time (346), the control system (30) controls the illumination source (14) to generate the illumination beam (16), controls the mover assembly (29) (24C) to modulate the separation distance (42), and controls the image sensor (28) to capture the data.

Abstract: An analysis assembly (12) for analyzing one or more physiological parameters of a person (10) comprises a sensor assembly (14) and an analyzer (16). The sensor assembly (14) includes a sampler (218) that collects a sample (220) from the person (10); and a signal generating apparatus (222) that directs a mid-infrared light beam (232) toward the sample (220) and performs spectroscopy on the sample (220) to generate a signal (215) that is based at least in part on the one or more physiological parameters of the person (10). The sampler (218) and the signal generating apparatus (222) can be positioned less than approximately one meter from the person (10) while the sample (220) is being collected and spectroscopically scanned to generate the signal (215). The analyzer (16) receives and analyzes the signal (215) to determine the presence of the one or more physiological parameters in the sample (220).

Abstract: A sensor system for sensing the presence of methane and sulfur hexafluoride in an area includes (i) a laser assembly including a quantum cascade gain medium that generates a MIR output beam that is directed at the area; and (ii) an imager that captures a thermal image of the area when the MIR output beam is generated. To sense the presence of methane, the MIR output beam has a center wavelength that is in the range of between approximately 7.654 and 7.668 microns. Alternatively, to sense the presence of sulfur hexafluoride, the MIR output beam has a center wavelength that is in the range of between approximately 10.56 and 10.58 microns.

Abstract: One or more flapper valve assemblies are placed in a casing string extending through one or more hydrocarbon bearing intervals. The flapper valve assemblies are placed between some of the hydrocarbon bearing intervals. In an open or inoperative position, the flapper valve assemblies are full opening compared to the casing string. The hydrocarbon bearing intervals are stimulated, typically by fracing, starting with the bottom zone. The flapper valve assembly immediately above the stimulated interval is manipulated to allow it to close, preventing downward flow in the well and thereby isolating the lower stimulated interval so an upper interval can be stimulated. The well is easy to put on production because the flapper valves will normally open simply by opening the well at the surface.

Abstract: A dispending bottle having an open top closed by a cap with a stopper-type drinking valve, and two separate compartments or chambers in upper and lower sections of the bottle joined together by a rotary coupler permitting twisting of the top and bottom sections in opposite direction to open a mixing valve in the mid portion of the bottle. Spiral ribs facilitate gripping and twisting, and flexible walls facilitate mixing.

Abstract: A method and apparatus for the transmission of multiple control characters of the same type to a receiver to improve the retention of transmitter to receiver synchronization in a noisy environment having receiver code that is less complex and does not require an increase in the bandwidth of the system since the control codes are already utilized to initiate other functions. Detection of any of the control characters of the same type by the receiver allows the receiver to maintain proper synchronization. The receiver will detect these control signals and anticipate the occurrence of an event within a predetermined time period.