Abstract: A method of treating or preventing motion sickness is disclosed which comprises administering an anti-motion sickness effective amount of an anticonvulsant compound such as phenytoin, ethotoin, primidone, ethosuximide or carbamazepine, in combination with a potentiating amount of an antitussive or cough suppressant agent such as dextromethorphan, levopropoxyphene, muscaphene, pholocodeine, or carbetapentene. The antitussive compounds of the present invention act as potentiating agents so as to enable effective treatment or prevention of motion sickness using a reduced amount of the anticonvulsant compound normally used in such treatment. The method of the present invention reduces the potential for various side effects and thus provides a safer and more effective method of treatment for motion sickness than prior art methods.

Abstract: Certain anticonvulsant drugs have been found to be effective in the treatment of motion sickness. These compounds have the structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are H, aliphatic or aromatic groups;B is --C.dbd.O or --CH.sub.2 --;n is 0 or 1;X is ##STR2## and their non-toxic, pharmaceutically-acceptable acid addition salt.

Abstract: Certain anticonvulsant drugs have been found to be effective in the treatment of motion sickness. These compounds have the structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are H, aliphatic or aromatic groups;B is --C.dbd.O or --CH.sub.2 --;n' is 0 or 1;n" is 0 or 1; andX is ##STR2## with the further proviso that when n' is 1, n" is also 1, and their non-toxic, pharmaceutically acceptable acid addition salts.