Abstract: The present disclosure relates to indolinyl compounds. The present disclosure further relates to compounds that inhibit viral helicase-primase. The present disclosure further relates to the use of the compounds for the preparation a medicament for the treatment of diseases and/or condition through inhibiting viral helicase-primase. The present disclosure also relates to use of those compounds in the treatment of viral infections. The present disclosure further relates to intermediates for its preparation and to pharmaceutical compositions containing those compounds.

Abstract: A method for providing localized treatment at a target site in the brain of a patient is provided. The method comprises providing a system comprising a miniature device configured to carry one or more therapeutic components for performing the treatment, and an external system configured to direct the miniature device; inserting the miniature device to a starting location within the patient; operating the external system to direct the miniature device to travel along an access path from the starting location to the target site; and administering the therapeutic component at the target site. A system for performing the method is further provided.

Abstract: Provided herein is an intervention tool and a method for fracturing multiple lateral wellbores in a well system. The intervention tool, in one aspect, includes a radial outer housing, the radial outer housing forming an interior bore configured to flow fluid, and an expansion member coupled proximate an outer surface of the radial outer housing. The intervention tool according to this aspect further includes a sliding sleeve positioned along an interior surface of the radial outer housing and engageable with the expansion member, the sleeve including a collection of slots or catches configured to move the expansion member between a radially retracted position when the sliding sleeve is in a first linear position and a radially expanded position when the sliding sleeve is in a second linear position.

Abstract: A main well bore is drilled. The main well bore is completed and stimulated. The main well bore is sealed. A lateral well bore is drilled off the main well bore. A junction that allows communication with the lateral well bore and that connects the main well bore is inserted. The lateral well bore is stimulated through the junction. The main well bore is unsealed, allowing comingled flow from the main bore and the lateral bore.

Abstract: Provided, in one aspect, is a deflector assembly. The deflector assembly, in one embodiment, includes a deflector body having a deflector window located therein, and a deflector ramp positioned at least partially across the deflector window, the deflector ramp configured to move between first ({circle around (1)}), second ({circle around (2)}) and third ({circle around (3)}) different positions when a downhole tool moves back and forth within the deflector body.

Abstract: A lid for a vacuum sealing device may include a housing that supports a sealing station. The housing may define a sealing surface with a sealing perimeter that is able to seal against a canister body when the sealing surface is located on the canister body so that the sealing surface and the canister body together define a sealed volume. The sealing station is supported by the housing and extends from the housing. The sealing station is configured to heat seal an open bag, the sealing station being located within the sealing perimeter of the sealing surface such that when the lid is located onto the canister body, the sealing station is disposed within the sealed volume. The lid may have an internal pump for vacuum sealing operations or may receive a vacuum from an external source.

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided.

Abstract: A gravel pack flow path used to flow slurry fluids during a gravel pack phase may be closed or at least limited with a swellable metallic material prior to a production phase. An example apparatus may include a base pipe, a screen disposed about the base pipe, an inflow control device having an ICD flow path in fluid communication with an outer annulus between the screen and base pipe. The gravel pack flow path defined in part by perforations in a base pipe or by a secondary housing. A swellable metallic material is activated to close the gravel pack flow path in response to a reactive fluid.

Abstract: A gravel pack flow path used to flow slurry fluids during a gravel pack phase may be closed or at least limited with a swellable metallic material prior to a production phase. An example apparatus may include a base pipe, a screen disposed about the base pipe, an inflow control device having an ICD flow path in fluid communication with an outer annulus between the screen and base pipe. The gravel pack flow path defined in part by perforations in a base pipe or by a secondary housing. A swellable metallic material is activated to close the gravel pack flow path in response to a reactive fluid.

Abstract: A main well bore is drilled. The main well bore is completed and stimulated. The main well bore is sealed. A lateral well bore is drilled off the main well bore. A junction that allows communication with the lateral well bore and that connects the main well bore is inserted. The lateral well bore is stimulated through the junction. The main well bore is unsealed, allowing comingled flow from the main bore and the lateral bore.

Abstract: The disclosed embodiments include multilateral completion systems and methods to deploy multilateral completion systems. A multilateral completion system includes a main bore completion having an inductive coupler, a lateral completion having an inductive coupler, and a second lateral completion also having an inductive coupler. The multilateral completion system also includes a junction having an inductive coupler, and a second junction having an inductive coupler.

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided.

Abstract: Provided, in one aspect, is a deflector assembly. The deflector assembly, in one embodiment, includes a deflector body having a deflector window located therein, and a deflector ramp positioned at least partially across the deflector window, the deflector ramp configured to move between first ({circle around (1)}), second ({circle around (2)}) and third ({circle around (3)}) different positions when a downhole tool moves back and forth within the deflector body.

Abstract: Provided herein is an intervention tool and a method for fracturing multiple lateral wellbores in a well system. The intervention tool, in one aspect, includes a radial outer housing, the radial outer housing forming an interior bore configured to flow fluid, and an expansion member coupled proximate an outer surface of the radial outer housing. The intervention tool according to this aspect further includes a sliding sleeve positioned along an interior surface of the radial outer housing and engageable with the expansion member, the sleeve including a collection of slots or catches configured to move the expansion member between a radially retracted position when the sliding sleeve is in a first linear position and a radially expanded position when the sliding sleeve is in a second linear position.

Abstract: Apparatuses, systems and methods are provided for determining vehicle driver distractions. More particularly, apparatuses, systems and methods are provided for determining distractions associated with vehicle driving routes based on postures of vehicle occupants.

Abstract: Apparatuses, systems and methods are provided for determining vehicle driver distractions. More particularly, apparatuses, systems and methods are provided for determining distractions associated with vehicle driving routes based on postures of vehicle occupants.

Abstract: Apparatuses, systems and methods are provided for determining vehicle driver distractions. More particularly, apparatuses, systems and methods are provided for determining distractions associated with vehicle driving routes based on postures of vehicle occupants.

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided.

Abstract: Embodiments of the present invention include techniques for charging a battery. In one embodiment, the present invention includes a method comprising determining if a maximum current output of a power source is above a threshold, configuring a regulator coupled to the power source, wherein the regulator is configured in a pass mode if the maximum current output is above the threshold, and wherein the regulator is configured in a regulation mode if the maximum current output is below the threshold, and generating pulses to a battery, wherein an output of the regulator is coupled to the battery when a pulse is being generated, and the output of the regulator is decoupled from the battery when a pulse is not being generated. In other embodiments, the techniques may be embodied in a circuit including a detection circuit and a switching regulator coupled to a battery through a pulse circuit.

Abstract: A pressure relief system including a container having (a) at least two layers sealed together to form a closed cavity and (b) a stress point area is disclosed. The stress point area is configured to rupture upon sufficient pressure being generated in the closed cavity so that venting of pressurized contents of the container cavity may occur without explosive bursting of the container.