Abstract: A breathing assistance apparatus has a housing with an engagement feature and an electrical component in the housing and a removable component. The electrical component has a receptacle. The removable component has an electrical connector that is a close or tight fit in the receptacle of the electrical component to assist with holding the removable component in connection with the electrical component. The removable component has a tab with a terminal end portion that can be flexed relative to the rest of the removable component. An engagement feature is provided on the terminal end portion of the tab and engages with the engagement feature of the housing to inhibit disconnection of the removable component from the housing in the absence of actuating the terminal end portion of the removable component to flex the tab.

Abstract: A sequence of polymer units in a polymer (3), eg. DNA, is estimated from at least one series of measurements related to the polymer, eg. ion current as a function of translocation through a nanopore (1), wherein the value of each measurement is dependent on a k-mer being a group of k polymer units (4). A probabilistic model, especially a hidden Markov model (HMM), is provided, comprising, for a set of possible k-mers: transition weightings representing the chances of transitions from origin k-mers to destination k-mers; and emission weightings in respect of each k-mer that represent the chances of observing given values of measurements for that k-mer. The series of measurements is analysed using an analytical technique, eg. Viterbi decoding, that refers to the model and estimates at least one estimated sequence of polymer units in the polymer based on the likelihood predicted by the model of the series of measurements being produced by sequences of polymer units.

Abstract: The present disclosure relates to a composition that includes a first copolymer having a first repeat unit and a second repeat unit as defined by Structure (I) where is a covalent bond, U1 is a molar fraction of the first repeat unit, (1?U1) is a molar fraction of the second repeat unit, 0?n?20, 0?m?20, 0<U1?1.0, R is a linking group covalently linking the first copolymer to a second copolymer by the covalent bond, and R includes carbon, hydrogen, and sulfur.

Abstract: The invention provides a dosing system for an inhalation device, comprising a filling chamber (10); a reservoir chamber (31) which supplies liquid (3) to an aerosol generator (301); and a plunger (20) which includes an overflow chamber (25) and which is pivotable about a hinge (50). The filling chamber has an inner wall (12) which is higher on the side adjacent to the hinge than on the opposite side. When the filling chamber is filled with liquid and the plunger is pivoted into the filling chamber, part of the liquid is displaced over the lower side (17) of the inner wall into the reservoir chamber and some or all of the remaining liquid is displaced into the overflow chamber. The invention also provides an inhalation device comprising the dosing system and a method for dosing liquid to the inhalation device.

Abstract: An indicator device comprises an indicator member (102, 222, 330) moveable between first and second positions, a switch means (152, 252, 352) engageable by the indicator member when the indicator member is in the second position, a signal generating means (160, 260, 360) for generating a data signal, connected to the switch means, a signal transmitting means (158, 258, 358) connected to the signal generating means for wirelessly transmitting the data signal and an electrical power source (162, 262, 362) for supplying electrical power to the signal generating means and the signal transmitting means, wherein the device is configured to generate and transmit a data signal on actuation of the switch means. The invention also includes a dispensing device comprising such an indicator device.

Abstract: Described herein are methods and systems for the weight estimation of commercial vehicles and using these estimates to control different vehicle systems such as powertrain, brakes, and suspension. A vehicle comprises a weight estimator, which receives input from different vehicle systems and/or sensors (e.g., suspension, powertrain, speedometer, tire pressure monitoring system) and uses these inputs to determine weight values associated with the vehicle (e.g., total weight, weight distribution per axle, weight distribution per wheel, load distribution). These weight values are then used by the power train, brakes, and/or suspension as additional input for operating these systems besides drivers' input, e.g., provided as pedal positions. For example, different weight values can cause different powertrain outputs for the same accelerator pedal position, e.g., greater output for a heavier vehicle. As such, a driver experiences more uniform vehicle responses for different vehicle loads.

Abstract: Described herein are systems and methods for using different truck types for deliveries. A package is initially loaded into a specially configured cargo container that can be transported either on a primary truck or a secondary truck. A secondary truck is smaller than a primary truck and is configured to transport fewer cargo containers than the primary truck. An initial leg of the overall delivery (e.g., from a warehouse to a transfer point) is performed using a primary truck. The cargo container is then transferred to a secondary truck, which completes the delivery. Empty cargo containers can be transferred back to a primary truck, e.g., in a stacked or folded manner, for transporting back to the warehouse. The configurations of primary and secondary trucks are such that these transfers can occur at any location (e.g., a parking lot) with minimal human involvement.

Abstract: Described herein are methods and systems for estimating the current weight of commercial vehicles. A system comprising a weight estimator, which receives input from one or more vehicle systems and/or sensors, such as suspension, power train, speedometer, tire pressure monitoring system, and the like. The weight estimator uses these inputs to determine one or more weight values associated with the vehicle, such as the total vehicle weight, weight distribution per axle, weight distribution per wheel, load distribution, and the like. In some examples, the weight estimator submits these weight values to one or more other systems. For example, the weight values may be used as an indicator that the vehicle is overloaded and/or that the weight is distributed unevenly. In some examples, the weight values are used by a maintenance scheduler to determine the next required maintenance.

Abstract: Described herein are systems and methods for using different truck types for deliveries. A package is initially loaded into a specially configured cargo container that can be transported either on a primary truck or a secondary truck. A secondary truck is smaller than a primary truck and is configured to transport fewer cargo containers than the primary truck. An initial leg of the overall delivery (e.g., from a warehouse to a transfer point) is performed using a primary truck. The cargo container is then transferred to a secondary truck, which completes the delivery. Empty cargo containers can be transferred back to a primary truck, e.g., in a stacked or folded manner, for transporting back to the warehouse. The configurations of primary and secondary trucks are such that these transfers can occur at any location (e.g., a parking lot) with minimal human involvement.

Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.

Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.

Abstract: An indicator device comprises an indicator member (102, 222, 330) moveable between first and second positions, a switch means (152, 252, 352) engageable by the indicator member when the indicator member is in the second position, a signal generating means (160, 260, 360) for generating a data signal, connected to the switch means, a signal transmitting means (158, 258, 358) connected to the signal generating means for wirelessly transmitting the data signal and an electrical power source (162, 262, 362) for supplying electrical power to the signal generating means and the signal transmitting means, wherein the device is configured to generate and transmit a data signal on actuation of the switch means. The invention also includes a dispensing device comprising such an indicator device.

Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.

Abstract: The invention provides a dosing system for an inhalation device, comprising a filling chamber (10); a reservoir chamber (31) which supplies liquid (3) to an aerosol generator (301); and a plunger (20) which includes an overflow chamber (25) and which is pivotable about a hinge (50). The filling chamber has an inner wall (12) which is higher on the side adjacent to the hinge than on the opposite side. When the filling chamber is filled with liquid and the plunger is pivoted into the filling chamber, part of the liquid is displaced over the lower side (17) of the inner wall into the reservoir chamber and some or all of the remaining liquid is displaced into the overflow chamber. The invention also provides an inhalation device comprising the dosing system and a method for dosing liquid to the inhalation device.

Abstract: A dispensing device comprises a loading chamber (12), a dispensing chamber (14), located beneath the loading chamber, a gate or shutter (24) movable between a first open position and a second closed position to allow selective communication of the loading chamber and the dispensing chamber. The device further comprises a first indicating means in the form of a first indicator member (114) which is retainable in a first-retracted position when the gate or shutter (24) is in the closed position and which is displaceable to a second, extended position when the gate or shutter is moved from the closed position to the open position. The device further comprises second indicating means (116) which is actuable to display a second visible signal to indicate that the first signal has been observed.

Abstract: Methods for cleaning a superalloy substrate having engine deposits on its surface are provided. The method may include applying a permanganate solution onto the surface of the superalloy substrate, and applying a ferric chloride based cleaning composition onto the surface of the superalloy substrate. The ferric chloride based cleaning composition includes ferric chloride and at least one of nitric acid and phosphoric acid, such as within a solvent system (e.g., an aqueous solution including water).

Abstract: Recombinantly expressed variant antibodies that have enhanced affinity for TL1A and enhanced potency relative to the parent antibody from which they were derived are provided. The antibodies inhibit the interaction between TL1A and the death receptor 3 (DR3). The antibodies, or a composition thereof, may be used to treat one or more of asthma, COPD, pulmonary fibrosis, cystic fibrosis, inflammatory bowel disease, a gastrointestinal disease associated with cystic fibrosis, Crohn's disease, colitis, ulcerative colitis, irritable bowel syndrome, eosinophilic esophagitis, atopic dermatitis, eczema, scleroderma, arthritis, or rheumatoid arthritis.

Abstract: Methods for cleaning a superalloy substrate having engine deposits on its surface are provided. The method may include applying a permanganate solution onto the surface of the superalloy substrate, and applying a ferric chloride based cleaning composition onto the surface of the superalloy substrate. The ferric chloride based cleaning composition includes ferric chloride and at least one of nitric acid and phosphoric acid, such as within a solvent system (e.g., an aqueous solution including water).