Abstract: The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: The invention provides certain quinolines and aza-quinolines of the Formula (I), and their pharmaceutically acceptable salts, wherein E, J1, Ja, Jb, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for data storage. In one aspect, a method includes the actions of identifying a running query from an application; determining one or more data items of a plurality of data items that the application has permission to view according to one or more application specific access policies; and presenting the one or more data items to the application while not presenting other data items of the plurality of data items.

Abstract: The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative ?-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.

Abstract: The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: The invention provides certain quinolines and aza-quinolines of the Formula (I), and their pharmaceutically acceptable salts, wherein E, J1, Ja, Jb, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of A?42 and hence are useful in treatment of Alzheimer's disease and related conditions.

Abstract: The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative ?-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for data storage. In one aspect, a method includes the actions of identifying a running query from an application; determining one or more data items of a plurality of data items that the application has permission to view according to one or more application specific access policies; and presenting the one or more data items to the application while not presenting other data items of the plurality of data items.

Abstract: According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of A?42 and hence are useful in treatment of Alzheimer's disease and related conditions.

Abstract: A dental floss dispenser cap for attachment to a toothpaste tube. The dental floss dispenser cap according to certain embodiments of the invention, comprises a housing and an annular base. Upstanding walls form a cylindrical protrusion and a cavity dimensioned to receive the cap of a toothpaste tube underneath. A spool of floss may be placed on the cylindrical protrusion for rotation and dispensing. A cover may be attached to the housing by a first hinge. The cover preferably comprises a notch opening for the dental floss to pass through and a metal cutting member such as a lance mounted to the cover. A lid may be attached to the cover by a second hinge. The lid can be opened and closed to access the dental floss and protect it from contamination when not in use as desired.

Abstract: A vehicle body-and-frame-alignment apparatus for use in realigning the front inner structures of damaged unitized or unibody constructed vehicles employing sliding strut-shock units as front-end suspension systems, wherein the apparatus is formed by a substantially rectangular adjustable frame gauge defined by upper and lower horizontal gauge bars adjustably interconnected to oppositely positioned vertical side gauge bars by coupling brackets, each gauge bar including a measuring tape disposed along the longitudinal length thereof. The frame gauge is adapted to be supported on the sliding strut-shock units by an adjustable pair of gauge-positioning members slidably mounted to the upper horizontal bar, the lower horizontal bar being provided with a fixed central indicator and a second pair of gauge-positioning members, each gauge-positioning member including a vertically adjustable reference pointer to indicate structural alignment or misalignment of the vehicle structure.

Abstract: A vehicle body-and-frame-alignment apparatus for use in realigning the front inner structures of damaged unitized or unibody constructed vehicles employing sliding strut-shock units as front-end suspension systems, wherein the apparatus is formed by a substantially rectangular adjustable frame gauge defined by upper and lower horizontal gauge bars adjustably interconnected to oppositely positioned vertical side gauge bars by coupling brackets, each gauge bar including a measuring tape disposed along the longitudinal length thereof. The frame gauge is adapted to be supported on the sliding strut-shock units by an adjustable pair of gauge-positioning members slidably mounted to the upper horizontal bar, the lower horizontal bar being provided with a fixed central indicator and a second pair of gauge-positioning members, each gauge-positioning member including a vertically adjustable reference pointer to indicate structural alignment or misalignment of the vehicle structure.