Abstract: A method of delivering exosomes and other micro vesicles to a biological target includes the steps of 1) providing blood, (2) separating plasma from the provided blood, and (3) separating the solution with the exosomes therefrom, (4) encapsulating the exosomes, and (5) delivering the exosomes. The step of encapsulation may be accomplished by water bead process, alginate bead process, spray drying bead formation, or plating. The biological target may be a human or animal heart, bone/joint, wound or skin. A method of encapsulating an exosome, a method of using an encapsulated exosome, compositions including encapsulated exosomes, and an encapsulated exosome per se are also disclosed.

Abstract: A method of delivering exosomes and other micro vesicles to a biological target includes the steps of 1) providing blood, (2) separating plasma from the provided blood, and (3) separating the solution with the exosomes therefrom, (4) encapsulating the exosomes, and (5) delivering the exosomes. The step of encapsulation may be accomplished by water bead process, alginate bead process, spray drying bead formation, or plating. The biological target may be a human or animal heart, bone/joint, wound or skin. A method of encapsulating an exosome, a method of using an encapsulated exosome, compositions including encapsulated exosomes, and an encapsulated exosome per se are also disclosed.

Abstract: Described herein is a high performance mouthguard. Generally, the mouthguard includes a base that includes at least one facial wall, at least one lingual structure extending from the base such that the base, the facial wall, and the lingual structure define a trough having an inner surface, a heat-softenable material disposed in the inner surface, defining a channel, and at least one protrusion that includes a heat-softenable material projecting into the channel from the heat-softenable material disposed on the inner surface of at least one of the at least one facial wall and the at least one lingual structure.

Abstract: Described herein is a high performance mouthguard. Generally, the mouthguard includes a tray formed from a non-softenable material. The tray generally includes an arched wall comprising a top, a bottom, a lingual surface, and a facial surface and, in addition to the arched wall, at least one generally vertical recess in at least a portion of the lingual surface. The mouthguard further includes a generally arched trough formed from a heat-softenable material. Generally, the trough includes an arched t wall comprising a lingual surface and a facial surface. Moreover, the trough includes at least one member protruding from the facial surface that is positioned and shaped to fit within the at least one recess of the tray.

Abstract: Embodiments relate to an interchangeable mouthguard component system. The system includes a mouthguard base with a receiving recess positioned within at least a front surface of the base, a securely attachable mouthguard component positioned to fit within the recess, one or more attaching posts positioned on one of the recess or component and one or more holes positioned opposite the posts on either the recess or component. The mouthguard component, when attached, is positioned sufficient to maintain a substantially flush front surface of the base.

Abstract: A dental appliance is disclosed herein. The dental appliance, in various aspects, includes arms disposed about occlusal pad to secure the dental appliance in a removable fashion to the teeth of the user. The occlusal pad is formed from an occlusal pad material transformable between a pliable state and a non-pliable state, in various aspects. Associated methods of use are also disclosed herein.

Abstract: A dental appliance, related methods of manufacture, and compositions of matter are disclosed herein. In various aspects, the dental appliance may include material layers bonded to one another. The bond between the material layers may be formed, at least in part, by interdigitation of the material layers with one another. Methods of forming the interdigitation are disclosed herein. Compositions of matter that may include interdigitated material layers are disclosed herein.

Abstract: A mouthguard apparatus is disclosed herein. In various aspects, the mouthguard apparatus includes an electronics package adapted to attach removably to a dental appliance. The dental appliance may be configured to be secured within the mouth of a user. At least portions of the electronics package adapted to extend external to a mouth of the user when the electronics package is attached to the dental appliance and the dental appliance is secured within the mouth of the user, in various aspects. Related methods are disclosed herein. This Abstract is presented to meet requirements of 37 C.F.R. §1.72(b) only. This Abstract is not intended to identify key elements of the apparatus and methods disclosed herein or to delineate the scope thereof.

Abstract: Systems and methods for searching for objects located in a virtual world include having a virtual construct such as a bot crawl the virtual world by moving from place to place. Object information is collected about the objects associated with the place and the object information is stored in a searchable database. Users can search the database for objects in the virtual world. The information can be further filtered or classified to aid in searching.

Abstract: Systems and methods for searching for objects located in a virtual world include having a virtual construct such as a bot crawl the virtual world by moving from place to place. Object information is collected about the objects associated with the place and the object information is stored in a searchable database. Users can search the database for objects in the virtual world. The information can be further filtered or classified to aid in searching.

Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

Abstract: Systems and methods for searching for objects located in a virtual world include having a virtual construct such as a bot crawl the virtual world by moving from place to place. Object information is collected about the objects associated with the place and the object information is stored in a searchable database. Users can search the database for objects in the virtual world. The information can be further filtered or classified to aid in searching.

Abstract: An RFID tag is configured to contain identification information in at least three forms. For instance, the RFID tag may include an RFID system, and a human readable number and a bar code that may be visible on an outer surface of the RFID tag. The RFID system, the human readable number and the bar code may generate the same asset identification number. The RFID tag may also be formed from two or more layers having a thickness sufficient to substantially eliminate interference caused by a shipping container to which the RFID tag is attached.

Abstract: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: A system for anchoring an endoluminal prosthesis comprises a barb. The barb comprises a base, a retractable body extending distally from the base towards a distal anchor, and a hinge disposed between the base and the anchor and spaced apart from the base. The anchor pivots about the hinge between a retracted configuration and an extended configuration. Additional devices, systems, and methods are disclosed.

Abstract: A classifier for classifying particulates entrained in a flowing stream of gas is configured such that a change of direction of gas flow causes particles to impinge upon a target, heavier particles being trapped in a downwardly extending fluidized trap. The classifier is easily constructed, has no moving parts, and can take the place of sifters and other equipment traditionally used for classifying such product streams.