Patents by Inventor William Crago

William Crago has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DR5 Agonist and PLK1 Inhibitor or CDK Inhibitor Combination Therapy
    Publication number: 20250215101
    Abstract: Provided herein are methods of treating cancer with a combination of a DR5 agonist and a PLK1 inhibitor. Also provided herein are methods of treating cancer with a combination of a DR5 agonist and a CDK inhibitor.
    Type: Application
    Filed: April 7, 2023
    Publication date: July 3, 2025
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: William Crago, Brendan P. Eckelman, Katelyn M. Willis
  • OX40-binding polypeptides and uses thereof
    Patent number: 12331126
    Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.
    Type: Grant
    Filed: May 8, 2024
    Date of Patent: June 17, 2025
    Assignee: Inhibrx Biosciences, Inc.
    Inventors: John C. Timmer, William Crago, Kyle Jones, Katelyn Willis, Florian Sulzmaier, Bryan Becklund, Brendan P. Eckelman
  • NKp46-Binding Polypeptides and Uses Thereof
    Publication number: 20250136681
    Abstract: Provided herein are VHH-containing polypeptides that bind NKp46. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: August 29, 2022
    Publication date: May 1, 2025
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: John C. Timmer, Brendan P. Eckelman, Rajay A. Pandit, William Crago, Florian Sulzmaier, Heather Kinkead, Nadja Kern
  • CD33-Binding Polypeptides and Uses Thereof
    Publication number: 20250059279
    Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: August 2, 2024
    Publication date: February 20, 2025
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: Kyle S. Jones, William Crago, Angelica Sanabria, Andrew Hollands, Jacob Gano, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • OX40-Binding Polypeptides and Uses Thereof
    Publication number: 20240409651
    Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: May 8, 2024
    Publication date: December 12, 2024
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: John C. Timmer, William Crago, Kyle Jones, Katelyn Willis, Florian Sulzmaier, Bryan Becklund, Brendan P. Eckelman
  • NKp46-Targeted Modified IL-2 Polypeptides and Uses Thereof
    Publication number: 20240376198
    Abstract: Provided herein are NKp46-targeted modified IL-2 polypeptides. Uses of the polypeptides are also provided.
    Type: Application
    Filed: August 29, 2022
    Publication date: November 14, 2024
    Applicant: Inhibrx, Inc.
    Inventors: John C. Timmer, Brendan P. Eckelman, Rajay A. Pandit, William Crago, Florian Sulzmaier, Heather Kinkead, Nadja Kern
  • CD33-binding polypeptides and uses thereof
    Patent number: 12084502
    Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.
    Type: Grant
    Filed: December 16, 2022
    Date of Patent: September 10, 2024
    Assignee: Inhibrx Biosciences, Inc.
    Inventors: Kyle S. Jones, William Crago, Angelica Sanabria, Andrew Hollands, Jacob Gano, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • OX40-binding polypeptides and uses thereof
    Patent number: 12012459
    Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: June 18, 2024
    Assignee: Inhibrx, Inc.
    Inventors: John C. Timmer, William Crago, Kyle Jones, Katelyn Willis, Florian Sulzmaier, Bryan Becklund, Brendan P. Eckelman
  • CD123-binding polypeptides and uses thereof
    Patent number: 11919963
    Abstract: Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.
    Type: Grant
    Filed: August 1, 2022
    Date of Patent: March 5, 2024
    Assignee: Inhibrx, Inc.
    Inventors: Chelsie Macedo, Kyle Jones, William Crago, Andrew Hollands, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • CD33-Binding Polypeptides and Uses Thereof
    Publication number: 20230312716
    Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: December 16, 2022
    Publication date: October 5, 2023
    Applicant: Inhibrx, Inc.
    Inventors: Kyle S. Jones, William Crago, Angelica Sanabria, Andrew Hollands, Jacob Gano, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • OX40-Binding Polypeptides and Uses Thereof
    Publication number: 20230128188
    Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: August 8, 2022
    Publication date: April 27, 2023
    Applicant: Inhibrx, Inc.
    Inventors: John C. Timmer, William Crago, Kyle Jones, Katelyn Willis, Florian Sulzmaier, Bryan Becklund, Brendan P. Eckelman
  • CD123-Binding Polypeptides and Uses Thereof
    Publication number: 20230065306
    Abstract: Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: August 1, 2022
    Publication date: March 2, 2023
    Applicant: Inhibrx, Inc.
    Inventors: Chelsie Macedo, Kyle Jones, William Crago, Andrew Hollands, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • CD33-binding polypeptides and uses thereof
    Patent number: 11560428
    Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: January 24, 2023
    Assignee: Inhibrx, Inc.
    Inventors: Kyle S. Jones, William Crago, Angelica Sanabria, Andrew Hollands, Jacob Gano, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • CD33 TARGETED IMMUNOTHERAPIES
    Publication number: 20220324942
    Abstract: The present disclosure provides improved CD33 targeting polypeptides and compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
    Type: Application
    Filed: May 7, 2020
    Publication date: October 13, 2022
    Applicants: 2SEVENTY BIO, INC., INHIBRX, INC.
    Inventors: JORDAN JARJOUR, MARK POGSON, WAI-HANG LEUNG, KYLE JONES, WILLIAM CRAGO, ANGELICA SANABRIA, ANDREW HOLLANDS, JACOB GANO, MILTON MA, JOHN C. TIMMER, BRENDAN P. ECKELMAN
  • CD123 TARGETED IMMUNOTHERAPIES
    Publication number: 20220315638
    Abstract: The present disclosure provides improved CD123 targeting polypeptides and compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
    Type: Application
    Filed: May 7, 2020
    Publication date: October 6, 2022
    Applicants: 2SEVENTY BIO, INC., INHIBRX, INC.
    Inventors: JORDAN JARJOUR, MARK POGSON, WAI-HANG LEUNG, CHELSIE MACEDO, KYLE JONES, WILLIAM CRAGO, ANDREW HOLLANDS, MILTON MA, JOHN C. TIMMER, BRENDAN P. ECKELMAN
  • OX40-binding polypeptides and uses thereof
    Patent number: 11447556
    Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: September 20, 2022
    Assignee: Inhibex, Inc.
    Inventors: John C. Timmer, William Crago, Kyle Jones, Katelyn Willis, Florian Sulzmaier, Bryan Becklund, Brendan P. Eckelman
  • CD123-binding polypeptides and uses thereof
    Patent number: 11434297
    Abstract: Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: September 6, 2022
    Assignee: Inhibrx, Inc.
    Inventors: Chelsie Macedo, Kyle Jones, William Crago, Andrew Hollands, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • CD33-Binding Polypeptides and Uses Thereof
    Publication number: 20200347133
    Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 5, 2020
    Applicant: Inhibrx, Inc.
    Inventors: Kyle S. Jones, William Crago, Angelica Sanabria, Andrew Hollands, Jacob Gano, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • CD123-Binding Polypeptides and Uses Thereof
    Publication number: 20200347142
    Abstract: Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 5, 2020
    Applicant: Inhibrx, Inc.
    Inventors: Chelsie Macedo, Kyle Jones, William Crago, Andrew Hollands, Milton Ma, John C. Timmer, Brendan P. Eckelman
  • OX40-BINDING POLYPEPTIDES AND USES THEREOF
    Publication number: 20200055946
    Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: August 12, 2019
    Publication date: February 20, 2020
    Applicant: Inhibrx, Inc.
    Inventors: John C. Timmer, William Crago, Kyle Jones, Katelyn Willis, Florian Sulzmaier, Bryan Becklund, Brendan P. Eckelman