Abstract: Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.

Abstract: The present disclosure relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. Accordingly, in certain non-limiting embodiments, the present disclosure provides for methods, compositions and kits for a companion diagnostic for CDK4 inhibitors, and in particular, for the use of the colocalization of Enigma and CDH18 biomarkers to foci within the cancer for determining whether the cancer can be successfully treated by CDK4 inhibition.

Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.

Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.

Abstract: Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.

Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.

Abstract: The present disclosure provides improved CD33 targeting polypeptides and compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.

Abstract: The present disclosure provides improved CD123 targeting polypeptides and compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.

Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.

Abstract: Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.

Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.

Abstract: Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.

Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.

Abstract: A method of populating a location information database for use in providing a location-based service to a host device that is an endpoint of a logical connection between the host device and a network access server. The method comprises receiving from the host device over the logical connection a request for network access; assigning a logical identifier to the host device in response to the receiving; determining a physical location associated with the endpoint of the logical connection; creating an association between the logical identifier and the physical location; and storing the association in the location information database.

Abstract: A network element for use in a network that provides voice-over-packet services to a plurality of communication devices, each of the communication devices being associated with a respective directory number. The network element comprises an interface connectable to a trunk group dedicated to emergency calls and a control entity. The control entity is operable to: receive an incoming call originated by one of the communication devices; determine the directory number associated with the communication device having originated the incoming call; and determine whether the incoming call is an emergency call. Responsive to the incoming call being an emergency call, the control entity obtains a routing key that had been stored in association with the directory number; and directs the incoming call and the obtained routing key via the interface towards a gateway, the gateway connecting the network element to a dedicated emergency network.

Abstract: A method for execution by an owner of a mailbox in a voice mail system. The method comprises using an access device to access a voicemail message contained in the mailbox and entering a command instrumental in causing the voicemail message to be forwarded over a telephone network to a conversion entity. At the conversion entity, an electronic representation of the voicemail message is created and then the electronic representation of the voicemail message is rendered accessible to the owner of the mailbox, e.g., by sending an email message to a predetermined address. In this way, electronic representations of voicemail messages in a mailbox can be accessed by the owner of the mailbox using a device of choice, not necessarily the access device used initially to enter the command. Also, this functionality is achieved while allowing the voice mail system to remain a legacy voice mail system.

Abstract: A method of routing an emergency call received at a network element. The method comprises determining a directory number associated with a communication device having originated the emergency call, consulting a local database to obtain routing information associated with the directory number, and directing the call and the routing information over a path dedicated to emergency calls. Also, a network element which comprises the database as well as a control entity, the control entity being operative for receiving an incoming call originated by one of the communication devices, determining the directory number associated with the communication device having originated the call, determining whether the call is an emergency call and, responsive to the call being an emergency call, accessing the database to obtain the routing information related to the directory number and directing the call as well as the routing information over a trunk group dedicated to emergency calls.

Abstract: The delivery of emergency services to users of a set of communication devices in a packet-switched network is enabled by a method that determines a routing key corresponding to a particular directory number that is associated with a particular communication device, and stores the directory number and the corresponding routing key in a database accessible to a packet switch. The steps of determining and storing are executed during a provisioning phase, in the absence of an emergency call placed by the communication device. The routing key is indicative of routing instructions to be followed by the packet switch upon receipt of a future emergency call placed by the communication device. When the call is received by the packet switch, it will consult the database to obtain the routing key associated with the directory number and send the call as well as the routing key over a path dedicated to emergency calls.

Abstract: A method and system for controlling distribution of content through a communications network uses a second, parallel network for delivery of a transaction indicia to a requesting party. The use of the parallel network enables the transaction indicia to be forwarded to the party independently of the communications network, thereby reducing the probability of a party fraudulently obtaining delivery of the content. Additionally, information associated with the parallel network can be used to restrict distribution of the content to parties within a predetermined domain, such as, for example, a geographical region. The content may be delivered to the party in an encrypted form, preferably using an encryption algorithm and key designed to enable decryption of the content on only the content delivery device from which the request for the content was originated.