Abstract: The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.

Abstract: The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.

Abstract: The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.

Abstract: The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.

Abstract: A fistulary catheter for creating a sutureless mucosa-to-mucosa anastomosis. The catheter includes a rigid guide portion having a penetrating point and a fenestrated portion which has at least one fenestration communicating with a hollow interior and terminating in an opening which has an everted rim. The everted rim is desirably provided with a corrugated margin to grip the mucosa without compromising the blood supply. The guide portion may be hook shaped to guide the direction of the catheter or a metal probe may be used to guide a straight catheter. The guide portion may be flattened to minimize leakage around the guide portion. The fenestrated portion of the catheter may be straight or may be provided with varying degrees of tapering. The taper acts to hold the mucosa in place during the formation of the anastomosis. In an alternative embodiment, the fenestrated portion is straight without any taper and is used with spacers with differing diameters.

Abstract: An apparatus and method for using ultrasound augmented with microbubbles, thrombolytic drugs or other agents for clot lysis wherein at least one ultrasound transducer generates a plurality of acoustic signals and time, amplitude, phase and frequency modulation of the signals provide more uniform power delivery with fewer gaps in the ultrasound field. Interference patterns from one or multiple transducers are constantly shifted in position. A phased array of transducers may generate a beam that is swept over the area to be treated. In another embodiment, an array of transducers may generate ultrasound at a number of slightly varying frequencies to produce an interference pattern that sweeps in and out through the targeted tissue. A single array may be used to produce both effects simultaneously or separately.