Abstract: Provided herein are methods of treating prostate cancer having at least one pathogenic AR mutation using 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3- yl)methyl)benzo[d][1,3]dioxole-5-carboxamide, or a pharmaceutically acceptable salt thereof, alone or in combination with a therapeutically effective amount of an androgen receptor signaling inhibitor (ARSI) such as enzalutamide.

Abstract: Provided herein are methods for treating advanced relapsed solid tumors using 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2, 4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide; or a pharmaceutically acceptable salt thereof. Also provided herein are methods of treating cancers (e.g., solid tumors) using 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide; or a pharmaceutically acceptable salt thereof; and a second agent selected from a topoisomerase inhibitor, a DNA alkylating agent, and an androgen receptor signaling inhibitor.

Abstract: Provided herein are methods of treating subjects characterized as having a gene signature that is indicative of EZH2-inhibitor response, methods for determining said gene signature, and methods of determining which subjects may be responsive to cancer treatments based on said gene signature.

Abstract: Provided herein are methods of treating cancer using an effective amount of an EZH2 inhibitor and an effective amount of a second agent. Also provided are compositions comprising an EZH2 inhibitor and an effective amount of a second agent.

Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.

Abstract: Provided herein are pharmaceutical compositions comprising an EZH2 inhibitor and a type I interferon, processes for preparing such pharmaceutical compositions, and uses thereof in modulating the activity of histone methyl modifying enzymes.

Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.

Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.

Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.

Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.

Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.

Abstract: The amount of limonene and other pyrolytic oils within the condensate gases produced during pyrolysis of scrap tire carcasses or polyisoprene rubbers can be increased by fractionally condensing and liquefying the gaseous products in a series of vertical condensers. As the gases are passed through each successive condenser, fractions of the gases having a boiling point between 930 degrees Fahrenheit and 110 degrees Fahrenheit are separated and recovered.

Abstract: Apparatus, and a method for using the apparatus, for stripping solid material containing at least one volatile organic compound (VOC). The apparatus is provided with a dryer having a heat source to heat the VOC-containing material to a first temperature, hot enough to volatilize the VOC, but below the cracking temperature of the VOC. The VOC in the dryer is volatilized to form VOC gases. A means for combusting the VOC gases (e.g. a kiln) heats the VOC gases with excess air to a second temperature, hot enough to destroy the organics in the VOC gases. Simultaneously the combustion means preferably can be used to treat a kiln processable material to form a desired product. The kiln includes means for feeding the kiln processable material to the heating chamber, means for cooling and recovering the desired product, and means for providing heat for the VOC dryer. The apparatus also includes a conduit for conducting the gases containing VOC from the dryer to the kiln.

Abstract: A breakstem blind rivet comprises a deformable tubular shell 11 of aluminium alloy having a bore 12 inside it. A stem 13 of low-carbon steel is a close fit within the bore, extending along the bore and having a head 14 adjacent the tail end 15 of the shell. The outside of the shell is formed with at least three zones 27, 28, 29 of modified strength spaced apart along its length, these zones being in the form of shallow grooves rolled into the surface. The spacing between each zone 27, 28, 29 and the next progressively decreases as the distance along the shell from the tail end 15 increases. Alternatively the grooves may be formed by a turning process.

Abstract: A blind rivet able to be anchored in material such as softwood, without the need to break through the blind face of the material, comprises a tubular shell and a stem which extends through the shell. The shell has a preformed heat at one end of a shank. An end portion of the shank remote from the head has a thinner wall than the main, next adjacent, portion of the shank, and is thus weakened and made more easily expandible. The stem has a plugging portion having an expander head adjacent the thin-walled end portion of the shell, a breakneck, and a pulling portion which projects from the head end of the shell. The expander head increases in diameter away from the pulling portion, and presents a plurality of longitudinal cutting elements generally towards the weakened end portion of the shell. On gripping the pulling portion and pulling the stem, the cutting elements split the end portion of the shell into a plurality of legs, while the expander head enters into the end portion and forces the legs outwardly.

Abstract: A blind rivet, for anchoring in relatively soft material such as softwood, comprises a tubular shell (14) with a weakened portion (19) at the end remote from the head (18), and a stem (15) with an enlarged head (29) having a smooth underhead curve (32). The weakened portion (19) of the shell has four longitudinal V-section grooves (24) on its inner wall. In addition, the weakened portion (19) has a wall thickness which is less than that of the remainder (22) of the shell, the junction between the two parts presenting an internal annular shoulder (23). When tension is applied to the pulling portion (26) of the stem, the stem head (29) enters the weakened portion (19) and splits it apart along the grooves (24) to form legs which anchor in the soft material. The higher strength of the remainder part (22) of the shell prevents the stem head passing beyond the shoulder (23) before the stem fractures at the breakneck (27).

Abstract: Apparatus, and a method for using the apparatus, for detoxifying material contaminated with at least one volatile organic compound (VOC). The apparatus is provided with a dryer having a heat source to heat the VOC-contaminated material to a first temperature, hot enough to volatilize the VOC, but below the cracking temperature of the VOC. The VOC in the dryer is volatilized to form VOC gases. A kiln heats the VOC gases with excess air to a second temperature, hot enough to destroy the organics in the VOC gases. Simultaneously the kiln is used to treat a kiln processable material to form a desired product. The kiln includes means for feeding the kiln processable material to the heating chamber, means for cooling and recovering the desired product, and means for providing heat for the VOC dryer. The apparatus also includes a conduit for conducting the gases containing VOC from the dryer to the kiln.

Abstract: A threaded fastener for installation in threaded engagement with an initially unthreaded apertured workpiece and which after installation can be removed in the manner of a screw or bolt, has a shank and an enlarged head. At least part of the shank intermediate between its ends has an external screw thread having a sharp crest, and can be radially expanded to cause the thread to embed in the workpiece. A bore extends through the head and the entire shank or at least the threaded port of the shank for receiving means for expanding the shank. An end portion of the shank remote from the head may be unthreaded to avoid splitting of the shank during expansion.The method of installing the fastener involves pulling a tapered mandrel along the bore to expand the shank. The mandrel may have a key-forming head of non-circular cross-section whereby the bore of the fastener can be adopted to receive a key of non-circular cross-section for turning the fastener in the workpiece.

Abstract: A threaded fastener for installation in threaded engagement with an initially unthreaded apertured workpiece and which after installation can be removed in the manner of a screw or bolt, has a shank and an enlarged head. At least part of the shank intermediate between its ends has an external screw thread having a sharp crest, and can be radially expanded to cause the thread to embed in the workpiece. A bore extends through the head and the entire shank or at least the threaded part of the shank for receiving means for expanding the shank. An end portion of the shank remote from the head may be unthreaded to avoid splitting of the shank during expansion.The method of installing the fastener involves pulling a tapered mandrel along the bore to expand the shank. The mandrel may have a key-forming head of non-circular cross-section whereby the bore of the fastener can be adopted to receive a key of non-circular cross-section for turning the fastener in the workpiece.