Patents by Inventor William D. Bradley

William D. Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220257577
    Abstract: Provided herein are methods for treating advanced relapsed solid tumors using 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2, 4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide; or a pharmaceutically acceptable salt thereof. Also provided herein are methods of treating cancers (e.g., solid tumors) using 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide; or a pharmaceutically acceptable salt thereof; and a second agent selected from a topoisomerase inhibitor, a DNA alkylating agent, and an androgen receptor signaling inhibitor.
    Type: Application
    Filed: July 23, 2020
    Publication date: August 18, 2022
    Inventor: William D. Bradley
  • Publication number: 20210161883
    Abstract: Provided herein are methods of treating subjects characterized as having a gene signature that is indicative of EZH2-inhibitor response, methods for determining said gene signature, and methods of determining which subjects may be responsive to cancer treatments based on said gene signature.
    Type: Application
    Filed: July 10, 2018
    Publication date: June 3, 2021
    Inventors: William D. Bradley, Barbara M. Bryant, Patrick Trojer
  • Publication number: 20200093815
    Abstract: Provided herein are methods of treating cancer using an effective amount of an EZH2 inhibitor and an effective amount of a second agent. Also provided are compositions comprising an EZH2 inhibitor and an effective amount of a second agent.
    Type: Application
    Filed: July 27, 2016
    Publication date: March 26, 2020
    Inventors: Shilpi Arora, Srividya Balasubramanian, William D Bradley, Patrick Trojer
  • Patent number: 10314620
    Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: June 11, 2019
    Assignee: LDR Medical
    Inventors: Paul Cho, Reginald Davis, Gregory Hoffman, Alan McGee, John Williams, Arnold M. Schwartz, William D. Bradley, Alexandre Jodaitis, Herve Chataigner, Hugo Santos Benitez, Chen Zhongqiang
  • Publication number: 20180214519
    Abstract: Provided herein are pharmaceutical compositions comprising an EZH2 inhibitor and a type I interferon, processes for preparing such pharmaceutical compositions, and uses thereof in modulating the activity of histone methyl modifying enzymes.
    Type: Application
    Filed: July 24, 2015
    Publication date: August 2, 2018
    Inventors: Shilpi Arora, Srividya Balasubramanian, William D. Bradley, Patrick Trojer
  • Publication number: 20180036038
    Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.
    Type: Application
    Filed: August 15, 2017
    Publication date: February 8, 2018
    Inventors: Paul Cho, Reginald Davis, Gregory Hoffman, Alan McGee, John Williams, Arnold M. Schwartz, William D. Bradley, Alexandre Jodaitis, Herve Chataigner, Hugo Santos Benitez, Chen Zhongqiang
  • Patent number: 9730733
    Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: August 15, 2017
    Assignee: LDR Medical
    Inventors: Paul Cho, Reginald Davis, Gregory Hoffman, Alan McGee, John Williams, Arnold M. Schwartz, William D. Bradley, Alexandre Jodaitis, Herve Chataigner, Hugo Santos Benitez, Chen Zhongqiang
  • Publication number: 20150182259
    Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.
    Type: Application
    Filed: March 10, 2015
    Publication date: July 2, 2015
    Inventors: Paul Cho, Reginald Davis, Gregory Hoffman, Alan McGee, John Williams, Arnold M. Schwartz, William D. Bradley, Alexandre Jodaitis, Herve Chataigner, Hugo Santos Benitez, Chen Zhongqiang
  • Patent number: 8974497
    Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: March 10, 2015
    Assignee: LDR Medical
    Inventors: Paul Cho, Reginald Davis, Gregory Hoffman, Alan McGee, John Williams, Arnold M. Schwartz, William D. Bradley, Alexandre Jodaitis, Herve Chataigner, Hugo Santos Benitez, Chen Zhongqiang
  • Publication number: 20080255617
    Abstract: A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.
    Type: Application
    Filed: December 17, 2007
    Publication date: October 16, 2008
    Inventors: Paul Cho, Reginald Davis, Gregory Hoffman, Alan McGee, John Williams, Arnold M. Schwartz, William D. Bradley, Alexandre Jodaitis, Herve Chataigner, Hugo Santos Benitez, Chen Zhongqiang
  • Publication number: 20030114722
    Abstract: The amount of limonene and other pyrolytic oils within the condensate gases produced during pyrolysis of scrap tire carcasses or polyisoprene rubbers can be increased by fractionally condensing and liquefying the gaseous products in a series of vertical condensers. As the gases are passed through each successive condenser, fractions of the gases having a boiling point between 930 degrees Fahrenheit and 110 degrees Fahrenheit are separated and recovered.
    Type: Application
    Filed: December 18, 2001
    Publication date: June 19, 2003
    Inventor: William D. Bradley
  • Patent number: 5220874
    Abstract: Apparatus, and a method for using the apparatus, for stripping solid material containing at least one volatile organic compound (VOC). The apparatus is provided with a dryer having a heat source to heat the VOC-containing material to a first temperature, hot enough to volatilize the VOC, but below the cracking temperature of the VOC. The VOC in the dryer is volatilized to form VOC gases. A means for combusting the VOC gases (e.g. a kiln) heats the VOC gases with excess air to a second temperature, hot enough to destroy the organics in the VOC gases. Simultaneously the combustion means preferably can be used to treat a kiln processable material to form a desired product. The kiln includes means for feeding the kiln processable material to the heating chamber, means for cooling and recovering the desired product, and means for providing heat for the VOC dryer. The apparatus also includes a conduit for conducting the gases containing VOC from the dryer to the kiln.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: June 22, 1993
    Assignee: Keating Environmental Service, Inc.
    Inventors: Paul J. Keating, III, Alvah V. Barron, J. D. Derman, William D. Bradley
  • Patent number: 4958971
    Abstract: A breakstem blind rivet comprises a deformable tubular shell 11 of aluminium alloy having a bore 12 inside it. A stem 13 of low-carbon steel is a close fit within the bore, extending along the bore and having a head 14 adjacent the tail end 15 of the shell. The outside of the shell is formed with at least three zones 27, 28, 29 of modified strength spaced apart along its length, these zones being in the form of shallow grooves rolled into the surface. The spacing between each zone 27, 28, 29 and the next progressively decreases as the distance along the shell from the tail end 15 increases. Alternatively the grooves may be formed by a turning process.
    Type: Grant
    Filed: September 14, 1989
    Date of Patent: September 25, 1990
    Assignee: Avdel Limited
    Inventors: Raymond D. Lacey, William D. Bradley
  • Patent number: 4909687
    Abstract: A blind rivet able to be anchored in material such as softwood, without the need to break through the blind face of the material, comprises a tubular shell and a stem which extends through the shell. The shell has a preformed heat at one end of a shank. An end portion of the shank remote from the head has a thinner wall than the main, next adjacent, portion of the shank, and is thus weakened and made more easily expandible. The stem has a plugging portion having an expander head adjacent the thin-walled end portion of the shell, a breakneck, and a pulling portion which projects from the head end of the shell. The expander head increases in diameter away from the pulling portion, and presents a plurality of longitudinal cutting elements generally towards the weakened end portion of the shell. On gripping the pulling portion and pulling the stem, the cutting elements split the end portion of the shell into a plurality of legs, while the expander head enters into the end portion and forces the legs outwardly.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: March 20, 1990
    Assignee: Avdel Systems Limited, a British Company
    Inventors: William D. Bradley, Michael Woodrow, Raymond D. Lacey
  • Patent number: 4897003
    Abstract: A blind rivet, for anchoring in relatively soft material such as softwood, comprises a tubular shell (14) with a weakened portion (19) at the end remote from the head (18), and a stem (15) with an enlarged head (29) having a smooth underhead curve (32). The weakened portion (19) of the shell has four longitudinal V-section grooves (24) on its inner wall. In addition, the weakened portion (19) has a wall thickness which is less than that of the remainder (22) of the shell, the junction between the two parts presenting an internal annular shoulder (23). When tension is applied to the pulling portion (26) of the stem, the stem head (29) enters the weakened portion (19) and splits it apart along the grooves (24) to form legs which anchor in the soft material. The higher strength of the remainder part (22) of the shell prevents the stem head passing beyond the shoulder (23) before the stem fractures at the breakneck (27).
    Type: Grant
    Filed: February 10, 1989
    Date of Patent: January 30, 1990
    Assignee: Avdel Systems Limited
    Inventors: William D. Bradley, Michael Woodrow
  • Patent number: 4815398
    Abstract: Apparatus, and a method for using the apparatus, for detoxifying material contaminated with at least one volatile organic compound (VOC). The apparatus is provided with a dryer having a heat source to heat the VOC-contaminated material to a first temperature, hot enough to volatilize the VOC, but below the cracking temperature of the VOC. The VOC in the dryer is volatilized to form VOC gases. A kiln heats the VOC gases with excess air to a second temperature, hot enough to destroy the organics in the VOC gases. Simultaneously the kiln is used to treat a kiln processable material to form a desired product. The kiln includes means for feeding the kiln processable material to the heating chamber, means for cooling and recovering the desired product, and means for providing heat for the VOC dryer. The apparatus also includes a conduit for conducting the gases containing VOC from the dryer to the kiln.
    Type: Grant
    Filed: March 22, 1988
    Date of Patent: March 28, 1989
    Assignee: Keating Environmental Service, Inc.
    Inventors: Paul J. Keating, II, Alvah V. Barron, Jay D. Derman, William D. Bradley
  • Patent number: 4701993
    Abstract: A threaded fastener for installation in threaded engagement with an initially unthreaded apertured workpiece and which after installation can be removed in the manner of a screw or bolt, has a shank and an enlarged head. At least part of the shank intermediate between its ends has an external screw thread having a sharp crest, and can be radially expanded to cause the thread to embed in the workpiece. A bore extends through the head and the entire shank or at least the threaded port of the shank for receiving means for expanding the shank. An end portion of the shank remote from the head may be unthreaded to avoid splitting of the shank during expansion.The method of installing the fastener involves pulling a tapered mandrel along the bore to expand the shank. The mandrel may have a key-forming head of non-circular cross-section whereby the bore of the fastener can be adopted to receive a key of non-circular cross-section for turning the fastener in the workpiece.
    Type: Grant
    Filed: October 28, 1986
    Date of Patent: October 27, 1987
    Assignee: Advel Limited
    Inventors: William D. Bradley, Zia R. Alvi, Raymond D. Lacey
  • Patent number: 4642010
    Abstract: A threaded fastener for installation in threaded engagement with an initially unthreaded apertured workpiece and which after installation can be removed in the manner of a screw or bolt, has a shank and an enlarged head. At least part of the shank intermediate between its ends has an external screw thread having a sharp crest, and can be radially expanded to cause the thread to embed in the workpiece. A bore extends through the head and the entire shank or at least the threaded part of the shank for receiving means for expanding the shank. An end portion of the shank remote from the head may be unthreaded to avoid splitting of the shank during expansion.The method of installing the fastener involves pulling a tapered mandrel along the bore to expand the shank. The mandrel may have a key-forming head of non-circular cross-section whereby the bore of the fastener can be adopted to receive a key of non-circular cross-section for turning the fastener in the workpiece.
    Type: Grant
    Filed: May 24, 1984
    Date of Patent: February 10, 1987
    Assignee: Avdel Limited
    Inventors: William D. Bradley, Zia R. Alvi, Raymond D. Lacey