Patents by Inventor William D. Bugbee

William D. Bugbee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11369107
    Abstract: A live tissue storage solution is formed of an aqueous culture medium including additives, inorganic salts and nutrients. The additives preferably include amino acids including but not limited to L-Arg, L-Cys, Gly, L-His, L-Ile, L-Lys, L-Leu, L-Met, L-Phe, L-Ser, L-Try, L-Try, and L-Val. The inorganic salts preferably include calcium chloride, sodium chloride, magnesium sulphate, sodium bicarbonate, sodium phosphate. The nutrients preferably include glucose, choline, folic acid, nicinamide, riboflavin, which are known to maintain cell culture. Examples include Dulbecco's Modified Eagle Medium DMEM or Minimal Essential Medium MEM with or without serum. The culture medium contains additives to reduce, inhibit, or mitigate lipid oxidation, lipotoxicy, lipid-induced responses, and lipid inflammation.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: June 28, 2022
    Assignee: Restoration Biologies LLC
    Inventors: Suzanne M. Tabbaa, William D. Bugbee, Jonathan M. Page, Farshid Guilak
  • Publication number: 20200352154
    Abstract: A live tissue storage solution is formed of an aqueous culture medium including additives, inorganic salts and nutrients. The additives preferably include amino acids including but not limited to L-Arg, L-Cys, Gly, L-His, L-Ile, L-Lys, L-Leu, L-Met, L-Phe, L-Ser, L-Try, L-Try, and L-Val. The inorganic salts preferably include calcium chloride, sodium chloride, magnesium sulphate, sodium bicarbonate, sodium phosphate. The nutrients preferably include glucose, choline, folic acid, nicinamide, riboflavin, which are known to maintain cell culture. Examples include Dulbecco's Modified Eagle Medium DMEM or Minimal Essential Medium MEM with or without serum. The culture medium contains additives to reduce, inhibit, or mitigate lipid oxidation, lipotoxicy, lipid-induced responses, and lipid inflammation.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Inventors: Suzanne M. Tabbaa, William D. Bugbee, Jonathan M. Page, Farshid Guilak
  • Publication number: 20170258962
    Abstract: The present disclosure provides modified bone and osteochondral tissues, methods of preparing modified bone and osteochondral tissues, and methods of using the modified bone or osteochondral tissues to repair bone or osteochondral defects in a subject.
    Type: Application
    Filed: March 8, 2017
    Publication date: September 14, 2017
    Applicants: Colorado State University Research Foundation, The Regents of the University of California
    Inventors: Suzanne M. Tabbaa, David D. Frisbie, C. Wayne McIlwraith, Robert L. Sah, William D. Bugbee