Patents by Inventor WILLIAM D. CLAYPOOL

WILLIAM D. CLAYPOOL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A MEDICAMENT FOR TREATING MYCOBACTERIAL INFECTION CHARACTERIZED BY COMBINING A CYTOCHROME bc1 INHIBITOR WITH CLARITHROMYCIN OR AZITHROMYCIN AND CLOFAZIMINE
    Publication number: 20220235047
    Abstract: The present invention relates to novel combinations. The invention also relates to such combinations for use as pharmaceuticals, for instance in the treatment of bacterial diseases, including diseased caused by pathogenic mycobacteria such as non-tuberculosis mycobacteria. In particular, the present invention relates to a medicament, characterized in that a compound having a cytochrome bc1 inhibitory activity, or its pharmaceutically acceptable salt, is combined with clarithromycin or azithromycin, and clofazimine, or their pharmaceutically acceptable salts.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 28, 2022
    Applicants: Shionogi & Co., Ltd., HSIRI THERAPEUTICS, INC.
    Inventors: Kenzo NISHIGUCHI, Satoshi MIYAGAWA, William D. CLAYPOOL, Marvin J. MILLER, Garrett C. MORASKI, Jeffrey S. SCHOREY
  • COMPOSITIONS AND METHODS OF TREATING AND/OR PREVENTING LYSOSOMAL STORAGE DISEASES AND OTHER MONOGENETIC METABOLIC DISEASES
    Publication number: 20190224146
    Abstract: The present invention includes compositions for treating a lysosomal storage disease or disorder, and methods using same. In certain embodiments, the compositions of the invention comprise a histone deacetylase inhibitor (HDACi), a cyclodextrin, water, optionally a polyalkylene glycol, and optionally dimethyl sulfoxide (DMSO). In other embodiments, the compositions of the invention comprise a HDACi, a cyclodextrin, water, a polyalkylene glycol, and DMSO.
    Type: Application
    Filed: July 5, 2017
    Publication date: July 25, 2019
    Inventor: WILLIAM D. CLAYPOOL
  • COMPOSITIONS AND METHODS OF TREATING AND/OR PREVENTING CANCER
    Publication number: 20180353446
    Abstract: The present invention includes compositions for treating cancer, and methods using same. In certain embodiments, the compositions of the invention comprise a histone deacetylase inhibitor (HDACi), a cyclodextrin, water, optionally a polyalkylene glycol, and optionally dimethyl sulfoxide (DMSO). In other embodiments, the compositions of the invention comprise a HDACi, a cyclodextrin, water, a polyalkylene glycol, and DMSO.
    Type: Application
    Filed: June 7, 2018
    Publication date: December 13, 2018
    Inventor: WILLIAM D. CLAYPOOL