Abstract: Methods and monodisperse glass microsphere composites comprising a porous wall hollow-glass microsphere; a cargo of a therapeutic is loaded inside of the porous wall hollow-glass microsphere; and a first shell fully encapsulating the porous wall hollow-glass microsphere and capping pores in the walls, retaining the cargo inside of the porous wall hollow-glass microsphere.

Abstract: Compositions and methods for glass composites suitable for tissue augmentation, biomedical, and cosmetic applications are provided. The glass microsphere component of the composites are biologically inert, non-reactive and act as a nearly permanent tissue filler. One embodiment provides a tissue augmentation composite containing an effective amount of solid glass microspheres, hollow glass microspheres, porous wall hollow glass microspheres, or combinations thereof with a suitable biocompatible matrix to serve as a bulking agent when injected into a patient. The compositions can be used for soft or hard tissue augmentation as well as delivery of cargos on demand.

Abstract: Compositions and methods for glass composites suitable for tissue augmentation, biomedical, and cosmetic applications are provided. The glass microsphere component of the composites are biologically inert, non-reactive and act as a nearly permanent tissue filler. One embodiment provides a tissue augmentation composite containing an effective amount of solid glass microspheres, hollow glass microspheres, porous wall hollow glass microspheres, or combinations thereof with a suitable biocompatible matrix to serve as a bulking agent when injected into a patient. The compositions can be used for soft or hard tissue augmentation as well as delivery of cargos on demand.

Abstract: Compositions and methods for glass composites suitable for tissue augmentation, biomedical, and cosmetic applications are provided. The glass microsphere component of the composites are biologically inert, non-reactive and act as a nearly permanent tissue filler. One embodiment provides a tissue augmentation composite containing an effective amount of solid glass microspheres, hollow glass microspheres, porous wall hollow glass microspheres, or combinations thereof with a suitable biocompatible matrix to serve as a bulking agent when injected into a patient. The compositions can be used for soft or hard tissue augmentation as well as delivery of cargos on demand.

Abstract: Compositions and methods for modulating miRNAs up-regulated or down-regulated in aged individuals and their downstream targets are disclosed. Methods of treating musculoskeletal disorders are also provided.

Abstract: Compositions and methods of increasing autophagy in a cell, or population of cells are disclosed. The methods generally include contacting the cell or cells with an effective amount of an agent that increases the bioavailability of an active isoform of SDF-1. Exemplary agents include active SDF-1 polypeptides, metformin, and DPP4 inhibitors. The methods can include administering the agent to a subject, or treating cells in vivo, in vitro or ex vivo. In some embodiments, cells are treated ex vivo and then transplanted into a subject. In a preferred embodiment, the cells are mesenchymal stem cells such as those found in bone marrow. The compositions and methods can be utilized in a number of therapeutic applications including increasing the longevity or survival of a graft or transplant, increasing the rate of recovery from an injury, reducing one or more symptoms of a chronic inflammatory disease and reducing effect associated with aging.

Abstract: Compositions and methods for modulating miRNAs up-regulated or down-regulated in aged individuals and their downstream targets are disclosed. Methods of treating musculoskeletal disorders are also provided.

Abstract: An adjustable curtain rod assembly includes a rod member and an adjustment mechanism coupled to an end of the rod member. The adjustment mechanism is operable to adjust a length of the rod assembly and has a clutch mechanism that prevents over-extension of the rod assembly during mounting.

Abstract: An adjustable curtain rod assembly includes a rod member and an adjustment mechanism coupled to an end of the rod member. The adjustment mechanism is operable to adjust a length of the rod assembly and has a clutch mechanism that prevents over-extension of the rod assembly during mounting.

Abstract: An adjustable curtain rod assembly includes a rod member and an adjustment mechanism coupled to an end of the rod member. The adjustment mechanism is operable to adjust a length of the rod assembly and has a clutch mechanism that prevents over-extension of the rod assembly during mounting.

Abstract: A finial for a curtain rod includes a first finial base portion configured to surround a portion of a curtain rod and a second finial base portion configured to surround another portion of the curtain rod and to mate with the first finial base portion. An interface between the mating first and second finial base portions defines a parting line. A retaining member is engaged with the first finial base portion and movable between a first position, wherein the retaining member does not span the parting line and does not engage the second finial base portion, and a second position, wherein the retaining member spans the parting line and engages the second finial base portion.

Abstract: An adjustable curtain rod assembly includes a rod member and an adjustment mechanism coupled to an end of the rod member. The adjustment mechanism is operable to adjust a length of the rod assembly and has a clutch mechanism that prevents over-extension of the rod assembly during mounting.

Abstract: A card carrier is displayed for sale with at least two independently redeemable cards affixed thereto. A barcode is displayed on the package that is associated with an account number encoded on a magnetic stripe or barcode of each of the cards. Both cards are valued at a point of sale by a sales clerk scanning in the single bar code on the package. The cards can then be redeemed at a merchant associated with each of the cards.

Abstract: A portable, microprocessor-based test instrument for the calibration, check testing, and checkout of nuclear power reactor systems under simulated operating conditions. The instrument includes a master microprocessor bus having direct communication to interchangeable plug-in printed circuit boards. Applications to which the invention may be put include rod control simulation and analysis, neutron monitoring system analysis, and rod block monitoring system simulation and analysis. The test instrument electronically interconnects at any of a plurality of points within a reactor control and monitoring system. The electrical network from the point of interconnection to the core rods is disabled and the test instrument, receives serial control command signals as would the disabled portion of the network. The test instrument also generates appropriate acknowledgements and response signals. Alternatively, a test instrument can generate faulty response signals to simulate improper command responses.

Abstract: A femtoammeter is disclosed which resists noise induced reversed bias of the ammeter amplifier and avoids long time constant recovery with unusually high measurement accuracy. The amplifier ammeter has a feedback loop which is provided with paired opposingly faced log diodes in parallel across the feedback circuit. Transients of negative or positive bias are accommodated without biasing the amplifier to a reverse polarity and having unacceptably long time constant recovery. Conventional temperature compensation, not possible with the parallel reversed diode configuration, is supplied by heat sinking the ammeter components, providing a log diode temperature sensor for the heat sinked components and controlling the heat sink operating temperature with a thermoelectric cooler. The temperature sensing log diodes output to a computer lookup table. The same temperature sensing log diode outputs to a bridge circuit operating the thermoelectric cooler.

Abstract: The present invention described a signal conditioner. A thermocouple produces a signal that is present at a summing node input of a conditioning amplifier. The conditioning amplifier has a plurality of selectable gain values by which amplifier sensitivity may be varied to complement that of the thermocouple. Provision is made at the summing node input of the summing amplifier for thermocouple cold junction compensation and range offset. The present invention finds application in monitoring thermal conditions in an industrial process, such as a nuclear reactor. The high degree of precision and reliability required in such processes is maintained by including a test circuit which provides a selectable test pulse to the summing node input of the conditioning amplifier. One aspect of the present invention is the provision for testing during actual circuit operation in a process and irrespective of selected conditioning amplifier sensitivity.

Abstract: A redundant reactivity control system, operating in conjunction with other systems in a nuclear power plant, to mitigate the potential consequences of an anticipated transient without scram event, is described. The invention interfaces to a boiling water nuclear reactor with the reactor's neutron monitoring system, standby liquid control system, control rod drive system, reactor recirculation system, reactor water clean-up feed water control system, and control room and local panels. Two divisionally separated control panels include associated detection and actuation logic and the necessary interface logic to other systems to perform the specific functions in response to an anticipated transient without scram event. Each separate division includes two identical channels. Actuation of any associated reactor system by the invention requires the agreement of the two channels within a division.

Abstract: A universal logic card is disclosed which contains both pre-programmed functional circuitry for actuating channel logic and dedicated test circuitry for system controller test and for constant and looping interrogation of the pre-programmed channel logic in absence of self-test system controller test. The disclosed card resides as a channel in a self-test system for a nuclear power plant supplementing the nuclear reaction protection system. The card is pre-programmed in digital logic to act equivalent to an analog circuit during actual plant operation. Additionally, the card responds to system controlled surveillance of the nuclear protection system. In system controlled surveillance, a central microprocessor serially addresses system circuit cards such as the one disclosed and loads these cards at predetermined input points with test commands. The addressed cards are thereafter simultaneously activated by a system-wide command.

Abstract: A resistor temperature device (RTD) trip unit is described. The RTD monitors thermal conditions at an industrial process location, such as in a nuclear reactor. Resistance of the RTD varies in accordance with temperature at the monitored process location. An amplifier circuit produces an output signal, corresponding to the variations in RTD resistance, which signal operates a plurality of relay circuits. The relay circuits variously report process conditions such as failure, the obtaining of a preselected level, etc. Additionally, metering provides a continuous analog indication of thermal conditions at the monitored process locations. To correct for non-linearity inherent in the RTD resistance slope, a recursive feedback path is coupled between the RTD amplifier stage and an RTD current source, such that a decreasing resistance slope produces a complementary increase in current supply to the RTD. The result is a linear output signal from the RTD amplifier.

Abstract: A testable time delay apparatus includes means for testing component operation during any stage of system function and means for continuously monitoring and testing component functions. The device is particularly useful in critical process control applications such as in a nuclear reactor control system.